Cell death regulation: A new way for natural products to treat osteoporosis

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106635 - 106635

Published: Dec. 26, 2022

Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within bone. Intra-bone dependent on precise dynamic balance between resorption by osteoclasts and formation mesenchymal lineage osteoblasts, which comprises series complex highly standardized steps. Programmed cell death (PCD) (e.g., apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis) process involves cascade gene expression events with tight structures. These play certain role in regulating metabolism determining fate cells. Moreover, existing research has suggested natural products derived wide variety dietary components medicinal plants modulate PCDs based different mechanisms, show great potential for prevention treatment osteoporosis, thus revealing emergence more acceptable complementary alternative drugs lower costs, fewer side effects long-term application. Accordingly, this review summarizes types field osteoporosis. perspective targeting PCDs, also discussed roles currently reported osteoporosis involved mechanisms. Based this, provides insights into new molecular mechanisms reference developing anti-osteoporosis future.

Language: Английский

---

Advances in materials-based therapeutic strategies against osteoporosis

Biomaterials, Journal Year: 2023, Volume and Issue: 296, P. 122066 - 122066

Published: Feb. 20, 2023

Language: Английский

---

Insights and implications of sexual dimorphism in osteoporosis

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 18, 2024

Osteoporosis, a metabolic bone disease characterized by low mineral density and deterioration of microarchitecture, has led to high risk fatal osteoporotic fractures worldwide. Accumulating evidence revealed that sexual dimorphism is notable feature osteoporosis, with sex-specific differences in epidemiology pathogenesis. Specifically, females are more susceptible than males while prone disability or death from the disease. To date, sex chromosome abnormalities steroid hormones have been proven contribute greatly osteoporosis regulating functions cells. Understanding its related complications essential for improving treatment strategies tailored women men. This literature review focuses on mechanisms underlying mainly population aging patients, chronic glucocorticoid administration, diabetes. Moreover, we highlight implications developing therapeutics preventive screening approaches Additionally, challenges translating bench research bedside treatments future directions overcome these obstacles will be discussed.

Language: Английский

---

A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 14, 2022

Recently, the increasing prevalence of diabetes mellitus has made it a major chronic illness which poses substantial threat to human health. The osteoporosis among patients with grown considerably. Diabetic bone disease is secondary induced by mellitus. Patients diabetic exhibit variable degrees loss, low mineral density, microarchitecture degradation, and increased fragility continued mellitus, their risk fracture impairing ability heal after fractures. At present, there extensive research interest in many significant outcomes have been reported. However, are no comprehensive review This elaborates on aspects characteristics, pathogenesis, treatment.

Language: Английский

---

ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1050 - 1050

Published: June 28, 2023

Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by accumulation of misfolded proteins. During osteoclastogenesis, a large number active proteins synthesized. When an imbalance in folding process occurs, it causes osteoclasts to trigger UPR. This close association has led role UPR osteoclastogenesis being increasingly explored. In recent years, several studies have reported ER bone resorption. Here, we reviewed relevant literature discussed signaling cascade response, osteoclastogenesis-related pathways, resorption detail. It was found that signal (PERK, CHOP, IRE1-XBP1) promoted expression receptor activator nuclear factor-kappa B ligand (RANKL) osteoblasts indirectly enhanced osteoclastogenesis. IRE1 via promoting NF-κB, MAPK signaling, or release pro-inflammatory factors (IL-6, IL-1β, TNFα). CREBH osteoclast differentiation NFATc1 expression. The PERK pathway also through NF-κB autophagy, RANKL secretion from osteoblasts. However, salubrinal (an inhibitor eIF2α dephosphorylation upregulated p-eIF2α expression) directly inhibited suppressing Therefore, specific effects mechanisms p-PERK downstream on still need further experiments confirm. addition, exact ATF6 BiP required exploration. conclusion, our detailed systematic review provides some references for next step fully elucidate relationship between intending provide new insights treatment diseases caused over-differentiation, such as osteoporosis.

Language: Английский

---

Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 703 - 727

Published: March 19, 2024

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden unwanted side effects. In this context, hybrid systems artfully harnessing virtues liposomes hydrogels bring remarkable benefits, especially for localized therapy, including intensified stability, excellent amenability to hydrophobic hydrophilic medications, controlled liberation behavior, appropriate mucoadhesion mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks attracted unprecedented interest in tissue regeneration, given their tunable architecture physicochemical properties, well enhanced mechanical support. This review elucidates presents cutting-edge developments recruiting treatment regeneration.

Language: Английский

---

Bone tissue engineering for osteointegration: Where are we now?

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(10), P. 8595 - 8605

Published: Feb. 3, 2024

Abstract Bone fracture healing is a challenging process, due to insufficient and slow tissue repair. Sufferers from bone fractures struggle with one-third of nonunion, display graft rejection, high-costed implantation, or chronic pain. Novel advances in engineering presented promising options for this strain. Biomaterials repair allow accelerated regeneration, osteoblastic cell activation, enhanced remodeling. There wide range biomaterials that are biocompatible, bioresorbable, biodegradable used promoting osteoconductive osteoinductive properties. The main aim generate rapid optimal functional regeneration through combination biomaterials, growth factors, cells, various agents. Recently has been attracted the use bioactive glass scaffolds incorporated polymers patient-specific fabrication material by 3D bioprinting. future outcomes were reported several research. present review provides an outlook recent most common suggesting practices should have proceeded clinical application.

Language: Английский

---

Identification of ferroptosis-associated biomarkers for the potential diagnosis and treatment of postmenopausal osteoporosis

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 29, 2022

Objective Postmenopausal osteoporosis (PMOP) is one of the most commonly occurring conditions worldwide and characterized by estrogen deficiency as well persistent calcium loss with age. The aim our study was to identify significant ferroptosis-associated biomarkers for PMOP. Methods materials We obtained training dataset from Gene Expression Omnibus (GEO) database using GSE56815 expression profiling data. Meanwhile, we extracted genes further analysis. Differentially expressed (DEFAGs) between OP patients normal controls were selected “limma” package. established a gene signature models, specifically, random forest (RF) support vector machine (SVM) models. It validated in another (GSE56814) which also showed high AUC: 0.98, indicating diagnostic value. Using consensus clustering, patient subtypes identified. A ferroptosis associated (FAG)-Scoring scheme developed PCA. important candidate compared different ferrclusters geneclusters. Results There DEFAGs acquired, five (HMOX1, HAMP, LPIN1, MAP3K5, FLT3) establishing signature. Analyzed ROC curve, RF model had higher AUC value than SVM (RF AUC:1.00). Considering these results, chosen be appropriate model. Later, based on levels DEFAGs, clinical application nomogram established. divided into two (ferrcluster A, B genecluster B, respectively) according clustering method differentially (DEGs). Ferrcluster score ferrcluster respectively. COL1A1 significantly gencluster respectively, while there no statistical difference term VDR gene, COL1A2 genes, PTH expressions together B. Conclusions On basis explanatory variables MAP3K5 FLT3), identified differently categorized that may potentially applied early diagnosis individualized treatment ER IL-6 are OP, however, more studies still anticipated elucidate relationship OP.

Language: Английский

---

Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels

Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 416 - 416

Published: Jan. 12, 2023

Thermosensitive chitosan/collagen hydrogels are osteoconductive and injectable materials. In this study, we aimed to improve these properties by adjusting the ratio of nanohydroxyapatite particles calcium carbonate microcapsules in a β-glycerophosphate-crosslinked hydrogel. Two hydrogel systems with 2% 5% were studied, each which had varying microcapsule content (i.e., 0%, 1%, 2%, 5%). Quercetin-incorporated prepared. Calcium then added according composition studied system. The hydrogels, including cytotoxicity biocompatibility, investigated mice. 2-6 µm size, spherical, rough nanoporous surfaces, thus exhibited burst release impregnated quercetin. system is solid particulate gel that supports homogeneous distribution three-dimensional matrix hydrogels. increased mechanical physical strength, viscoelasticity, stability while decreasing their porosity, swelling, degradation rates. microcapsules-nanohydroxyapatite noncytotoxic biocompatible. can be tailored particles. 1% containing particle-chitosan/collagen permeability, prolonged profiles quercetin, superior those other optimal for promoting bone regeneration delivering natural flavonoids.

Language: Английский

---

A Single‐Cell RNA Sequencing Guided Multienzymatic Hydrogel Design for Self‐Regenerative Repair in Diabetic Mandibular Defects

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Conventional bone tissue engineering materials struggle to reinstate physiological remodeling in a diabetic context, primarily due the compromised repolarization of proinflammatory macrophages anti-inflammatory macrophages. Here, leveraging single-cell RNA sequencing (scRNA-seq) technology, pivotal role nitric oxide (NO) and reactive oxygen species (ROS) is unveiled impeding macrophage during amidst diabetes. Guided by scRNA-seq analysis, we engineer multienzymatic hydrogel scaffold (MEBTHS) composed engineered methylpropenylated gelatin integrated with ruthenium nanozymes, possessing both Ru

Language: Английский

---