Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice DOI Open Access
Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3147 - 3147

Published: May 27, 2024

Infertility represents a significant global health challenge impacting millions of couples worldwide. Approximately half all infertile exhibit compromised semen quality, indicative diminished male fertility. While the diagnosis infertility traditionally relies on analysis, its limitations in providing comprehensive assessment reproductive have spurred efforts to identify novel biomarkers. Seminal plasma, complex fluid containing proteins, lipids, and metabolites, has emerged as rich source such indicators. Reproduction depends heavily seminal primary transporter chemicals from glands. It provides non-invasive sample for urogenital diagnostics demonstrated potential identification biomarkers linked illnesses system. The abundance proteins enabled deeper understanding their biological functions, origins, differential expression various conditions associated with infertility, including azoospermia, asthenozoospermia, oligozoospermia, teratozoospermia, among others. true prevalence is understated due current diagnostic techniques. This review critically evaluates landscape plasma utility assessing infertility. Βy bridging gap between research clinical practice, integrative offers multimodal approach comprehensively evaluate

Language: Английский

Oxidative Stress and Male Infertility: The Protective Role of Antioxidants DOI Creative Commons
Aris Kaltsas

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1769 - 1769

Published: Oct. 4, 2023

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the role of antioxidants addressing infertility. A detailed examination was conducted on such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, alpha-lipoic acid. analysis examines methodologies, outcomes, constraints current clinical studies. Antioxidants show notable potential counteracting negative effects oxidative sperm. Based evidence, these antioxidants, individually or synergistically, can enhance health outcomes. However, certain limitations studies call for careful interpretation. are integral tackling attributed to stress. The findings underscore their value, yet there’s pressing need deeper, comprehensive research. Future should focus refining dosage guidelines, identifying side effects, discerning most efficacious antioxidant combinations solutions.

Language: Английский

Citations

67
The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation DOI Open Access

Gireeja Walke,

Sagar S Gaurkar, Roshan Prasad

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: July 27, 2023

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, DNA integrity, leading male infertility. Antioxidants play a crucial role in maintaining health by neutralizing ROS protecting cells damage. This review article explores the impact of on investigates potential benefits supplementation mitigating its detrimental effects. A comprehensive literature search was conducted gather relevant studies examining effects fertility outcomes supplementation. The findings reveal that improve some individuals. However, conflicting research limitations study design highlight need for further investigation. Factors such as individual variations, underlying causes infertility, dosage, duration should be carefully considered. Lifestyle modifications, healthy diet exercise, are reducing optimizing health. provides valuable insights into complex relationship function, emphasizing supportive strategy. Further warranted establish optimal protocols, identify specific subgroups may benefit most, explore advancements therapies outcomes.

Language: Английский

Citations

42
Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols DOI Creative Commons

Maria Nunzia De Luca,

Marisa Colone, Riccardo Gambioli

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(8), P. 1283 - 1283

Published: Aug. 13, 2021

Infertility is defined as a couple’s inability to conceive after at least one year of regular unprotected intercourse. This condition has become global health problem affecting approximately 187 million couples worldwide and about half the cases are attributable male factors. Oxidative stress common reason for several conditions associated with infertility. High levels reactive oxygen species (ROS) impair sperm quality by decreasing motility increasing oxidation DNA, protein lipids. Multi-antioxidant supplementation considered effective fertility parameters due synergistic effects antioxidants. Most them act ROS concentration, thus improving quality. In addition, other natural molecules, myo-inositol (MI) d-chiro–inositol (DCI), ameliorate cells, MI involved in many transduction mechanisms that regulate cytoplasmic calcium levels, capacitation mitochondrial function. On hand, DCI downregulation steroidogenic enzyme aromatase, which produces testosterone. this review, we analyze processes involving oxidative action different molecules.

Language: Английский

Citations

74
Role of Antioxidants in Cooled Liquid Storage of Mammal Spermatozoa DOI Creative Commons
Miguel Á. Silvestre, J.L. Yániz, Fernando J. Peña

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1096 - 1096

Published: July 8, 2021

Cooled preservation of semen is usually associated with artificial insemination and genetic improvement programs in livestock species. Several studies have reported an increase reactive oxidative species a decrease antioxidant substances sperm quality parameters during long-term storage at refrigerated temperatures. The supplementation antioxidants extenders before refrigeration could reduce this detrimental effect. Various been tested, both enzymatic, such as superoxide dismutase catalase, non-enzymatic, reduced glutathione, vitamins E C melatonin. However, the problem stress has not fully resolved. effects for semen-cooled reviewed depth. Therefore, objective present study was to review efficiency extender cooled

Language: Английский

Citations

61
Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction DOI
Gokul Sudhakaran,

D. Kesavan,

Karthikeyan Kandaswamy

et al.

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 124, P. 108531 - 108531

Published: Jan. 2, 2024

Language: Английский

Citations

13
Fluoxetine Mitigates Human Sperm Quality by Disrupting the Antioxidant Defense System and Altering the Expression of Apoptosis-Related Genes: An In Vitro Study DOI

Zahra Roostaee,

Malek Soleimani Mehranjani, Ebrahim Cheraghi

et al.

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

1
Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress DOI Creative Commons
Elizabeth Torres-Arce, Bárbara Vizmanos, Nancy Babió

et al.

Biology, Journal Year: 2021, Volume and Issue: 10(3), P. 241 - 241

Published: March 20, 2021

Infertility affects about 15% of the population and male factors only are responsible for ~25–30% cases infertility. Currently, etiology suboptimal semen quality is poorly understood, many environmental genetic factors, including oxidative stress, have been implicated. Oxidative stress an imbalance between production free radicals, or reactive oxygen species (ROS), capacity body to counteract their harmful effects through neutralization by antioxidants. The purpose this review, employing joint expertise international researchers specialized in nutrition fertility areas, update knowledge reproductive consequences excessive ROS concentrations on Assisted Reproduction Techniques (ART) clinical outcomes, discuss role antioxidants finally why foods dietary patterns more innocuous long term solution ameliorating therefore results ART outcomes. Since a narrative review not systematic/meta-analysis, summarized information present study should be considered cautiously.

Language: Английский

Citations

52
Oxidative versus reductive stress: a delicate balance for sperm integrity DOI
Niloofar Sadeghi, Guylain Boissonneault, Marziyeh Tavalaee

et al.

Systems Biology in Reproductive Medicine, Journal Year: 2022, Volume and Issue: 69(1), P. 20 - 31

Published: Oct. 10, 2022

Despite the long-standing notion of “oxidative stress,” as main mediator many diseases including male infertility induced by increased reactive oxygen species (ROS), recent evidence suggests that ROS levels are also “reductive due to over-accumulation reductants. Damaging mechanisms, like guanidine oxidation followed DNA fragmentation, could be observed following reductive stress. Excessive accumulation reductants may arise from excess dietary supplementation over driving one-carbon cycle and transsulfuration pathway, overproduction NADPH through pentose phosphate pathway (PPP), elevated GSH leading impaired mitochondrial oxidation, or a result NADH accumulation. In addition, lower availability oxidized NAD+, glutathione (GSSG), thioredoxins (Trx-S2) induce electron leakage formation hydrogen peroxide (H2O2). level NAD+ impairs poly (ADP-ribose) polymerase (PARP)-regulated repair essential for proper chromatin integrity sperm. Because limited studies regarding possible involvement stress, antioxidant therapy remains central approach in treatment infertility. This review put forward concept stress highlights potential role played vs oxidative at pre-and post-testicular considering supplementation.

Language: Английский

Citations

34
Sperm DNA integrity and male infertility: a narrative review and guide for the reproductive physicians DOI Open Access
Ala’a Farkouh, Gianmaria Salvio, Shinnosuke Kuroda

et al.

Translational Andrology and Urology, Journal Year: 2022, Volume and Issue: 11(7), P. 1023 - 1044

Published: July 1, 2022

Background and Objective: Conventional semen analysis (SA) remains an essential tool in the initial male fertility evaluation subsequent follow-up. However, it neither provides information about functional status of spermatozoa nor addresses disorders such as idiopathic or unexplained infertility (UI). Recently, assessment sperm DNA fragmentation (SDF) has been proposed extended test that may help overcome these inherent limitations basic SA. In this review, we aim to: (I) discuss pathophysiological aspects SDF, including natural repair mechanisms, causes, impact on reproductive outcomes; (II) explain different tools describe potential therapeutic options to manage infertile men with high SDF; (III) analyse strengths, weaknesses, opportunities threats (SWOT) current research topic. Methods: This review was constructed from original studies, systematic reviews meta-analyses were published over years up until August 2021, related various SDF. Key Content Findings: Different mechanisms lead defective chromatin packaging, apoptosis, seminal oxidative stress. The relevance integrity fertility/infertility supported by frequent observation levels SDF men, association risk factors for infertility. Additionally, have inversely correlated outcomes pregnancy assisted reproduction. Terminal deoxynucleotidyl transferase dUTP nick end labelling, structure assay, dispersion, Comet assay are four commonly used assays measurement Addressing lifestyle risks underlying conditions, antioxidants, hormonal therapy, advanced selection techniques all lower Conclusions: sum literature evidence detrimental effects both outcomes. Standardization their incorporation into work couples significant implications future management a selected category

Language: Английский

Citations

29
Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men DOI Open Access

Varinderpal S. Dhillon,

Mohammad Shahid, Permal Deo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 718 - 718

Published: Jan. 5, 2024

Infertility affects millions of couples worldwide and has a profound impact not only on their families, but also communities. Telomere attrition been associated with infertility, DNA damage fragmentation. Oxidative stress shown to affect sperm integrity telomere length. Sirtuins such as SIRT1 SIRT3 are involved in aging oxidative response. The aim the present study is determine role regulating stress, shortening, association oligospermia. Therefore, we assessed protein levels SIRT3, total antioxidant capacity (TAC), superoxide dismutase (SOD), malondialdehyde (MDA) catalase activity (CAT) seminal plasma 272 patients oligospermia 251 fertile men. We measured length (STL) leukocyte (LTL) using standard real-time quantitative PCR assay. Sperm chromatin protamine deficiency were per methods. Our results for oligospermic demonstrate significant reductions semen parameters, shorter STL LTL, lower SOD, TAC, CAT, levels, higher MDA conclude that TL sperms leukocytes increased accounts high fragmentation sperms. support hypothesis various parameters state or caused by reduced proteins.

Language: Английский

Citations

8