Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 2072 - 2072

Published: July 23, 2023

Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. results in impaired tissue repair remodeling, loss physiological integrity, organ dysfunction, changes the secretome. The systemic accumulation cells has been observed many age-related diseases. Likewise, cellular implicated as risk factor driving mechanism chronic obstructive pulmonary disease (COPD) pathogenesis. Airway epithelium exhibits hallmark features COPD including activation p53/p21WAF1/CIP1 p16INK4A/RB pathways, leading to arrest. epithelial senescent secrete an array inflammatory mediators, so-called senescence-associated secretory phenotype (SASP), persistent low-grade inflammation COPD. SASP further promotes autocrine paracrine manner, potentially contributing onset progression In addition, airway associated with telomere DNA damage, oxidative stress. This review discusses potential mechanisms COPD, impact on development severity disease, highlights targets for modulating therapeutic approach

Language: Английский

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XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1933 - 1933

Published: Oct. 30, 2023

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When redox balance remains undisturbed, plays role physiological adaptations and signal transduction. However, during aging process, increased cellular senescence reduced levels endogenous antioxidants cause an imbalance cardiorenal system. Recent studies from our laboratory others indicated that these age-related diseases caused by are guided controlled versatile network composed diversified pathways. In this review, we describe mechanisms link range disorders, including mitochondrial instability, inflammation, alterations neurohumoral drive. Furthermore, propose differing degrees activation may beneficial or harmful effects Gaining comprehensive understanding how exerts influence on system regulating will enhance ability to provide new directions strategies for cardiovascular renal safety outcomes.

Language: Английский

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Advances in otolith-related protein research

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 26, 2022

Otoliths are biological crystals formed by a layer of calcium carbonate crystal that adhere to the ciliary surface utricular and saccular receptors in vestibule all vertebrates inner ear, enabling utricle saccule better perceive changes linear gravitational acceleration. However, molecular etiology otolith related diseases is still unclear. In this review, we have summarized recent findings provided an overview proteins play important roles formation maintenance (Otoconin-90, Otolin-1, Otolith Matrix Protein-1, Cochlin, Otogelin, α-Tectorin, β-Tectorin, Otopetrin-1, Otopetrin-2, PMCA2, etc.), providing new insight for prevention management benign paroxysmal positional vertigo (BPPV) with basis otolith-related as potential biomarkers vestibular disease.

Language: Английский

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Senotherapy for lung diseases

Advances in pharmacology, Journal Year: 2023, Volume and Issue: unknown, P. 249 - 271

Published: Jan. 1, 2023

Language: Английский

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The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD

Published: May 1, 2023

Oxidative stress driven by several environmental and local airway factors associated with chronic obstructive bronchiolitis, a hallmark feature of COPD, plays crucial role in the disease pathomechanism. Unbalance between oxidants antioxidant defense mechanisms not only amplifies inflammatory processes, but it also worsens cardiovascular health contribute to COPD related dysfunctions mortality. The current review summarizes recent developments our understanding different contributing oxidative its countermeasures special attention those that link systemic processes. Major regulatory orchestrating these pathways are introduced together some suggestions for further research on field.

Language: Английский

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Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity

Journal of Asthma and Allergy, Journal Year: 2023, Volume and Issue: Volume 16, P. 481 - 499

Published: May 1, 2023

Abstract: 20 million adults and 4.2 children in the United States have asthma, a disease resulting inflammation airway obstruction response to various factors, including allergens pollutants nonallergic triggers. Obesity, another highly prevalent US, is major risk factor for asthma significant cause of oxidative stress throughout body. People with comorbid obesity are susceptible developing severe that cannot be sufficiently controlled current treatments. More research needed understand how pathobiology affected when patient has obesity. Because epithelium directly interacts outside environment closely immune system, understanding patients altered compared lean will crucial more effective In this review, we discuss plays role two chronic inflammatory diseases, propose mechanism these conditions may compromise epithelium. Keywords: permeability, obesity,

Language: Английский

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Chronic obstructive pulmonary disease and the modulation of CFTR by acute exposure to cigarette smoke

AJP Cell Physiology, Journal Year: 2022, Volume and Issue: 323(5), P. C1374 - C1392

Published: Sept. 19, 2022

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and cigarette smoke the main risk factor. Detecting its earliest stages preventing decline in lung function are key goals. The pathogenesis COPD complex but has some similarities to cystic fibrosis (CF), caused by mutations cftr gene. CF leads chronic inflammation, abnormal mucus, cycles infection. Cigarette exposure also causes CFTR dysfunction, it probably not coincidence that mucus obstruction, infections characteristics COPD, although exacerbations can be quite different. We review here acute effects on potential role COPD. Understanding regulation may identify novel drug targets facilitate development therapeutics reduce progression severity

Language: Английский

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Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Journal of Clinical Biochemistry and Nutrition, Journal Year: 2022, Volume and Issue: 72(1), P. 13 - 22

Published: Oct. 17, 2022

Although many diseases in which reactive oxygen species (ROS) and free radicals are involved their pathogenesis known, antioxidants that effectively capture ROS have been identified developed, there only a few for used treatment. Here, we discuss on the following four concepts regarding development of applications disease treatment by regulating ROS, radicals, lipid oxidation with findings our research previous reports. Concept 1) Utilization In particular, importance timing starting antioxidant will be discussed. 2) Therapeutic strategies using radicals. Methods inducing ferroptosis, has advocated as an iron-dependent cell death, mentioned. 3) Treatment drugs inhibit synthesis mediators. addition to reduction inflammatory mediators inhibiting cyclooxygenase leukotriene synthesis, introduce possibility lipoxygenase inhibitors. 4) Disease production useful control. We describe utilizing pro-resolving propose potential compounds activate produce these beneficial

Language: Английский

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Bufei Huoxue capsule attenuates COPD-related inflammation and regulates intestinal microflora, metabolites

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 9, 2024

Bufei Huoxue capsule (BFHX) is widely used for the clinical treatment of chronic obstructive pulmonary disease (COPD) in China.

Language: Английский

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Nrf2: The Guardian of Cellular Harmony – Unveiling Its Role in Cell Biology and Senescence

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Nrf2, a key cellular regulator, plays complex and multifaceted role in both protecting healthy cells potentially promoting disease progression. This chapter delves into the intricate mechanisms by which Nrf2 exerts its protective effects, including combating carcinogens, maintaining integrity, inducing controlled cell death under severe stress. However, also explores “dark side” of where activity cancer can contribute to chemoresistance, adaptation, growth, hindering effective treatment. The further investigates current research avenues for harnessing Nrf2’s potential therapeutic benefit. Strategies activation inhibition are explored, highlighting importance context-dependent balancing protection harm, minimizing off-target effects. Promising new directions, such as developing tissue-specific modulators, identifying predictive biomarkers, combining modulators with other approaches, discussed. By understanding roles, we pave way development safer more strategies that leverage beneficial effects while mitigating drawbacks various diseases.

Language: Английский

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