Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(6)
Published: June 25, 2023
Psoriasis cannot be completely cured and is often difficult to diagnose, which why the search for new effective therapies diagnostics a highly relevant area of research. To identify therapeutic compounds, first step study role various factors underlying development psoriasis. One such factor oxidative stress. In this review, we will consider stress at different stages psoriasis development, as well biomarkers that can potentially used in diagnosis antioxidants, are likely applied treatment disease.
Language: Английский
Citations
15
Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102729 - 102729
Published: May 2, 2023
Psoriasis, one of the most frequent immune-mediated skin diseases, is manifested by numerous psoriatic lessons on caused excessive proliferation and keratinization epidermal cells. These disorders keratinocyte metabolism are a pathological interaction with cells immune system, including lymphocytes, which in psoriasis also responsible for systemic inflammation. This accompanied oxidative stress, promotes formation lipid peroxidation products, reactive aldehydes isoprostanes, additional pro-inflammatory signaling molecules. Therefore, presented review focused highlighting changes that occur during development at level 4-hydroxynonenal, 4-oxononenal, malondialdehyde, acrolein, their influence protein structures. Furthermore, we will examine inducing agents cellular functioning, as well intercellular signaling. products can form adducts variety proteins different functions body, within system. especially true autoimmune diseases such psoriasis. For example, these concern involved maintaining redox homeostasis or should attract attention, design preventive cosmetics anti-psoriasis therapies.
Language: Английский
Citations
14
Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(5), P. 100846 - 100846
Published: Sept. 1, 2023
Psoriasis is an inflammatory skin disease that intricately linked to oxidative stress. Antioxidation and inhibition of abnormal proliferation keratinocytes are pivotal strategies for psoriasis. Delivering drugs with these effects the site lesions a challenge needs be solved. Herein, we reported nanotransdermal delivery system composed all-trans retinoic acid (TRA), triphenylphosphine (TPP)-modified cerium oxide (CeO2) nanoparticles, flexible nanoliposomes gels (TCeO2-TRA-FNL-Gel). The results revealed TCeO2 synthesized by anti-micelle method, size approximately 5 nm, possessed excellent mitochondrial targeting ability valence conversion capability related scavenging reactive oxygen species (ROS). TCeO2-TRA-FNL prepared film dispersion 70 showed high drug encapsulation efficiency (>96%). TCeO2-TRA-FNL-Gel further sustained release behaviors, great transdermal permeation ability, greater retention than free TRA. in vitro EGF-induced H2O2-induced models suggested effectively reduced level inflammation alleviated stress HaCat cells. vivo imiquimod (IMQ)-induced model indicated could greatly alleviate psoriasis symptoms. In summary, designed this study has shown therapeutic on prospective safe accurate therapy
Language: Английский
Citations
13
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Nov. 15, 2023
Psoriasis is a systemic inflammatory disease that frequently coexists with various other conditions, such as essential hypertension, diabetes, metabolic syndrome, and bowel disease. The association between these diseases may be attributed to shared pathways abnormal immunomodulatory mechanisms. Furthermore, metabolites also play regulatory role in the function of different immune cells involved psoriasis pathogenesis, particularly T lymphocytes. In this review, we have summarized current research progress on cell metabolism psoriasis, encompassing regulation glucose metabolism, lipid amino acid within affected by psoriasis. We will explore interaction mechanism psoriatic cells. Moreover, further discussed metabolomics gain deeper understanding its pathogenesis identify potential new therapeutic targets through identification biomarkers associated condition.
Language: Английский
Citations
13
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 11, 2024
Objective To explore the influence of serum metabolites on risk psoriasis. Methods In initial stage, we applied Mendelian randomization to evaluate association between 1,400 and Causal effects were primarily assessed through Inverse-Variance Weighted method Wald Ratio’s odds ratios, 95% confidence intervals. False Discovery Rate was used for multiple comparison corrections. Sensitivity analyses conducted using Cochran’s Q Test, MR-PRESSO. MR-Steiger Test employed check reverse causality. validation sought other sources psoriasis GWAS data verify results meta-analysis combine effect sizes obtain robust causal relationships. addition, also metabolic pathway enrichment analysis known that have a relationship with in both stages. Results identified 112 causally associated psoriasis, including 32 metabolite ratios 80 (69 11 unknown). 24 (16 known, 1 unknown, 7 ratios) confirmed onset. Meta-analysis showed overall combined consistent main direction Of 16 metabolites, most attributed lipid metabolism, 5 as factors 8 protective Peptidic Gamma-glutamylvaline levels had negative while exogenous Catechol sulfate amino acid 3-methylglutaconate positive disease The two stages are mainly enriched following pathways: Glutathione Alpha Linolenic Acid Linoleic Metabolism, Biosynthesis unsaturated fatty acids, Arachidonic Glycerophospholipid metabolism. Conclusion Circulating may potential risk, targeting specific benefit diagnosis, assessment, treatment.
Language: Английский
Citations
5
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(4), P. 153 - 153
Published: April 18, 2024
Oxidative stress often affects the structure and metabolism of lipids, which in case polyunsaturated free fatty acids (PUFAs) leads to a self-catalysed chain reaction lipid peroxidation (LPO). The LPO PUFAs formation various aldehydes, such as malondialdehyde, 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, 4-oxo-2-nonenal. Among reactive 4-HNE is major bioactive product LPO, has high affinity for binding proteins. This review briefly discusses available information on applicability assessment options its protein adducts determined by immunosorbent assay (the 4-HNE-ELISA) patients with diseases known be associated oxidative stress, 4-HNE. Despite differences protocols applied antibodies used, all studies confirmed usefulness 4-HNE-ELISA research purposes. Since different used could give values when same samples, should combined other complementary analytical methods allow comparisons between obtained healthy individuals. large variations, reviewed this paper have mostly shown significantly increased levels 4-HNE-protein samples from compared As any biomarker studied patients, it preferred perform not only single-time analysis but measurements at multiple time points monitor dynamics occurrence systemic response disease causing it. especially important acute diseases, individual blood can fluctuate more than threefold within few days depending state health, was COVID-19 patients.
Language: Английский
Citations
5
Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, oxidative stress, and immune dysregulation. In this study, we developed multifunctional, double-network hydrogel, composed of chitosan poly(acrylic acid), embedded with cerium oxide nanoparticles (CeNPs) betamethasone. The hydrogel harnesses the redox-catalytic properties CeNPs to scavenge reactive oxygen species (ROS) while ensuring sustained betamethasone release for antibacterial anti-inflammatory effects. Its mechanical stability high water retention make it suitable long-term application. vitro, enhanced viability under stress showed significant activity against Escherichia coli. psoriasis-induced mouse model, significantly reduced epidermal hyperplasia, suppressed proliferation, lowered cytokine levels. combination antioxidant, antibacterial, suggests that offers promising therapeutic strategy psoriasis, addressing both inflammation effective treatment.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1875 - 1875
Published: Oct. 18, 2023
Aim: There are no studies regarding comparative analysis of serum biomarkers oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the redox homeostasis parameters PsO vs. AD an attempt find sensitive specific biomarker that could best reflect existence one these disease entities. Methods: Forty forty were consecutively included this cross-sectional study. Parameters homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) advanced oxidation protein products (AOPP)] antioxidants [catalase (CAT) superoxide dismutase (SOD)] determined. Results: was difference between group, except for higher CAT activity group (p < 0.001). Among all examined biomarkers, ROC showed only exhibited good diagnostic accuracy (AUC = 0.719) discrimination AD, 0.436 U/L as cut-off value activity. Conclusions: The from those PsO. obtained results suggest importance use a potential therapeutic strategy treatment two skin inflammatory diseases.
Language: Английский
Citations
11
Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 692 - 692
Published: Feb. 14, 2025
Background/Objectives. Psoriasis is a common chronic skin inflammatory disorder pathogenetically associated with genetic, environmental, and immunological factors. The hallmarks of psoriatic lesions include sustained inflammation related to alterations in the innate adaptive immune response, uncontrolled keratinocyte proliferation, differentiation, death, as well dysregulated crosstalk between cells keratinocytes. In search novel therapeutic strategies based on use natural products dietary components combine available conventional innovative therapeutics, we explored anti-inflammatory, antioxidant, immunomodulatory activities Curcumin (CU)-based solid lipid nanoparticles (SLNs) carrying omega-3 fatty acid linolenic (LNA) an vitro model psoriasis that had been previously constructed characterized by us. Methods. This consists differentiated THP-1 macrophages (Mφs) NCTC-2544 keratinocytes exposed or not conditioned medium (CM) from Mφs treated Toll-like receptor-7 ligand imiquimod (IMQ). Results. Mφs, treatment CU-LNA-SLNs inhibited IMQ-induced expression proinflammatory cytokines (IL-23, IL-8, IL-6: 43%, 26.5% 73.7% inhibition, respectively, vs IMQ-treated Mφs), hyperproliferative response (12.8% inhibition Mφs) increase cell death observed Mφ-derived CM (64.7% inhibition). Moreover, same conditions, reverted control levels increased two markers ferroptosis, form recently involved pathogenesis (TFRC MDA: 13.4% 56.1% respectively). Conclusions. These results suggest could inhibit inflammation, hyperproliferation lesions, be considered new possible strategy for further evaluated topic vivo.
Language: Английский
Citations
0