Antioxidant Supplementation on Male Fertility—A Systematic Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 836 - 836

Published: March 30, 2023

Our aim was to review the current literature regarding effect of antioxidant supplementation (AS) on male fertility parameters, as AS is commonly used treat infertility due availability and affordability antioxidants in many parts world. Materials methods: PubMed, Medline, Cochrane electronic bibliographies were searched using modified Preferred Reporting Items for Systemic Reviews Meta-Analyses (PRISMA) guidelines evaluate studies benefit therapy infertile men. Results analyzed following aspects: (a) ingredient dose; (b) potential mechanism action rationale use; (c) various reported outcomes. Results: Thus, 29 found a substantial positive outcomes assisted reproductive (ART), WHO semen live-birth rate. Carnitines, Vitamin E C, N-acetyl cysteine, coenzyme Q10, selenium, zinc, folic acid, lycopene beneficial ingredients. Nevertheless, some did not show change one or more factors. Conclusion: seems have fertility. Environmental factors may play an increasing role Further are needed determine optimal combination influence environmental

Language: Английский

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Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2731 - 2731

Published: May 7, 2024

As global demographics shift toward increasing paternal age, the realm of assisted reproductive technologies (ARTs), particularly in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), faces new challenges opportunities. This study provides a comprehensive exploration implications advanced age on ART outcomes. Background research highlights social, cultural, economic factors driving men later fatherhood, with focus impact delayed paternity Methods involve thorough review existing literature, centering changes testicular function, semen quality, genetic epigenetic shifts associated advancing age. Study results point to intricate associations between father’s outcomes, older being linked diminished potential risks, varied impacts embryo implantation rates, birth The conclusions drawn from current suggest that while presents certain risks challenges, understanding mitigating these through strategies such as cryopreservation, lifestyle modifications, preimplantation testing can optimize Future directions are identified further comprehend mechanisms long-term effects father offspring health. underscores need for approach navigating intricacies fatherhood within context ART, aiming best possible outcomes couples their children.

Language: Английский

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Antioxidant Paradox in Male Infertility: ‘A Blind Eye’ on Inflammation

Antioxidants, Journal Year: 2022, Volume and Issue: 11(1), P. 167 - 167

Published: Jan. 16, 2022

The pathophysiology of male infertility involves various interlinked endogenous pathways. About 50% the cases in men are idiopathic, and oxidative stress (OS) reportedly serves as a central mechanism impairing fertility parameters. antioxidant system operates to conserve seminal redox homeostasis required for normal reproduction. OS strikes when generation reactive oxygen species (ROS) overwhelms capacity. Thus, treatment finds remarkable relevance case idiopathic or subfertility. However, due lack proper detection infertility, use antioxidant(s) some may be arbitrary lead overuse induction 'reductive stress'. Moreover, inflammation is closely linked establish vicious loop that capable disruption reproductive tissues. result exaggeration cellular damage Therefore, limitations therapy treating failure selection specific treatments targeting simultaneously, two core mechanisms infertility. present review aims elucidate paradox treatment, from viewpoints both reductive well overlooking inflammatory consequences.

Language: Английский

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Oxidative versus reductive stress: a delicate balance for sperm integrity

Systems Biology in Reproductive Medicine, Journal Year: 2022, Volume and Issue: 69(1), P. 20 - 31

Published: Oct. 10, 2022

Despite the long-standing notion of “oxidative stress,” as main mediator many diseases including male infertility induced by increased reactive oxygen species (ROS), recent evidence suggests that ROS levels are also “reductive due to over-accumulation reductants. Damaging mechanisms, like guanidine oxidation followed DNA fragmentation, could be observed following reductive stress. Excessive accumulation reductants may arise from excess dietary supplementation over driving one-carbon cycle and transsulfuration pathway, overproduction NADPH through pentose phosphate pathway (PPP), elevated GSH leading impaired mitochondrial oxidation, or a result NADH accumulation. In addition, lower availability oxidized NAD+, glutathione (GSSG), thioredoxins (Trx-S2) induce electron leakage formation hydrogen peroxide (H2O2). level NAD+ impairs poly (ADP-ribose) polymerase (PARP)-regulated repair essential for proper chromatin integrity sperm. Because limited studies regarding possible involvement stress, antioxidant therapy remains central approach in treatment infertility. This review put forward concept stress highlights potential role played vs oxidative at pre-and post-testicular considering supplementation.

Language: Английский

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Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 209 - 209

Published: Sept. 11, 2024

Male infertility is a prevalent issue impacting numerous couples worldwide. This review aims to evaluate the effectiveness of empirical therapies for male infertility, focusing on both lifestyle modifications and medical treatments. study provides comprehensive overview interventions aimed at improving fertility outcomes.

Language: Английский

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Role of Antioxidants of Natural Herbs in Management of Male Infertility

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2023, Volume and Issue: 2(1), P. 55 - 80

Published: Feb. 5, 2023

If you and your spouse have been trying to conceive for a year neither of has successful, there is possibility that are one the 50–80 million people throughout world who struggle with infertility. There male component present in approximately 20%-30% these instances. It common knowledge low-quality sperm oxidative stress (OS) both role aetiology Because oxidation DNA, proteins, lipids, excessive levels reactive oxygen species (ROS) potential disrupt viability, motility, morphology cells. ROS responsible changes. Methods: Through use PubMed interface, we searched MEDLINE database studies had completed published during past ten years analysed effect antioxidants on infertile guys (2012–2022). A number different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, vitamin, were utilised search. The study's findings indicate inositol serves purpose mechanisms foster contacts between oocytes, it also affects OS cells by way its engagement mitochondrial events. Alpha-lipoic acid (ALA) lessens damage caused improves quality ways, morphology, count. might be connection not getting enough zinc diet having sperm. Zinc folate two nutrients can boost quantity When taken orally, Q10 increases as well their overall motility forward movement. therapy selenium (Se) results an improvement sperm's quality, this connected increase ejaculatory production. Only vitamin B12 found improve sperm; does boosting count decreasing DNA damage. Vitamin only proved do this. Conclusions: Dietary supplementation may men semen reducing OS-induced increasing hormone synthesis spermatozoa concentration, morphology. This achieved low semen. Antioxidants exert effects variety ways; hence, important researchers conducting future clinical trials study combining antioxidants.

Language: Английский

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Correlation between viral infections in male semen and infertility: a literature review

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: July 30, 2024

Infertility affects approximately one-sixth of couples globally, with the incidence male infertility steadily increasing. However, our understanding impact viral infections on fertility remains limited. This review consolidates findings from previous studies, outlining 40 viruses identified in human semen and summarizing their key characteristics, modes transmission, effects both reproductive endocrine systems. Furthermore, it elucidates potential pathogenic mechanisms treatment prospects strongly associated infertility. synthesis will enhance comprehension how influence health, offering valuable insights for future research as well diagnosis infectious Abbreviated summary: Semen can damage system, further affecting quality causing infertility, sexually transmitted to partners vertical transmission resulting poor pregnancy outcomes.

Language: Английский

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Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4585 - 4585

Published: Nov. 1, 2022

Lifestyle and environmental factors can negatively impact fertility by means of oxidative stress. In this context, antioxidant supplementation therapy has gained much interest in recent years, different molecules, alone or combination, have been studied. The purpose the present review is to investigate evidence regarding efficacy coenzyme Q10 (CoQ10) melatonin on male infertility. A literature search using PUBMED database from 2000 October 2022 was performed explore role CoQ10 reproductive function. analysis involved a narrative synthesis. CoQ10, appears reduce testicular stress sperm DNA fragmentation improve parameters; particularly motility. Moreover, treatment associated with higher pregnancy rates, both naturally through assisted technology (ART). Larger studies are needed precisely determine its clinical efficacy. Melatonin known preclinical shown ability modulate function hormonal immune system regulation cell proliferation. Regardless, necessary assess potential

Language: Английский

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Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1098 - 1098

Published: May 15, 2023

Spermatozoa are highly differentiated cells that produce reactive oxygen species (ROS) due to aerobic metabolism. Below a certain threshold, ROS important in signal transduction pathways and cellular physiological processes, whereas overproduction damages spermatozoa. Sperm manipulation preparation protocols during assisted reproductive procedures—for example, cryopreservation—can result excessive production, exposing these oxidative damage. Thus, antioxidants relevant topic sperm quality. This narrative review focuses on human spermatozoa as an vitro model study which can be used supplement media. The comprises brief presentation of the structure, general overview main items reduction–oxidation homeostasis ambivalent relationship between ROS. body paper deals with studies have been test antioxidant compounds, including natural extracts. presence synergic effects different molecules could potentially lead more effective products and, future, vivo.

Language: Английский

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The Andrological Landscape in the Twenty-First Century: Making Sense of the Advances in Male Infertility Management for the Busy Clinicians

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(9), P. 1222 - 1222

Published: Sept. 17, 2024

Male infertility represents a significant global problem due to its essential health, social, and economic implications. It is unsurprising that scientific research very active in this area advances the diagnostic therapeutic fields are notable. This review presents main male infertility, starting from changes made latest WHO Manual of semen analysis discussing more molecular aspects inherent “omics”. Furthermore, usefulness artificial intelligence diagnostics varicocele diagnosis will be discussed. In particular, path increasingly moving towards personalized approach search for specific biomarkers prediction treatment response. The remains empirical many regards, but despite that, have been help formulate evidence-based recommendations. Varicocele, most common correctable cause has explored expanded indications repair. following were discussed: elevated sperm DNA fragmentation, hypogonadism, orchalgia, role repair non-obstructive azoospermia. Moving forward with available data, we discussed stepwise surgical retrieval techniques current measures investigated optimizing such patients before testicular extraction. Finally, key points expert recommendations regarding best practice diagnosing treating men summarized conclude review.

Language: Английский

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