Indian Journal of Surgical Oncology, Journal Year: 2022, Volume and Issue: 13(4), P. 681 - 690
Published: May 10, 2022
Language: Английский
Medicina, Journal Year: 2023, Volume and Issue: 59(3), P. 594 - 594
Published: March 17, 2023
Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates condition of non-alcoholic (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in period and generally associated a steatosis at least one pathologic among overweight/obesity, type 2 diabetes mellitus, dysregulation. pathogenesis defined by “multiple-hit” model alteration or dysbiosis gut microbiota. The pathogenic role microbiota investigated many diseases, including obesity, NAFLD. However, only few works correlate it MAFLD, although common pathogenetic links to these diseases are suspected. This review underlines most recurrent changes patients while also evidencing possible links.
Language: Английский
Citations
28
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 573 - 573
Published: May 7, 2024
This review comprehensively evaluates the effects of physical exercise on oxidative and nitrosative stress, mainly focusing role antioxidants. Using a narrative synthesis approach, data from empirical studies, reviews, systematic meta-analyses published between 2004 2024 were collated databases like PubMed, EBSCO (EDS), Google Scholar, culminating in inclusion 41 studies. The quality these studies was rigorously assessed to ensure clarity objectives, coherence arguments, comprehensive literature coverage, depth critical analysis. Findings revealed that moderate enhances antioxidant defenses through hormesis, while excessive may exacerbate stress. also highlights natural dietary antioxidants are beneficial, high-dose supplements could impede positive adaptations exercise. In conclusion, calls for more focused research tailored nutrition plans further understand complex interactions optimize health outcomes athletes general population.
Language: Английский
Citations
16
Published: April 11, 2024
This general review assesses the impact of physical exercise on oxidative and nitrosative stress counteractive role antioxidants, drawing from a systematic literature search up to March 2024 in databases like PubMed Web Science. The highlights studies effect production reactive oxygen species (ROS) nitrogen (RNS) antioxidant responses both human animal models based rigorous inclusion exclusion criteria. Due variety types participants' characteristics, narrative synthesis approach was adopted. findings indicate that moderate boosts defenses, known as hormesis, whereas excessive activity may increase damage. also explores complex effects supplementation, revealing while natural dietary antioxidants support health, high-dose supplements could potentially hinder positive adaptations exercise. Recommendations for athletes active population highlight importance balancing intake optimize health benefits. concludes with call more detailed research tailored nutrition plans dissect these intricate relationships further.
Language: Английский
Citations
15
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0316397 - e0316397
Published: Jan. 2, 2025
Background There is increasing acknowledgment of the potential role that diet rich in antioxidants may play prevention anemia. As a significant indicator antioxidant-rich diet, relationship between composite dietary antioxidant index (CDAI) and anemia has not been extensively studied. Therefore, this study aims to explore association CDAI Methods Utilizing datas from 2003–2018 National Health Nutrition Examination Survey (NHANES) database. The was calculated using six antioxidants, based on two 24-hour recall interviews, serving as comprehensive measure intake these antioxidants. Weighted multivariable logistic regression restricted cubic spline (RCS) analysis conducted investigate Furthermore, subgroup analyses were performed enhance reliability. Results A total 33914 participants included study, among which 3,416 (10.07%) diagnosed with unadjusted model showed negative (odds ratio [OR]: 0.94; 95% confidence interval [95%CI]: 0.93–0.96; P < 0.001). After adjusting for all covariates, each increase level linked 3% lower risk (OR: 0.97; 95%CI: 0.95–0.98; Moreover, when categorized into quartiles, observed trend persisted ( RCS revealed linear nonlinearity = 0.619). Except sex, smoking, diabetes hypertension, no statistically interactions found any 0.05 interaction). Conclusion Our findings suggest levels are inversely related prevalence Consequently, monitoring individuals low scores facilitate timely identification clinical decision-making.
Language: Английский
Citations
1
Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 22 - 22
Published: Jan. 6, 2025
Background/Objectives: Managing type 2 diabetes mellitus (T2DM) and obesity requires a multidimensional, patient-centered approach including nutritional interventions (NIs) physical activity. Changes in the gut microbiota (GM) have been linked to metabolic alterations typical of T2DM obesity, they are strongly influenced by diet. However, few studies evaluated effects on GM very-low-calorie ketogenic diet (VLCKD) patients with T2DM, especially mid-term long-term. This longitudinal study is aimed at evaluating long-term impact VLCKD Mediterranean (MD) anthropometric, metabolic, lifestyle parameters 11 (diabesity). extends previously published results short-term (three months) these NIs same patients. Methods: At baseline, were randomly assigned either (KETO group) or (MEDI group). After two months, KETO group gradually shifted (VLCKD-MD), according current guidelines. From fourth month until end both groups followed similar MD. Previous showed that had more beneficial than MD several variables for 3 months NI. In this study, analyses extended six (T6) twelve (T12) NI comparing data prospectively against baseline (T0). The analysis was performed through next-generation sequencing. Results: Improvements anthropometric pronounced T6, particularly body mass index (−5.8 vs. −1.7 kg/m2; p = 0.006) waist circumference (−15.9 −5.2 cm; 0.011). significant improvement HbA1c (6.7% 5.5% 0.02) triglyceride (158 95 mg/dL 0.04) values compared T0 observed only group, which maintained achieved T3. VLCKD-MD phenotype. A substantial positive modulatory effect up sixth due progressive increase bacterial markers human health. month, most health decreased, though still increased baseline. Among them, Verrucomicrobiota phylum identified as main biomarker together its members Verrucomicrobiae, Akkermansiaceae, Verrucomicrobiales, Akkermansia T6 Conclusions: Both dietary approaches ameliorated status, but VLCKD, support MD, has shown greater improvements parameters, well profile,
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 203 - 203
Published: Feb. 10, 2025
The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.
Language: Английский
Citations
1
Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1262 - 1262
Published: March 16, 2022
Smell plays a critical role in food choice and intake by influencing energy balance body weight. Malnutrition problems or modified eating behaviors have been associated with olfactory impairment loss. The obesity epidemic is serious health problem an increased risk of mortality major physical comorbidities. etiopathogenesis complex multifactorial, one the main factors contributing to rapid increase its incidence environment which we live, encourages overconsumption foods rich energy, such as saturated fats sugars. By means "Sniffin' Sticks" test, measured threshold, discrimination identification score (TDI score) patients Obesity Center University Hospital (OC; n = 70) compared them that healthy normal weight controls (HC; 65). OC demonstrated significantly lower function than HC subjects both general specific for ability discriminate identify odors, even when they were considered separately females males. For patients, negative correlation was found between mass index (BMI) scores obtained each subject, divided according gender all together. Besides, normosmic showed BMI hyposmic ones. A reduced sense smell may contribute involving responses cephalic phase, delay achievement satiety excessive high-energy drinks.
Language: Английский
Citations
35
Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9
Published: June 24, 2022
Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels healthy population. In total, 150 volunteers were recruited subjected questionnaires about the last 7-day lifestyle, including smoking habit, food frequency. A panel circulating cytokines, chemokines, growth was analyzed by multiplex ELISA. BMI showed heaviest correlation between LGCI-related cytokines significantly associated with CRP levels. Aging characterized an increase IL-1b, eotaxin, MCP-1, MIP-1α. Smoking related higher IL-1b CCL5/RANTES, while activity Within different eating habits, modulated eggs, red meat, shelled fruits, greens consumption; however, these associations not confirmed multivariate model after adjusting for BMI. Nevertheless, meat consumption inflammatory pattern, IL-6 IL-8. IL-8 also increased frequent intake sweets, fruits correlated lower IL-6. Moreover, formed cluster that included TNF-α. conclusion, BMI, dietary habits are represent potential markers
Language: Английский
Citations
30
Metabolites, Journal Year: 2022, Volume and Issue: 12(11), P. 1092 - 1092
Published: Nov. 10, 2022
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a progressive chronic metabolic disease that has increasingly spread worldwide, enhancing mortality rate, particularly from cardiovascular diseases (CVD). Lifestyle improvement through diet and physical activity is, together with drug treatment, cornerstone T2DM management. The Mediterranean (MD), which favors prevalence unprocessed vegetable foods reduction in red meats industrial foods, without excluding any food category, usually recommended. Recently, scientific societies have promoted very low-calorie ketogenic (VLCKD), multiphasic protocol limits carbohydrates then gradually re-introduces them, favorable outcome on body weight parameters. Indeed, gut microbiota (GM) modifications been linked to overweight/obesity alterations typical T2DM. Diet known affect GM largely, but only few studies investigated effects VLCKD GM, especially In this study, we compared anthropometric, biochemical, lifestyle parameters, quality life, eleven patients recently diagnosed overweight or obesity, randomly assigned two groups six five who followed (KETO) hypocaloric MD (MEDI) respectively; parameters were recorded at baseline (T0) after (T2) three months (T3). results showed had more significant beneficial than anthropometric while biochemical improvements did not statistically differ. As for despite lack regarding alpha beta diversity, Firmicutes/Bacteroidota ratio between groups, KETO group, increase microbial taxa such as Verrucomicrobiota phylum its members Verrucomicrobiae, Verrucomicrobiales, Akkermansiaceae, Akkermansia, Christensenellaceae family, Eubacterium spp., previously associated obesity (Firmicutes Actinobacteriota) other (Alistipes) was observed both T2 T3. With regards MEDI variations limited Actinobacteroidota T3 Firmicutes Moreover, metagenomic alteration some pathways found exclusively group. conclusion, dietary approaches allowed improve their state health, shown better composition well profile.
Language: Английский
Citations
29
Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32803 - e32803
Published: June 1, 2024
Language: Английский
Citations
6