Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 403 - 403
Published: March 13, 2025
Background:
Carotenoids
are
bioactive
tetraterpenoid
C40
pigments
that
actively
synthesized
by
plants,
bacteria,
and
fungi.
Compounds
such
as
α-carotene,
β-carotene,
lycopene,
lutein,
astaxanthin,
β-cryptoxanthin,
fucoxanthin,
zeaxanthin
have
attracted
increasing
attention
for
their
antiaging
properties.
They
exhibit
antioxidant,
neuroprotective,
anti-inflammatory
properties,
contributing
to
the
prevention
treatment
of
age-related
diseases.
Objectives:
The
aim
this
study
was
comprehensively
analyze
pharmacological
potential
biological
mechanisms
carotenoids
associated
with
disorders
evaluate
application
in
nutraceuticals,
pharmaceuticals,
cosmeceuticals.
Methods:
A
systematic
review
studies
published
over
past
two
decades
conducted
using
databases
PubMed,
Scopus,
Web
Science.
selection
criteria
included
clinical,
silico,
vivo,
vitro
investigating
therapeutic
effects
carotenoids.
Results:
demonstrate
a
variety
health
benefits,
including
macular
degeneration,
cancer,
cognitive
decline,
metabolic
disorders,
skin
aging.
Their
role
nutraceuticals
is
well
supported
ability
modulate
oxidative
stress
inflammatory
pathways.
In
show
promising
results
formulations
targeting
neurodegenerative
diseases
disorders.
cosmeceuticals,
they
improve
protecting
it
against
UV
radiation
damage.
However,
bioavailability,
optimal
dosages,
toxicity,
interactions
other
compounds
remain
critical
factors
maximize
efficacy
still
require
careful
evaluation
scientists.
Conclusions:
interventions
applications
fields.
Further
research
needed
optimize
formulas,
confirm
long-term
safety
effectiveness,
especially
aging
population.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 5, 2022
Abstract
The
outbreak
of
COVID-19
has
become
a
global
crisis,
and
brought
severe
disruptions
to
societies
economies.
Until
now,
effective
therapeutics
against
are
in
high
demand.
Along
with
our
improved
understanding
the
structure,
function,
pathogenic
process
SARS-CoV-2,
many
small
molecules
potential
anti-COVID-19
effects
have
been
developed.
So
far,
several
antiviral
strategies
were
explored.
Besides
directly
inhibition
viral
proteins
such
as
RdRp
M
pro
,
interference
host
enzymes
including
ACE2
proteases,
blocking
relevant
immunoregulatory
pathways
represented
by
JAK/STAT,
BTK,
NF-κB,
NLRP3
pathways,
regarded
feasible
drug
development.
development
treat
achieved
strategies,
computer-aided
lead
compound
design
screening,
natural
product
discovery,
repurposing,
combination
therapy.
Several
representative
remdesivir
paxlovid
proved
or
authorized
emergency
use
countries.
And
candidates
entered
clinical-trial
stage.
Nevertheless,
due
epidemiological
features
variability
issues
it
is
necessary
continue
exploring
novel
COVID-19.
This
review
discusses
current
findings
for
treatment.
Moreover,
their
detailed
mechanism
action,
chemical
structures,
preclinical
clinical
efficacies
discussed.
Food & Function,
Journal Year:
2023,
Volume and Issue:
14(17), P. 7799 - 7824
Published: Jan. 1, 2023
Humans
are
unique
indiscriminate
carotenoid
accumulators,
so
the
role
of
carotenoids
as
dietary
antioxidants
with
or
without
enzymatic
conversion
attracts
renewed
attention
from
standpoint
health
promotion
and
disease
prevention.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2600 - 2600
Published: Feb. 23, 2024
Free
radicals
(FRs)
are
unstable
molecules
that
cause
reactive
stress
(RS),
an
imbalance
between
oxygen
and
nitrogen
species
in
the
body
its
ability
to
neutralize
them.
These
generated
by
both
internal
external
factors
can
damage
cellular
lipids,
proteins,
DNA.
Antioxidants
prevent
or
slow
down
oxidation
process
interrupting
transfer
of
electrons
substances
agents.
This
is
particularly
important
at
level
because
reactions
lead
formation
FR
contribute
various
diseases.
As
we
age,
RS
accumulates
leads
organ
dysfunction
age-related
disorders.
Polyphenols;
vitamins
A,
C,
E;
selenoproteins
possess
antioxidant
properties
may
have
a
role
preventing
treating
certain
human
diseases
associated
with
RS.
In
this
review,
explore
current
evidence
on
potential
benefits
dietary
supplementation
investigate
intricate
connection
SIRT1,
crucial
regulator
aging
longevity;
transcription
factor
NRF2;
polyphenols,
vitamins,
selenium.
Finally,
discuss
positive
effects
molecules,
such
as
reducing
RS,
their
slowing
several
Molecules,
Journal Year:
2024,
Volume and Issue:
29(3), P. 728 - 728
Published: Feb. 4, 2024
The
elevated
occurrence
of
non-melanoma
skin
cancer
(NMSC)
and
the
adverse
effects
associated
with
available
treatments
adversely
impact
quality
life
in
multiple
dimensions.
In
connection
this,
there
is
a
necessity
for
alternative
approaches
characterized
by
increased
tolerance
lower
side
effects.
Natural
compounds
could
be
employed
due
to
their
safety
profile
effectiveness
inflammatory
neoplastic
diseases.
These
anti-cancer
drugs
are
often
derived
from
natural
sources
such
as
marine,
zoonotic,
botanical
origins.
should
exhibit
anti-carcinogenic
actions
through
various
pathways,
influencing
apoptosis
potentiation,
cell
proliferation
inhibition,
metastasis
suppression.
This
review
provides
an
overview
used
chemotherapies,
chemoprevention,
promotion
regeneration,
including
polyphenolic
compounds,
flavonoids,
vitamins,
alkaloids,
terpenoids,
isothiocyanates,
cannabinoids,
carotenoids,
ceramides.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(8), P. 1451 - 1451
Published: July 26, 2022
The
antioxidant
system
of
the
human
body
plays
a
crucial
role
in
maintaining
redox
homeostasis
and
has
an
important
protective
function.
Carotenoids
have
pronounced
properties
neutralization
free
radicals.
In
skin,
carotenoids
high
concentration
stratum
corneum
(SC)-the
horny
outermost
layer
epidermis,
where
they
accumulate
within
lipid
lamellae.
Resonance
Raman
spectroscopy
diffuse
reflectance
are
optical
methods
that
used
to
non-invasively
determine
carotenoid
SC
vivo.
It
was
shown
by
electron
paramagnetic
resonance
support
entire
status
vivo
neutralizing
radicals
thus,
counteracting
development
oxidative
stress.
This
review
is
devoted
assembling
kinetics
using
non-invasive
spectroscopic
methods.
Factors
contributing
changes
their
influence
on
summarized.
effect
chemotherapy
cancer
patients
presented.
A
potential
antioxidant-based
pathomechanism
chemotherapy-induced
hand-foot
syndrome
method
reduce
its
frequency
severity
discussed.
Foods,
Journal Year:
2022,
Volume and Issue:
11(18), P. 2796 - 2796
Published: Sept. 10, 2022
The
addition
of
natural
components
with
functional
properties
in
novel
food
formulations
confers
one
the
main
challenges
that
modern
industry
is
called
to
face.
New
EU
directives
and
global
turn
circular
economy
models
are
also
pressing
agro-industrial
sector
adopt
cradle-to-cradle
approaches
for
their
by-products
waste
streams.
This
review
aims
present
concept
“sustainable
compounds”,
emphasizing
on
some
bioactive
compounds
could
be
recovered
or
biotechnologically
produced
from
renewable
resources.
Herein,
view
efficient
“greener”
production
extraction,
emerging
technologies,
together
possible
advantages
drawbacks,
presented
discussed.
Μodern
examples
novel,
clean
label
products
composed
sustainable
summarized.
Finally,
action
plans
towards
establishment
systems
suggested.
