Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(17), P. 2995 - 3012

Published: Aug. 14, 2023

Ferroptosis is increasingly being recognized as a key element in the pathogenesis of diverse diseases. Recent studies have highlighted intricate links between iron metabolism and neurodegenerative disorders. Emerging evidence suggests that homeostasis, oxidative stress, neuroinflammation all contribute to regulation both ferroptosis neuronal health. However, precise molecular mechanisms underlying involvement pathological processes neurodegeneration its impact on dysfunction remain incompletely understood. In our Review, we provide comprehensive analysis summary potential diseases, aiming elucidate disease progression neurodegeneration. Additionally, discuss therapeutic agents modulate with goal identifying novel drug molecules for treatment

Language: Английский

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Biosynthesis, Engineering, and Delivery of Selenoproteins

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 223 - 223

Published: Dec. 22, 2023

Selenocysteine (Sec) was discovered as the 21st genetically encoded amino acid. In nature, site-directed incorporation of Sec into proteins requires specialized biosynthesis and recoding machinery that evolved distinctly in bacteria compared to archaea eukaryotes. Many organisms, including higher plants most fungi, lack Sec-decoding trait. We review discovery its role redox enzymes are essential human health important targets disease. highlight recent genetic code expansion efforts engineer yeast. also methods produce selenoproteins with 21 or more acids approaches delivering recombinant mammalian cells new applications for synthetic biology.

Language: Английский

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GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells

Published: May 27, 2024

A pathway frequently altered in cancer is glutaminolysis where glutaminase (GA) catalyses the main step: deamidation of glutamine to form glutamate and ammonium. There are two types GA isozymes, named GLS GLS2, which differ considerably their expression patterns can even perform opposing roles cancer. correlates with tumor growth proliferation, while GLS2 may function as a context-dependent suppressor. However, both isoenzymes have been described essential molecules handling oxidant stress because involvement glutathione production. We reviewed literature highlight critical restrain ROS regulate cellular signaling metabolic due indirect antioxidant enzymes also by modulating reductive carboxylation ferroptosis. Blocking activity appears be potential strategy dual activate ferroptosis inhibit cell ROS-mediated mechanism.

Language: Английский

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The application of alkaloids in ferroptosis: A review

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117232 - 117232

Published: Aug. 3, 2024

Language: Английский

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Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Language: Английский

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