Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut microbiota in growing pigs

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Language: Английский

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Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: July 29, 2024

Abstract The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut secrete abundant extracellular vesicles (Gm‐EVs), which play a critical role bacteria‐to‐bacteria and bacteria‐to‐host communications. Herein, intestinal are trained using tea leaf lipid/pluronic F127‐coated curcumin nanocrystals (CN@Lp 127 s), can maintain stability during transit through the gastrointestinal tract. Compared FMT, Gm‐EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring barrier function, rebalancing microbiota. Strikingly, obtained CN@Lp ‐trained exhibit superior therapeutic effect on compared to groups receiving FMT mice, mice. Oral administration of not only alleviates inflammation, promotes mucosal repair, regulates gut but also purine metabolism decrease uric acid level, resulting robust improvement UC. This study demonstrates efficacy nanomedicine‐trained regulating immune microenvironment, microbiota, colon. These EVs provide an alternative platform replace as for

Language: Английский

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Effect of anthocyanins on the in vitro fermentation of high-amylose starch

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123271 - 123271

Published: Jan. 14, 2025

Language: Английский

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Multi-Omics Reveal the Effects and Regulatory Mechanism of Dietary Magnolol Supplementation on Production Performance of Post-Peak Laying Hens

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

This study aimed to investigate the therapeutic effects of magnolol on production performance in postpeak laying hens. We divided hens into three groups (ND, MAG300, MAG500) and conducted a 10-week feeding trial. The results indicated that daily supplementation with improved rate, reduced feed-to-egg ratio, controlled liver fat accumulation, alleviated ovarian oxidative stress apoptosis. Additionally, 16S rDNA analysis revealed increased microbial diversity cecum, augmented abundance beneficial bacteria, diminished harmful bacteria. Untargeted metabolomics blood demonstrated concentration glycerophospholipid-related metabolites while increasing levels propionate amino acid metabolites. Furthermore, transcriptome inhibited fatty synthesis, transport, elongation, promoting oxidation. These collectively demonstrate can positively regulate gut-liver-ovary axis enhance

Language: Английский

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Artemisia annua L. polysaccharide improves the growth performance and intestinal barrier function of broilers challenged with Escherichia coli

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 30, 2024

With the high intensification of poultry breeding, a series diseases caused by pathogenic bacteria threaten health and human. Among them, induced Escherichia coli cause significant economic loss every year. The aim this study was to investigate effects dietary supplementation with Artemisia annua L. polysaccharide (AAP) on growth performance intestinal barrier function broilers ( E. ) challenge. A total 256 one-day-old chicks were randomly assigned four treatment groups: control group (fed basal diet), AAP diet supplemented AAP), orally administered ), + ). Dietary elevated BW, ADG ADFI in non-challenged broilers. also increased apparent metabolic rate EE Ca -challenged Moreover, not only enhanced serum IgA content but decreased jejunum IL-6, as well level IL-1β down-regulates mRNA inflammatory factors , IL-6 TNF-α inhibiting expression TLR4 MyD88 NF-κB signaling pathway Meanwhile, up-regulates activity CAT down-regulating Keap1 Nrf2 broilers, MDA concentration. significantly SOD jejunal Interestingly, can improve physical ET content, increasing villus height/crypt depth (VH/CD) ZO-1 challenged . VH/CD Occludin Mucin-2 Importantly, reshaped balance microbiota altering α diversity community composition. In summary, ameliorated probably regulating permeability mucosa morphology, immune function, antioxidant ability, microbiota.

Language: Английский

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Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103825 - 103825

Published: May 11, 2024

This study was designed to examine the impact of aspirin eugenol ester (AEE) on growth performance, serum antioxidant capacity, jejunal barrier function, and cecal microbiota broilers raised under stressful high density (HD) stocking conditions compared with normal (ND). A total 432 one-day-old AA+ male were randomly divided into 4 groups: (ND, 14 /m

Language: Английский

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Effects of a dietary isoquinoline alkaloids blend on gut antioxidant capacity and gut barrier of young broilers

Poultry Science, Journal Year: 2024, Volume and Issue: 103(5), P. 103654 - 103654

Published: March 14, 2024

Extensive mechanistic evidence to support the beneficial function of dietary phytobiotic applications for broiler performance, gut and health is highly warranted. In particular, isoquinoline alkaloids (IQ) underlying mechanisms related critical homeostasis components such as cytoprotection barrier are scarce, especially young broilers at starter growth stage (d1-10). The aim this study was investigate effect a standardized blend IQs on relative gene expression biomarkers relevant antioxidant response along intestine end phase. For purpose, 182 one-day-old Ross 308 were allocated in 2 treatments with 7 replicates 13 each: control diet-no other additions (NC), diet containing 200 mg/kg (M) period (1-10d). results revealed that significantly upregulated (P < 0.05) genes all intestinal segments. Moreover, enhanced primarily duodenal level. conclusion, beneficially affected pathway capacity broilers.

Language: Английский

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Effect of dietary supplementation with sanguinarine on meat quality and lipid metabolism of broilers

Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103925 - 103925

Published: May 31, 2024

Dietary Macleaya cordata extract (MCE) can improve the meat quality of poultry. However, specific mechanism by which MCE regulates has not been clarified yet. Sanguinarine (SAN) is one important natural active components in MCE. Our study aims to explore regulatory dietary SAN supplementation on through transcriptomic and gut microbiome analysis, thereby providing a basis for regularing with 240 1-day-old broilers were divided into 4 groups according different doses (0, 0.225, 0.75 2.25 mg/kg). The results indicated that significantly physicochemical indicators breast thigh muscle broilers, improved serum biochemical indexes. Through transcriptome sequencing analysis liver ileum tissues we found differentially expressed genes induced mainly enriched lipid metabolism, related peroxisome proliferator-activated receptor (PPAR) pathway. It reconfirmed regulate metabolism body promoting expression cholesterol fatty acid transport oxidation RT-PCR, this ultimately affects muscle. Additionally, 16S rRNA addition increased relative abundance Bacteroides, Lactobacillus unclassified_f_Lachnospiraceae, while decreased Alistipes ceca. To further investigate impact microbiota conducted correlation PPAR pathway factor cecum tissue microflora structure. showed Bacteroides exhibited positive most signaling Unclassified_f__Lachnospiraceae positively correlated PPARγ, Cytochrome P450 family 7 subfamily A member 1 (CYP7A1) Acyl-CoA synthetase long-chain 5 (ACSL5). In conclusion, promote pathway, target regulation intestinal structure improving broilers.

Language: Английский

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Language: Английский

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The interaction between Angelica sinensis polysaccharide ASP-2pb and specific gut bacteria alleviates rheumatoid arthritis in rats

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140473 - 140473

Published: Jan. 1, 2025

Language: Английский

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