Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
31(12), P. 101826 - 101826
Published: Oct. 16, 2023
Nipah
virus,
a
paramyxovirus
linked
to
Hendra
virus
that
first
appeared
in
Malaysia
and
is
the
etiological
agent
of
viral
lethal
encephalitis,
has
emerged
as
strong
threat
health
community
recent
decades.
Viral
infections
are
seriously
affecting
global
health.
Since
there
now
no
efficient
therapeutic
options,
it
will
take
considerable
effort
develop
appropriate
management
for
virus.
The
main
purpose
this
study
was
design
messenger
RNA-based
multi-epitope
vaccine
construct
against
This
achieved
through
multiple
immunogenic
epitopes
prediction
using
antigenic
protein
immune
epitope
database
analysis
resource
(IEDB)
followed
by
construction
processing.
As
multi-epitopes
we
selected
potential
fragments
proteins,
therefore
host
stimulation
observed
proper
responses
toward
vaccine.
In
study,
V
used
identify
immunodominant
utilizing
several
reverse
vaccinology,
immunoinformatics
biophysical
methods.
predicted
were
further
analyzed
only
probable
non-toxic
designing
mRNA
based
silico
target
pathogen.
total
number
03B
cell
epitopes,
09
Cytotoxic
T
lymphocytes
(CTLs)
01
Helper
(HTL)
prioritized
good
candidate.
phase,
together
EAAAK,
GPGPG,
KK,
AAY
linkers,
B-defensin
(adjuvant),
MITD
sequences
also
added
increase
potency.
After
construction,
physiochemical
properties
evaluated
which
comprises
320
amino
acids
with
34.29
kDa
(kDa)
molecular
weight.
instability
index
36.55
proving
its
stability
aliphatic
82.88.
Furthermore,
9.0
theoretical
pI
-0.317,
GRAVY
(Grand
Average
Hydropathy)
values
physicochemical
analysis.
A
solubility
check
applied
depicting
soluble
calculated
value
0.6.
Additionally,
after
3D
structure
modeled
refined
docking
analysis,
candidate
checked
binding
affinity
receptors
cells
receptor
can
induce
response
cells.
effective
designed
construct,
hence
facilitate
development
formulation
dynamic
simulation
done
AMBER
v20
package
behaviour
docked
complexes
receptor.
C-immune
simulation,
different
humoral
cellular
antibody
titer
Overall
bioinformatics,
immunoinformatics,
approaches
base
could
proof
concept
formation
experimental
predictions
indicated
highly
promising
terms
developing
protective
immunity.
However
validation
required
disclose
real
immune-protective
efficacy
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e19682 - e19682
Published: Sept. 1, 2023
Nipah
virus,
which
originated
in
South-East
Asia
is
a
bat-borne
virus
causing
infection
humans.
This
emerging
infectious
disease
has
become
one
of
the
most
alarming
threats
to
public
health
due
its
periodic
outbreaks
and
extremely
high
mortality
rate.
We
establish
study
novel
SIRS
model
describe
dynamics
transmission,
considering
human-to-human
as
well
zoonotic
transmission
from
bats
pigs
loss
immunity.
determine
basic
reproduction
number
can
be
obtained
maximum
three
threshold
parameters
corresponding
various
ways
determining
species
becomes
endemic.
By
constructing
appropriate
Lyapunov
functions,
we
completely
global
our
depending
on
these
parameters.
Numerical
simulations
are
shown
support
theoretical
results
assess
effect
intervention
measures.
Animals,
Journal Year:
2023,
Volume and Issue:
13(20), P. 3281 - 3281
Published: Oct. 20, 2023
The
available
data
indicate
that
the
human
world
population
will
constantly
grow
in
subsequent
decades.
This
constant
increase
number
of
people
on
Earth
lead
to
growth
food
demand,
especially
high
nutritional
value.
Therefore,
it
is
expected
livestock
also
increase.
Such
a
phenomenon
enhances
risk
transmitting
pathogens
humans.
As
pig
production
one
most
significant
branches
world's
production,
zoonoses
porcine
origins
seem
be
particular
importance.
this
review,
we
aim
introduce
latest
concerning,
among
other
things,
epidemiology
and
preventive
measures
control
viral,
bacterial,
parasitic
origin.
New Microbes and New Infections,
Journal Year:
2025,
Volume and Issue:
64, P. 101575 - 101575
Published: March 5, 2025
Nipah
virus
(NiV),
a
zoonotic
pathogen
with
global
implications,
poses
multifaceted
challenges.
Highlighting
the
virus's
diverse
strains
and
recurrent
outbreaks,
we
explore
rapid
course
of
infections,
diagnostic
limitations,
pressing
need
for
therapeutic
advancements.
Emphasizing
complex
dynamics
viral
transmission;
urgency
comprehensive
biosecurity
measures
early
detection
systems
is
highlighted.
This
advocates
robust
response
to
address
evolving
landscape
NiV,
emphasizing
collaborative
efforts
mitigate
its
impact
on
public
health.
Veterinary Sciences,
Journal Year:
2025,
Volume and Issue:
12(3), P. 288 - 288
Published: March 19, 2025
West
Nile
virus
(WNV)
is
an
important
zoonotic
pathogen
belonging
to
the
Flaviviridae
family,
which
endemic
in
some
areas
and
emerging
others.
WNV
transmitted
by
blood-sucking
mosquitoes
of
genus
Culicoides,
Aedes,
Anopheles,
infection
can
cause
different
clinical
symptoms.
The
most
common
benign
illness
humans
fever
(WNF),
but
a
lethal
neurological
disease
(WNND),
related
neuro-invasiveness
lineage
2,
represents
highest
health
risk
infection.
neuro-clinical
form
recognized
mammals
(land
cetaceans),
particularly
(elderly
or
immunosuppressed)
horses,
avian
species,
wildlife
animals
ranging
free
zoological
setting.
This
review
highlights
relevant
data
regarding
epidemiology,
virology,
pathogenesis
immunity,
signs
differential
diagnosis,
pathology
imaging,
histopathology
gross
pathology,
economic
impact,
influence
climate
change,
surveillance
WNV.
Climate
change
has
favored
wide
spread
many
globe
consequent
One-Health
Eco-Health
emergencies,
influencing
human
beings,
animals,
ecosystems.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 12, 2025
Deforestation,
urbanization,
and
climate
change
have
significantly
increased
the
risk
of
zoonotic
diseases.
Nipah
virus
(NiV)
Paramyxoviridae
family
Henipavirus
genus
is
transmitted
by
Pteropus
bats.
Climate-induced
changes
in
bat
migration
patterns
food
availability
enhances
virus's
adaptability,
turn
increasing
potential
for
transmission
outbreak
risk.
NiV
infection
has
high
human
fatality
rate.
With
no
antiviral
drugs
or
vaccines
available,
exploring
complex
machinery
involved
viral
RNA
synthesis
presents
a
promising
target
therapy.
Drug
repurposing
provides
fast-track
approach
identifying
existing
with
to
RNA-dependent
polymerase
(L),
bypassing
time-consuming
process
developing
novel
compounds.
To
facilitate
this,
we
developed
an
attention-based
deep
learning
model
that
utilizes
pharmacophore
properties
active
sites
their
binding
efficacy
L
protein.
Around
500
FDA-approved
were
filtered
assessed
ability
bind
Compared
control
Remdesivir,
identified
Cangrelor,
antiplatelet
drug
cardiovascular
diseases,
stronger
affinity
(glide
score
-12.30
kcal/mol).
Molecular
dynamics
simulations
further
revealed
stable
(RMSD
3.54
Å)
post-MD
energy
-181.84
kcal/mol.
The
strong
Cangrelor
illustrated
through
trajectory
analysis,
principal
component
solvent
accessible
surface
area,
confirming
interaction
site
RdRp.
can
interact
protein
may
potentially
interfere
its
replication.
These
findings
suggest
will
be
candidate
effectively
disrupt
Further
vivo
studies
are
warranted
explore
as
repurposable
drug.
