Antioxidants,
Journal Year:
2024,
Volume and Issue:
unknown, P. 257 - 283
Published: Nov. 17, 2024
The
chapter
provides
a
comprehensive
overview
of
the
relationship
between
oxidative
stress
and
aging
process.
Oxidative
arises
from
an
imbalance
production
Reactive
Oxygen
Species
(ROS)
body's
antioxidant
defense
system.
mechanisms
action
antioxidants
are
explored,
including
enzymatic
non-enzymatic
antioxidants,
metal-binding
proteins,
dietary
sources,
nutritional
supplements.
also
delves
into
role
in
cellular
senescence
Furthermore,
effectiveness
supplements
combating
is
examined.
highlights
impact
on
skin
health
aging,
discusses
use
topical
anti-aging
cosmetics.
Lifestyle
factors
such
as
exercise,
stress,
sleep,
smoking,
alcohol
consumption
explored
contributors
to
diminished
defense.
concludes
with
discussion
potential
for
personalized
interventions
development
novel
compounds
plants,
marine,
microorganisms,
synthetic
sources
future
research.
Overall,
this
valuable
insights
promoting
healthy
aging.
Food Bioscience,
Journal Year:
2023,
Volume and Issue:
57, P. 103539 - 103539
Published: Dec. 26, 2023
Benign
prostatic
hyperplasia
(BPH)
and
cancer
are
aging-associated
urological
conditions
in
men.
While
significant
advances
have
been
made
relation
to
treatment,
poor
response,
treatment
resistance
adverse
side-effects
limit
currently
available
therapies.
The
possible
antiproliferative
and/or
ameliorative
potentials
of
Juglans
regia
reported,
however,
there
is
a
dearth
scientific
information
on
its
effect
BPH
or
cancer.
In
this
study,
in-vivo
in-vitro
studies
were
used
assess
the
benefits
fresh
walnut
fruits
extract
prostate
High-performance
liquid
chromatography
coupled
with
electro
spray
ionization
quadrupole-time-of-flight
mass
spectrometry
(HPLC-ESI-Q-TOF)
was
chemical
profile
plant
extract.
anti-proliferative
activity
tested
against
normal
cancerous
human
cell
line
by
using
iCELLigence
real-time
label-free
analysis
system.
potential
assessed
administering
at
50
100
mg/kg
body
weight
rats
testosterone
induced
BPH.
Analysis
phytochemicals
revealed
high
concentration
phenolic
acids
flavonoids,
also
showing
time-
dose-dependent
cells,
reversed
biochemical
histomorphological
changes
testosterone-induced
Toxins,
Journal Year:
2022,
Volume and Issue:
14(2), P. 154 - 154
Published: Feb. 19, 2022
Fungi
are
well-known
for
their
abundant
supply
of
metabolites
with
unrivaled
structure
and
promising
bioactivities.
Naphthalenones
among
these
fungal
metabolites,
that
biosynthesized
through
the
1,8-dihydroxy-naphthalene
polyketide
pathway.
They
revealed
a
wide
spectrum
bioactivities,
including
phytotoxic,
neuro-protective,
cytotoxic,
antiviral,
nematocidal,
antimycobacterial,
antimalarial,
antimicrobial,
anti-inflammatory.
The
current
review
emphasizes
reported
naphthalenone
derivatives
produced
by
various
species,
sources,
structures,
biosynthesis,
bioactivities
in
period
from
1972
to
2021.
Overall,
more
than
167
references
159
listed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(10), P. 4192 - 4192
Published: May 19, 2023
The
skin
shows
the
physiological
condition
of
body’s
organs
and
systems
that
prevent
infections
physical
damage.
Throughout
ages,
in
folk
medicine,
phytotherapy
was
considered
a
primary
form
treatment
all
countries,
including
Kazakhstan,
due
to
abundance
availability
plant-based
remedies.
This
paper
discusses
several
medicinal
plants
are
traditionally
used
diseases
Republic
Kazakhstan.
chemical
composition
these
analyzed,
with
particular
focus
on
biologically
active
basic
compounds
responsible
for
their
therapeutic
efficiency
treating
ailments.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(17), P. 5680 - 5680
Published: Sept. 2, 2022
Curcumin's
role
in
the
treatment
of
ulcerative
colitis
(UC)
has
been
proven
by
numerous
studies,
but
its
preventive
administration,
with
aim
reducing
remission
episodes
that
are
characteristic
this
disease,
must
be
further
investigated.
This
study
investigates
effects
a
novel
curcumin-loaded
polymeric
microparticulate
oral-drug-delivery
system
for
colon
targeting
(Col-CUR-MPs)
an
experimental
model
UC.
Male
Wistar
rats
(n
=
40)
were
divided
into
five
groups
8),
which
treated
daily
oral
gavage
seven
days
2%
aqueous
solution
carboxymethylcellulose
sodium
salt
(CMCNa)
(healthy
and
disease
control),
free
curcumin
powder
(reference),
Col-CUR-MPs
(test)
prednisolone
(reference)
prior
to
UC
induction
intrarectal
administration
acetic
acid
(AA),
followed
animal
sacrification
blood
colonic
samples'
collection
on
eighth
day.
exhibited
important
effect
severity
degree
oxidative
stress
resulted
following
AA
was
proved
highest
catalase
(CAT)
total
antioxidant
capacity
(TAC)
levels
lowest
nitrites/nitrates
(NOx),
status
(TOS)
index
(OSI)
levels.
Biochemical
parameter
analysis
supported
histopathological
assessment,
confirming
significant
anti-inflammatory
colon-specific
delivery
AA-induced
rat
models
Thus,
offers
encouraging
perspectives
regarding
form
drug
targeting.
