Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review DOI Creative Commons
Alessandra Di Salvo, Elisabetta Chiaradia, Monica Sforna

et al.

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(5), P. 2915 - 2941

Published: Aug. 20, 2024

Since the discovery of endocannabinoid system and due to empirical evidence therapeutic effects on several illnesses both in humans animals that follow administration exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed identify expression distribution cannabinoid receptors healthy pathologic organs tissues different animal species define interactions phytocannabinoids with these receptors. In last decade, pharmacokinetics, efficacy tolerability many Cannabis derivatives formulations, mainly containing cannabidiol, main veterinary interest, also investigated. This manuscript summarizes findings reported by scientific published so far molecular mode action phytocannabinoids, localization tissues, as well dogs, cats, horses other interest. A deep knowledge issues is crucial for use purposes species.

Language: Английский

Effect of cannabinoid consumption on propofol dosage: a systematic review and meta-analysis DOI
Helmar Bornemann‐Cimenti, Kordula Lang-Illievich, Stefan Neuwersch-Sommeregger

et al.

British Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry DOI Creative Commons

Panisara Suriyawongpongsa,

Sirirat Niyom,

Kannika Wanapinit

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1393 - 1393

Published: May 12, 2025

Cannabidiol (CBD), a non-psychotropic cannabinoid derived from Cannabis plants, is increasingly explored for its potential therapeutic applications in veterinary medicine. This study aimed to evaluate the impact of CBD oil on minimum alveolar concentration isoflurane (MACiso) cats. Sixteen healthy cats underwent anesthesia, and MACiso was determined using tail-clamping technique both at baseline 30 min after administration (2 mg/kg) via stomach tube. resulted significant 11% reduction MACiso, 1.77 ± 0.14% 1.62 0.21% (p < 0.001). Following administration, heart respiratory rates were elevated time determination compared whereas other physiological parameters remained unchanged. Serum biochemical analysis conducted two weeks post revealed decrease blood urea nitrogen (BUN) levels while one cat exhibited mild increase alanine aminotransferase (ALT). Proteomic identified 12 CBD-associated proteins feline serum with CBDA THCA synthases demonstrating upregulation. These findings indicate that reduces anesthetic requirements without inducing disturbances. Further research warranted elucidate underlying mechanisms CBD’s anesthetic-sparing effects implications anesthesia.

Language: Английский

Citations

0
Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review DOI Creative Commons
Alessandra Di Salvo, Elisabetta Chiaradia, Monica Sforna

et al.

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(5), P. 2915 - 2941

Published: Aug. 20, 2024

Since the discovery of endocannabinoid system and due to empirical evidence therapeutic effects on several illnesses both in humans animals that follow administration exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed identify expression distribution cannabinoid receptors healthy pathologic organs tissues different animal species define interactions phytocannabinoids with these receptors. In last decade, pharmacokinetics, efficacy tolerability many Cannabis derivatives formulations, mainly containing cannabidiol, main veterinary interest, also investigated. This manuscript summarizes findings reported by scientific published so far molecular mode action phytocannabinoids, localization tissues, as well dogs, cats, horses other interest. A deep knowledge issues is crucial for use purposes species.

Language: Английский

Citations

2