Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236

Published: Aug. 16, 2022

Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.

Language: Английский

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Biofilm and wound healing: from bench to bedside

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: April 25, 2023

Abstract The bubbling community of microorganisms, consisting diverse colonies encased in a self-produced protective matrix and playing an essential role the persistence infection antimicrobial resistance, is often referred to as biofilm. Although apparently indolent, biofilm involves not only inanimate surfaces but also living tissue, making it truly ubiquitous. mechanism formation, its growth, development resistance are ever-intriguing subjects yet be completely deciphered. abundance studies recent years has focused on various ways create potential anti-biofilm therapeutics, dearth clear standard clinical practice remains, therefore, there essentially need for translating laboratory research novel bedside strategies that can provide better outcome. Of significance, responsible faulty wound healing chronicity. experimental report prevalence chronic wounds anywhere between 20 100%, which makes topic significant concern healing. ongoing scientific endeavor comprehensively understand interaction with generate standardized measures reproducible setting challenge hour. In this context “more needs done”, we aim explore effective clinically meaningful methods currently available management how these tools translated into safe practice.

Language: Английский

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Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8874 - 8874

Published: May 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Language: Английский

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Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 331 - 331

Published: March 8, 2024

Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, lipid-lowering effects, in addition thermogenic capacity. While intake dietary sources such as curry may be sufficient affect intestinal microbiome thus act indirectly, intact curcumin body too low (<1 microM) not signaling gene expression, observed vitro with cultured cells (10–20 microM). Several strategies can envisioned increase levels body, decreasing metabolism or absorption through formation nanoparticles. However, since high could also lead undesired regulatory effects on cellular studies need carefully monitored. Here, we review bioavailability what extent using nanoformulations bioactivity metabolites. This enhancement potentially amplify disease-preventing curcumin, often by leveraging robust antioxidant properties.

Language: Английский

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Chemical Composition of Turmeric (Curcuma longa L.) Ethanol Extract and Its Antimicrobial Activities and Free Radical Scavenging Capacities

Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1550 - 1550

Published: May 16, 2024

Turmeric (Curcuma longa L.) is a perennial tuberous plant from the genus Curcuma (Zingiberaceae) and has been widely used in foods for thousands of years. The present study examined ethanol extract turmeric its chemical composition, antimicrobial activity, free radical scavenging properties. UHPLC-MS/MS analysis tentatively identified eight compounds extract. Potential effects 0.1, 1.0, 10 mg equivalents (TE)/mL were evaluated vitro against variety Gram-negative bacteria (i.e., Escherichia coli, Klebsiella pneumoniae, Pseudomonas sp.) Gram-positive Enterococcus faecalis, Listeria innocua, Staphylococcus aureus). Concentrations 0.1 1.0 TE/mL inhibited growth S. aureus significantly suppressed that sp., E. L. innocua. all strains, including was by TE/mL. Moreover, capacities determined using HO●, ABTS●+, DPPH● (HOSC, ABTS, RDSC, respectively) radicals. had TPC value 27.12 GAE/g, together with HOSC, ABTS values 1524.59, 56.38, 1.70 μmol TE/g, respectively. Our results suggest potential applications use functional to reduce microbial burdens oxidative stress-related health problems.

Language: Английский

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Biofilm Battle: New transformative tactics to tackle the bacterial biofilm infections

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 199, P. 107277 - 107277

Published: Jan. 5, 2025

Language: Английский

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Curcumin modulated gut microbiota and alleviated renal fibrosis in 5/6 nephrectomy-induced chronic kidney disease rats

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0314029 - e0314029

Published: Jan. 9, 2025

Increasing evidence suggests that dysbiosis of gut microbiota exacerbates chronic kidney disease (CKD) progression. Curcumin (CUR) has been reported to alleviate renal fibrosis in animal models CKD. However, the relationship between CUR and microbiome CKD remains unclear. This study aims investigate potential anti-renal effects from perspective. A 5/6 nephrectomy (5/6Nx) rat model was used explore therapeutic effect on fibrosis. Tight junction protein expression levels were measured assess intestinal barrier function. 16S rRNA sequencing employed evaluate changes composition, metabolomics utilized detect alterations plasma metabolites. The administration significantly ameliorated inhibited inflammation 5/6Nx rats. Additionally, markedly improved tight proteins local colon inflammation. also positively reconstructed microbiota, increasing abundance beneficial bacteria, such as Lachnospiraceae_NK4A136_group , Eubacterium_siraeum_group Muribaculaceae increased. Metabolomics revealed reduced uremic retention solutes elevated Vitamin D short-chain fatty acids (SCFAs). Spearman correlation analysis indicated genera enriched by correlated with SCFA negatively injury biomarkers. Mechanistically, we found inhibition LPS/TLR4/NF-κB TGF-β1/Smads pathway CUR-treated Our indicates modulate this modulation may contribute anti-fibrosis CUR.

Language: Английский

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Exploring the Potential of Chitosan–Phytochemical Composites in Preventing the Contamination of Antibiotic-Resistant Bacteria on Food Surfaces: A Review

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 455 - 455

Published: Jan. 21, 2025

The escalating presence of antibiotic-resistant bacteria (ARB) in food systems presents a pressing challenge, particularly preventing contamination and ensuring safety. Traditional sanitation methods, such as cooking chemical disinfectants, provide effective means to reduce ARB, yet there is growing need for additional preventive measures directly on surfaces. This review explores the potential chitosan–phytochemical composites (CPCs) surface coatings prevent initial by thereby offering novel complementary approach conventional safety practices. Chitosan, combined with active plant-derived metabolites (phytochemicals), forms notable antibacterial antioxidant properties that enhance its protective effects. We examine CPC synthesis methodologies, including modifications, free radical-induced grafting, enzyme-mediated techniques, which stability activity CPCs against ARB. Highlighting recent findings CPCs’ efficacy through minimum inhibitory concentrations (MIC) zones inhibition, this underscores ARB risks surfaces, seafood, meat, postharvest products. insights provided here aim encourage future strategies leveraging preventative treatment mitigate production processing environments.

Language: Английский

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Harnessing bioactive nanocurcumin and curcumin nanocomposites to combat microbial pathogens: a comprehensive review

Critical Reviews in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Feb. 20, 2025

The alarming rise in bacterial infections including those caused by multidrug-resistant pathogens has garnered the attention of scientific community, compelling them to explore as novel and effective alternatives combat these infections. Moreover, emerging viruses such Influenza A virus subtype H1N1 (A/H1N1), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Ebolavirus, recent coronavirus (SARS-CoV-2), etc. also a significant impact all over world. Therefore, management without any side effects is one most important challenges for community. Hence, development antimicrobial agents need hour. In this context, Curcuma longa, commonly known turmeric, been used traditional medicine centuries manage treat Its bioactive constituent, curcumin due its multifunctional bioactivities. Apart from properties, it possesses potent antioxidant anti-inflammatory activities. However, available reports suggest that low solubility, stability, biocompatibility limit use. on other hand, reported limitations associated with use can be resolved transforming into nano-form, specifically nanoparticles. Recent advancements have brought nanoparticles spotlight, showcasing superior properties broad spectrum applications. review, we mainly focused potential nanocurcumin, mechanisms underpinning their actions. aspects toxicity safety guidelines nano-based products discussed.

Language: Английский

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Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 2031 - 2031

Published: Oct. 14, 2022

One of the most significant classes mycotoxins, aflatoxins (AFTs), can cause a variety detrimental outcomes, including cancer, hepatitis, aberrant mutations, and reproductive issues. Among 21 identified AFTs, aflatoxin B1 (AFB1) is harmful to humans animals. The mechanisms AFB1-induced toxicity are connected generation excess reactive oxygen species (ROS), upregulation CYP450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, inflammatory response. Several signaling pathways, p53, PI3K/Akt/mTOR, Nrf2/ARE, NF-κB, NLRP3, MAPKs, Wnt/β-catenin have been shown contribute AFB1-mediated toxic effects in mammalian cells. Curcumin, natural product with multiple therapeutic activities (e.g., anti-inflammatory, antioxidant, anticancer, immunoregulation activities), could revise by targeting these pathways. Therefore, potential use curcumin against AFB1-related side underlying molecular summarized. This review, our opinion, advances knowledge, sparks larger discussions, drives additional improvements hazardous examination AFTs detoxifying application curcumin.

Language: Английский

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