Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1769 - 1769

Published: Oct. 4, 2023

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the role of antioxidants addressing infertility. A detailed examination was conducted on such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, alpha-lipoic acid. analysis examines methodologies, outcomes, constraints current clinical studies. Antioxidants show notable potential counteracting negative effects oxidative sperm. Based evidence, these antioxidants, individually or synergistically, can enhance health outcomes. However, certain limitations studies call for careful interpretation. are integral tackling attributed to stress. The findings underscore their value, yet there’s pressing need deeper, comprehensive research. Future should focus refining dosage guidelines, identifying side effects, discerning most efficacious antioxidant combinations solutions.

Language: Английский

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The Impact of Oxidative Stress on Male Reproductive Function: Exploring the Role of Antioxidant Supplementation

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: July 27, 2023

Male reproductive function is highly susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. Oxidative stress can significantly impair sperm quality, including count, motility, morphology, DNA integrity, leading male infertility. Antioxidants play a crucial role in maintaining health by neutralizing ROS protecting cells damage. This review article explores the impact of on investigates potential benefits supplementation mitigating its detrimental effects. A comprehensive literature search was conducted gather relevant studies examining effects fertility outcomes supplementation. The findings reveal that improve some individuals. However, conflicting research limitations study design highlight need for further investigation. Factors such as individual variations, underlying causes infertility, dosage, duration should be carefully considered. Lifestyle modifications, healthy diet exercise, are reducing optimizing health. provides valuable insights into complex relationship function, emphasizing supportive strategy. Further warranted establish optimal protocols, identify specific subgroups may benefit most, explore advancements therapies outcomes.

Language: Английский

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The paternal clock: Uncovering the consequences of advanced paternal age on sperm DNA fragmentation

Reproductive Biology, Journal Year: 2024, Volume and Issue: 24(4), P. 100931 - 100931

Published: Aug. 23, 2024

Language: Английский

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Analysis of research trends (2014-2023) on oxidative stress and male fertility based on bibliometrics and knowledge graphs

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

Background Oxidative stress (OS) is considered one of the major factors affecting male fertility, and research in this field has seen constant growth year by year. Currently, around 700 relevant papers are published each year, with a trend further growth. Therefore, study systematically summarizes literature last decade from bibliometric perspective, revealing dynamic development field, identifying hotspots, analyzing future trends, providing reference for research. Methods Relevant on oxidative fertility was retrieved Web Science Core Collection (WoSCC) database, covering timespan 2014 to 2023 including two types, articles reviews. CiteSpace VOSviewer were used analysis, cluster co-occurrence co-citation burst analysis countries/regions, institutions, journals, authors, references, keywords. Results This paper studied total 5,301 involving 107 China having highest number publications (898 papers) United States centrality (0.62). Burst journal citations revealed emergence many new journals (e.g., Antioxidants-Basel , Front Endocrinol ) after 2021, indicating continuous expansion field. Cluster co-cited references co-occurring keywords divided into areas such as infertility, level detection, antioxidants. The associated hotspots shifted sperm DNA damage, apoptosis, redox potential methylation, embryonic development, infection, polyunsaturated fatty acids, Conclusion Bibliometric methods provide an intuitive reflection process well different periods. Research antioxidant health management, may become

Language: Английский

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The Andrological Landscape in the Twenty-First Century: Making Sense of the Advances in Male Infertility Management for the Busy Clinicians

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(9), P. 1222 - 1222

Published: Sept. 17, 2024

Male infertility represents a significant global problem due to its essential health, social, and economic implications. It is unsurprising that scientific research very active in this area advances the diagnostic therapeutic fields are notable. This review presents main male infertility, starting from changes made latest WHO Manual of semen analysis discussing more molecular aspects inherent “omics”. Furthermore, usefulness artificial intelligence diagnostics varicocele diagnosis will be discussed. In particular, path increasingly moving towards personalized approach search for specific biomarkers prediction treatment response. The remains empirical many regards, but despite that, have been help formulate evidence-based recommendations. Varicocele, most common correctable cause has explored expanded indications repair. following were discussed: elevated sperm DNA fragmentation, hypogonadism, orchalgia, role repair non-obstructive azoospermia. Moving forward with available data, we discussed stepwise surgical retrieval techniques current measures investigated optimizing such patients before testicular extraction. Finally, key points expert recommendations regarding best practice diagnosing treating men summarized conclude review.

Language: Английский

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Protective Effect of B1 and B12 Vitamins on Post‐Thaw Sperm Quality Parameters and Seminal Plasma Antioxidant Status in Rams

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(2)

Published: Feb. 6, 2025

ABSTRACT Background Sperm membranes, rich in polyunsaturated fatty acids, are highly susceptible to lipid peroxidation. Oxidative stress significantly impacts sperm function, and B‐group vitamins play a crucial role mitigating this damage. Objective This study investigated the effects of B1 (VitB1) B12 (VitB12) on quality seminal antioxidant status following cryopreservation Arabi rams. Methods Semen was collected from 10 rams pooled. The pooled semen diluted cryopreserved with varying concentrations VitB1 VitB12 (0, 0.5, 1, 2 4 mg/mL). Post‐thaw parameters, including motility, viability, membrane integrity morphology, were assessed. In addition, enzyme activities peroxidation evaluated. Results Supplementation 1 mg/mL 0.5–1 enhanced post‐thaw morphology. accompanied by reduction malondialdehyde (MDA) levels. highest total capacity (TAC) observed 0.5 ( p < 0.05), positively correlating motility viability 0.01). Glutathione peroxidase (GPx) activity groups negatively correlated abnormalities Catalase (CAT) increased 1–2 0.5–2 groups, progressive Conclusions These findings demonstrate that incorporating into extender effectively mitigates oxidative stress, enhances defences improves

Language: Английский

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Oxidative Stress and Male Subfertility: Recent Detection Methodologies

Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The high concentrations of ROS/RNS/RSS free radicals and neutral compounds have a negative effect on human fertility, both in men women. overall result is known as oxidative stress, which also impacts male infertility has been confirmed animal models infertile by basic semen analysis. Determination stress not routine test, but its consequences are diagnosed indirectly the low values parameters poor sperm function assessing man’s lifestyle. According to plethora epidemiology/clinical data, could be reduced radical lifestyle interventions such antioxidant nutrition intake, weight loss, smoking alcohol cessation. This chapter presents reactive species generation; their crucial relation/mechanisms with body disorders/diseases, general; more specific lab measurements (e.g., decrease analysis, increase DNA fragmentation apoptosis). Special mention will made toward trace elements Zn, Se, Cu’s importance reproductive system.

Language: Английский

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Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 478 - 478

Published: March 25, 2025

Oxidative stress is a significant factor that contributes to male infertility and sperm dysfunction. In this condition, an increase in ROS production exceeds the body's antioxidant defenses, resulting decline spermatozoa quality fertilizing capacity. Furthermore, excessive has been linked promotion of genomic damage, lipid peroxidation, inflammation, altered enzyme activity, ultimately, irreversible alterations, cell death, seminal parameters associated with infertility. It established physical activity (PA), acting on inflammatory improving defense, can alleviate negative effects caused by free radicals, offering numerous health benefits positively influencing quality. The objective review highlight mechanisms production, physiological pathophysiological roles relation reproductive system, recent knowledge impact some protocols PA these systems molecular involved.

Language: Английский

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Exploring the interplay between inflammation and male fertility

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Male fertility results from a complex interplay of physiological, environmental, and genetic factors. It is conditioned by the properly developed anatomy reproductive system, hormonal regulation balance, between different cell populations that sustain an appropriate functional environment in testes. Unfortunately, mechanisms sustaining male are not flawless their perturbation can lead to infertility. Inflammation one factors contribute In testes, it be brought on varicocele, obesity, gonadal infections, leukocytospermia, physical obstructions or traumas, consumption toxic substances. As result prolonged untreated inflammation, testicular resident cells spermatogenesis suffer DNA damage, lipid protein oxidation, mitochondrial dysfunction consequently leading loss function affected Sertoli (SCs) Leydig (LCs), formation morphologically abnormal dysfunctional sperm lay basis infertility subfertility. This due mainly production secretion pro-inflammatory mediators, including cytokines, chemokines, reactive oxygen species (ROS) local immune (macrophages, lymphocytes T, mast cells) tissue-specific [SCs, LCs, peritubular myoid (PMCs) germ (GCs)]. Depending location, duration, intensity these mediators exert effect elements this review, we discuss most prevalent inflammatory negatively affect describe ways inflammation impair function.

Language: Английский

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Micronutrient–Antioxidant Therapy and Male Fertility Improvement During ART Cycles

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 324 - 324

Published: Jan. 17, 2025

Today, accumulating evidence highlights the impact of oxidative stress (OS) on semen quality. It is considered to be a key factor contributing decline in male fertility. OS detected 30-80% men with infertility, highlighting its strong association impaired reproductive function and clinical outcomes following use assisted technologies. Spermatozoa are particularly vulnerable damage due their high content polyunsaturated fatty acids (PUFAs) limited antioxidant defense abilities. arises from an imbalance between production reactive oxygen species capacity neutralize or repair adverse effects. Evidence indicates that leads lipid peroxidation, protein oxidation, mitochondrial dysfunction, genomic instability. Micronutrient-antioxidant therapies can play role infertility improvement by neutralizing free radicals preventing cellular damage. Many different micronutrients, including L-carnitine, L-glutathione, coenzyme Q10, selenium, zinc, as well vitamins complexes, proposed improve sperm parameters fertility potential. This study aims review supplementation parameters, volume, motility, concentration, morphology, genome integrity (maturity fragmentation), vitro fertilization (IVF) outcomes. Antioxidant intake balanced lifestyle reduce enhancing spermatogenesis spermiogenesis processes, improving quality, protecting DNA integrity.

Language: Английский

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