An In Vitro Evaluation of Industrial Hemp Extracts Against the Phytopathogenic Bacteria Erwinia carotovora, Pseudomonas syringae pv. tomato, and Pseudomonas syringae pv. tabaci DOI Creative Commons

Getrude G. Kanyairita,

D.G. Mortley,

Willard E. Collier

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5902 - 5902

Published: Dec. 13, 2024

Pests and diseases have caused significant problems since the domestication of crops, resulting in economic loss hunger. To overcome these problems, synthetic pesticides were developed to control pests; however, there are detrimental side effects on environment human health. There is an urgent need develop safer more sustainable pesticides. Industrial hemp a reservoir compounds that could potentially replace some bactericides, fungicides, insecticides. We determined efficacy industrial extracts against Pseudomonas syringae pv. tabaci (PSTA), tomato (PSTO), Erwinia carotovora (EC). The study revealed minimum inhibitory concentration (MIC) 2.05 mg/mL non-inhibitory (NIC) 1.2 for PSTA, MIC 5.7 NIC 0.66 PSTO, 12.04 5.4 EC. Time-kill assays indicated regrowth E. at 4 × after 15 h P. 2 20 h; had no regrowth. susceptibility test bacteria extract can be ordered from most susceptible least susceptible, as follows: > carotovora. Overall, data indicate potential source safe biopesticides major plant pathogens.

Language: Английский

Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications DOI Creative Commons
Oana Elena Nicolaescu, Cătălina Ionescu, Adriana Samide

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 506 - 506

Published: April 11, 2025

Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in pharmaceutical field, among which formation of inclusion complexes (ICs) natural or synthetic lipophilic compounds. This review prioritizes research recent years (2022–2025), being focused on (1) systematization ICs based structure secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes terpenoids (TTs), (iii) alkaloids (Alks); (2) each type complex, following aspects discussed: benefits complexation, composite materials, vitro/in vivo theoretical studies; (3) pharmacokinetics pharmacodynamics, risks, limitations, perspectives cyclodextrin metabolites.

Language: Английский

Citations

0
Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens DOI Creative Commons
Adriana Ribeiro,

Rahaf Alsayyed,

Daniele Martins de Lima Oliveira

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(3), P. 590 - 625

Published: Sept. 9, 2024

Cannabis sativa L. has garnered attention as a potential source for new antimicrobial agents, particularly due to the increased prevalence of microbial resistance conventional antimicrobials and emergence multidrug-resistant pathogens. This review, conducted according PRISMA 2020 statement, systematically analyzed properties C. extracts cannabinoids against various bacteria, fungi, viruses, parasites. Data were collected from scientific literature (102 papers) clinical trials (5 studies) 2014 June 2024. Findings revealed that cannabinoids, especially CBD, demonstrate significant activity Gram-positive bacteria like MRSA, Gram-negative such Pseudomonas aeruginosa, Candida species, SARS-CoV-2, HIV. Additionally, CBD showed efficacy parasitic infections Echinococcus granulosus Leishmania species. These results suggest may represent class agents with unique diverse mechanisms action, potentially effective in broad-spectrum therapies. study highlights urgent need further research standardized validate these findings develop cannabinoid-based treatments. The align WHO priorities support global health initiatives, offering promising avenues addressing improving public outcomes.

Language: Английский

Citations

3
Deciphering the Phytochemical Potential of Hemp Hairy Roots: A Promising Source of Cannabisins and Triterpenes as Bioactive Compounds DOI Creative Commons

Naomi Kaminsky,

Jane Hubert, Cédric Guerin

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5792 - 5792

Published: Dec. 7, 2024

Cannabis sativa L., specifically hemp, is a traditional herbaceous plant with industrial and medicinal uses. While much research has focused on cannabinoids terpenes, the potential of hemp roots less explored due to bioproduction challenges. Still, this material rich in bioactive compounds demonstrates promising anti-inflammatory, antimicrobial, antioxidant properties. Biotechnological methods, such as hairy root cultures, enable efficient production specialized metabolites while avoiding issues outdoors cultures. Despite these benefits, chemical diversity understanding remains limited. In study, we conducted an extensive NMR LC/MS profiling determine their composition, revealing presence cannabisins for first time. We then investigated accumulation triterpenes both aeroponic roots. Our findings reveal that produce 12 times more 6 than roots, respectively, addition yielding 3 biomass bioreactors. Preliminary bioassays also suggest antifungal This underscores valuable source calls further exploration into applications.

Language: Английский

Citations

1
An In Vitro Evaluation of Industrial Hemp Extracts Against the Phytopathogenic Bacteria Erwinia carotovora, Pseudomonas syringae pv. tomato, and Pseudomonas syringae pv. tabaci DOI Creative Commons

Getrude G. Kanyairita,

D.G. Mortley,

Willard E. Collier

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5902 - 5902

Published: Dec. 13, 2024

Pests and diseases have caused significant problems since the domestication of crops, resulting in economic loss hunger. To overcome these problems, synthetic pesticides were developed to control pests; however, there are detrimental side effects on environment human health. There is an urgent need develop safer more sustainable pesticides. Industrial hemp a reservoir compounds that could potentially replace some bactericides, fungicides, insecticides. We determined efficacy industrial extracts against Pseudomonas syringae pv. tabaci (PSTA), tomato (PSTO), Erwinia carotovora (EC). The study revealed minimum inhibitory concentration (MIC) 2.05 mg/mL non-inhibitory (NIC) 1.2 for PSTA, MIC 5.7 NIC 0.66 PSTO, 12.04 5.4 EC. Time-kill assays indicated regrowth E. at 4 × after 15 h P. 2 20 h; had no regrowth. susceptibility test bacteria extract can be ordered from most susceptible least susceptible, as follows: > carotovora. Overall, data indicate potential source safe biopesticides major plant pathogens.

Language: Английский

Citations

0