Skin Aging, Cellular Senescence and Natural Polyphenols

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12641 - 12641

Published: Nov. 23, 2021

The skin, being the barrier organ of body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found accumulate with age may contribute age-related skin changes pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on aging. By affecting molecular pathways senescence, are able prevent or delay senescence formation and, consequently, avoid ameliorate aging age-associated pathologies skin. This review aims provide an overview current state knowledge in cellular summarize recent vitro studies related anti-senescent mechanisms natural carried out keratinocytes, melanocytes fibroblasts. Aged context COVID-19 pandemic will be also discussed.

Language: Английский

---

Natural Compounds and Products from an Anti-Aging Perspective

Molecules, Journal Year: 2022, Volume and Issue: 27(20), P. 7084 - 7084

Published: Oct. 20, 2022

Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.

Language: Английский

---

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Aug. 19, 2022

Human mesenchymal stem cells (MSCs) are primary multipotent capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role MSCs in tissue homeostasis, aging-related diseases, cellular therapy is clinically suggested. As aging a universal problem that has large socioeconomic effects, an improved understanding the concepts can direct public policies reduce its adverse impacts on healthcare system humanity. Several studies have been carried out over several years to understand phenomenon different factors affecting human aging. A reduced ability adult cell populations reproduce regenerate one main contributors process. In this context, senescence major challenge front advancement. Many factors, ranging from genetic metabolic pathways extrinsic through various signaling pathways, involved regulating mechanism MSC senescence. To better reverse senescence, review highlights underlying mechanisms signs discusses strategies combat

Language: Английский

---

Recent Advances in Natural Polyphenol Research

Molecules, Journal Year: 2022, Volume and Issue: 27(24), P. 8777 - 8777

Published: Dec. 11, 2022

Polyphenols are secondary metabolites produced by plants, which contribute to the plant’s defense against abiotic stress conditions (e.g., UV radiation and precipitation), aggression of herbivores, plant pathogens. Epidemiological studies suggest that long-term consumption polyphenols protects cardiovascular disease, cancer, osteoporosis, diabetes, neurodegenerative diseases. Their structural diversity has fascinated confronted analytical chemists on how carry out unambiguous identification, exhaustive recovery from plants organic waste, define their nutritional biological potential. The food, cosmetic, pharmaceutical industries employ fruits vegetables produce additives, additional foods, supplements. In some cases, nanocarriers have been used protect during food processing, solve issues related low water solubility, transport them site action, improve bioavailability. This review summarizes structure-bioactivity relationships, processing parameters impact polyphenol stability bioavailability, research progress in nanocarrier delivery, most innovative methodologies for agri-waste materials.

Language: Английский

---

Polyphenols: Secondary Metabolites with a Biological Impression

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2550 - 2550

Published: Aug. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Language: Английский

---

The medicinal and aromatic plants as ingredients in functional beverage production

Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 96, P. 105210 - 105210

Published: Aug. 9, 2022

The functional beverages (FBs) are an important segment of food products due to health benefits they provide and their appealing sensory characteristics, suitability affordability. FBs market offers many opportunities for new product development (nutraceuticals, colorants, plant-based medicines products) with desirable effective composition nutrients bioactive molecules (BAMs) aimed deliver improve human well-being. Recently, the use medicinal aromatic plants (MAPs) in production has become increasingly popular specific content (amino fatty acids) BAMs (volatile non-volatile) attributed biological effects benefits. stored leaves, flowers, fruits, seeds, barks roots, mostly include phenolics (phenolic acids, flavonoids, tanins, anthocyanins, lignans stilbenes), essential oils (EOs), terpenoids, alkaloids, phytosterols saponins. features MAPs mainly related volatile compounds EOs, but presence non-volatile compounds, such as phenolics, also contributes properties. Phytochemical profiling plant species containing complex mixtures BAMs, provides numerous categories FBs, opens challenges isolation using conventional advanced extraction techniques, well determination potential effects. This review summarizes most common from selected effects, techniques suitable extracts quality prediction trends, several directions towards future research on strategies.

Language: Английский

---

Oxidation Stress as a Mechanism of Aging in Human Erythrocytes: Protective Effect of Quercetin

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7781 - 7781

Published: July 14, 2022

Aging is a multi-factorial process developing through complex net of interactions between biological and cellular mechanisms it involves oxidative stress (OS) as well protein glycation. The aim the present work was to verify protective role Quercetin (Q), polyphenolic flavonoid compound, in d-Galactose (d-Gal)-induced model aging human erythrocytes. anion-exchange capability Band 3 (B3p) measured by rate constant SO42− uptake, thiobarbituric acid reactive substances (TBARS) levels—a marker lipid peroxidation—total sulfhydryl (-SH) groups, glycated hemoglobin (A1c), reduced glutathione/oxidized glutathione (GSH-GSSG) ratio were determined following exposure erythrocytes 100 mM d-Gal for 24 h, with or without pre-incubation 10 µM Q. results confirmed that activated OS pathways erythrocytes, affecting both membrane lipids proteins, denoted increased TBARS levels decreased total respectively. In addition, led an acceleration uptake B3p. Both alteration B3p function damage have been improved pre-treatment Q, which preferentially ameliorated peroxidation rather than oxidation. Moreover, Q prevented A1c formation, while no effect on endogenous antioxidant system observed. These findings suggest could be novel potential target treatments counteract aging-related disturbances. Further studies are needed confirm possible pharmacological strategies against aging.

Language: Английский

---

Antiaging effects of dietary supplements and natural products

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.

Language: Английский

---

Plant-Derived Polyphenols to Prevent and Treat Oral Mucositis Induced by Chemo- and Radiotherapy in Head and Neck Cancers Management

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 260 - 260

Published: Jan. 6, 2024

Oral Mucositis (OM) is the most common side effect due to chemotherapy and radiotherapy, which are conventional treatment options for head neck cancers. OM a severe inflammatory condition characterized by multifactorial etiopathogenesis. It further negatively affects patients' quality of life impairment normal oral functions. Consequently, it mandatory identify new effective therapeutic approaches both prevent treat while also avoiding any recurrence. Polyphenols recently attracted interest scientific community their low toxicity wide range biological activities making them ideal candidates several applications in odontostomatological field, particularly against OM. This review collects vivo studies clinical trials conducted over past 13 years evaluating preventive curative effects polyphenolic compounds towards chemo- radiotherapy-induced OM, when administered alone or as plant-extracted phytocomplex. The literature fully confirms usefulness these molecules, thus opening possibility application. However, polyphenol limitations (e.g., unfavourable physicochemical properties susceptibility degradation) have emerged. should be focused on developing innovative delivery systems able stabilize polyphenols, facilitating topical administration maximizing efficacy.

Language: Английский

---

Nanoformulated phytochemicals in skin anti-aging research: an updated mini review

3 Biotech, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

Language: Английский

---