Skin Protection by Carotenoid Pigments

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1431 - 1431

Published: Jan. 24, 2024

Sunlight, despite its benefits, can pose a threat to the skin, which is natural protective barrier. Phototoxicity caused by overexposure, especially ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, photosynthetic pigments, protect against effects radiation, acting not only as photoprotectors like filters but antioxidant anti-inflammatory remedies, alleviating photodamage skin. Plant-based formulations are gaining popularity an attractive alternative synthetic filters. Over past 20 years, large number studies have been published assess photoprotective products, primarily through their antioxidant, antimutagenic, anti-immunosuppressive activities. This review selects most important data on efficacy selected carotenoid representatives from vivo animal models humans, well vitro experiments performed fibroblast keratinocyte cell lines. Recent research carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, micelles reviewed. The focus was collecting those nanomaterials that serve improve bioavailability stability antioxidants activity.

Language: Английский

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Vibrational Spectroscopy as a Tool for Bioanalytical and Biomonitoring Studies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6947 - 6947

Published: April 8, 2023

The review briefly describes various types of infrared (IR) and Raman spectroscopy methods. At the beginning review, basic concepts biological methods environmental monitoring, namely bioanalytical biomonitoring methods, are considered. main part principles vibration microspectrophotometry, in particular IR spectroscopy, mid- near-IR microspectroscopy, resonance Surface-enhanced microscopy. Examples use for study samples, especially context given. Based on described results, authors conclude that spectroscopy-based most convenient studies, relevance monitoring will increase with time.

Language: Английский

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Bioactivity and Bioavailability of Carotenoids Applied in Human Health: Technological Advances and Innovation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7603 - 7603

Published: July 11, 2024

This article presents a groundbreaking perspective on carotenoids, focusing their innovative applications and transformative potential in human health medicine. Research jointly delves deeper into the bioactivity bioavailability of revealing therapeutic uses technological advances that have to revolutionize medical treatments. We explore pioneering which carotenoids are used treat chronic diseases such as cancer, cardiovascular disease, age-related macular degeneration, offering novel protective mechanisms benefits. Our study also shows cutting-edge innovations carotenoid extraction bioavailability, including development supramolecular carriers advanced nanotechnology, dramatically improve absorption efficacy these compounds. These not only ensure consistent quality but tailor therapies each patient's needs, paving way for personalized By integrating latest scientific discoveries techniques, this research provides prospective clinical establishing new benchmark future studies field. findings underscore importance optimizing extraction, administration, bioactivity, methods develop more effective, targeted, treatments, thus visionary insight modern practices.

Language: Английский

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An alternative source of medicines: pharmaceutical utilization of animal-derived metabolites

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Throughout history, various human civilizations have used raw materials obtained from the body parts, metabolic byproducts, or non-animal components of animals as medical resources for treatment numerous diseases and relief symptoms. Protein structures, including hormones enzymes, well animal-derived metabolites polysaccharides, lipids, vitamins, been development drugs. These chemicals include widely substances heparin, melatonin, collagen, glucosamine, chondroitin, bile acids, coenzyme Q10. Additionally, they such snake, spider, amphibian poisons, which are now undergoing therapeutic development. This review presents examples pharmaceutical that being drugs potential in drug research. Detailed descriptions chemical original sources effects these included. In general, production method was previously carried out by using animal organisms has replaced utilization recombinant technologies. The use a resource process is expected to remain an interesting topic further research this area expected. Nevertheless, it essential not disregard suggestions against utilizing production, particularly cases where alternative accessible.

Language: Английский

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Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 30, 2023

Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones, represents a major concern human health. The present review comprehensively examines various categories endocrine within glands, encompassing glucocorticoids, mineralocorticoids, and androgens. Additionally, comprehensive account hormone disorders, including insufficiency, Cushing’s syndrome, tumors, is presented, with particular emphasis on their intricate association oxidative stress. also delves into an examination nutritional antioxidants, namely vitamin C, E, carotenoids, selenium, zinc, polyphenols, coenzyme Q10, probiotics, elucidates role mitigating adverse effects stress arising imbalances levels. In conclusion, harnessing power antioxidants has potential to help caused by imbalance hormones. This could lead new research therapeutic interventions.

Language: Английский

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Current Insights on the Photoprotective Mechanism of the Macular Carotenoids, Lutein and Zeaxanthin: Safety, Efficacy and Bio-Delivery

Journal of the American Nutrition Association, Journal Year: 2024, Volume and Issue: 43(6), P. 505 - 518

Published: Feb. 23, 2024

Ocular health has emerged as one of the major issues global concern with a decline in quality life an aging population, particular and rise number associated morbidities mortalities. One chief reasons for vision impairment is oxidative damage inflicted to photoreceptors rods cone cells by blue light well UV radiation. The scenario been aggravated unprecedented screen-time during COVID post-COVID era. Lutein Zeaxanthin are oxygenated carotenoids proven roles augmentation ocular largely virtue their antioxidant properties protective effects against photobleaching retinal pigments, age-linked macular degeneration, cataract, retinitis pigmentosa. These molecules characterized characteristic yellow-orange colored pigmentation found significant amounts vegetables such corn, spinach, broccoli, carrots fish eggs. Unique structural signatures including tetraterpenoid skeleton extensive conjugation presence hydroxyl groups at end rings have made these evolutionarily adapted localize membrane photoreceptor prevent free radical induced peroxidation. Apart from benefits imparted health, lutein zeaxanthin also known improve cognitive function, cardiovascular physiology, arrest development malignancy. Although abundant many natural sources, bioavailability compounds low owing long aliphatic backbones. Under circumstances, there concerted effort develop vegetable oil-based carriers lipid nano-emulsions therapeutic administration carotenoids. This review presents comprehensive update potential along challenges achieving optimized delivery tool maximizing effectiveness inside body.

Language: Английский

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Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances, Possibilities, Prospects, and Translation into In Vivo Human Studies

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2272 - 2272

Published: Sept. 3, 2023

Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic (FCIs) topically applied formulations or contaminants (substances) in skin is great importance for understanding their interaction with targets, treatment efficacy, risk assessment—a challenging task dermatology, cosmetology, pharmacy. Non-invasive methods qualitative quantitative visualization substances vivo are favored limited to optical imaging spectroscopic such as fluorescence/reflectance confocal laser scanning microscopy (CLSM); two-photon tomography (2PT) combined autofluorescence (2PT-AF), fluorescence lifetime (2PT-FLIM), second-harmonic generation (SHG), coherent anti-Stokes Raman scattering (CARS), reflectance (2PT-RCM); three-photon (3PT); micro-spectroscopy (CRM); surface-enhanced (SERS) micro-spectroscopy; stimulated (SRS) microscopy; coherence (OCT). This review summarizes state art use CLSM, 2PT, 3PT, CRM, SERS, SRS, OCT study non-invasively (302 references). The advantages, limitations, possibilities, prospects reviewed comprehensively discussed. ex studies discussed potentially translatable into measurements. requirements properties determine by certain highlighted.

Language: Английский

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Dietary Antioxidants May Support Cosmetic Treatment in Patients with Rosacea

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 381 - 381

Published: March 21, 2024

Rosacea is a chronic skin disease that significantly reduces the quality of life (QoL) patients. The aim this study was to assess whether dietary antioxidants can support effect cosmetic treatment in improving QoL patients with rosacea. Basic data about participants (N = 160) were collected using self-reported survey. assessed standardized Dermatology Life Quality Index (DLQI) questionnaire. An interventional performed cavitation peeling and sonophoresis commercial capillary repair serum. registered as clinical trial (NCT06271135). To antioxidant diet quality, for first time, new index (DAQI) developed, which consisted 12 items: total capacity, polyphenols, phytosterols, lignans, vitamin C, E, β-carotene, zinc, iron, copper, manganese selenium. It found highest tertiles DAQI diminished odds 40–45% moderate, large extremely rosacea on 8–11% occurrence symptoms compared lowest tertile. This showed has negative impact QoL, but comprehensive approach treatment, including antioxidants, improve

Language: Английский

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Diagnostic Accuracy of Raman Spectroscopy Integrated With Polarized Light Microscopy for Calcium Pyrophosphate–Associated Arthritis

Arthritis Care & Research, Journal Year: 2024, Volume and Issue: 76(9), P. 1333 - 1341

Published: April 16, 2024

We studied the performance of integrated Raman polarized light microscopy (iRPolM) for identification calcium pyrophosphate (CPP)-associated arthritis (CPPD).

Language: Английский

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A Narrative Review of Factors Associated with Skin Carotenoid Levels

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2156 - 2156

Published: April 30, 2023

Despite consistent evidence that greater consumption of fruits and vegetables (FV) is associated with significant reductions in chronic disease morbidity mortality, the majority adults United States consume less than amounts recommended by public health agencies. As such, there a critical need to design implement effective programs policies facilitate increases FV for prevention these diseases. To accomplish this, an accurate, inexpensive, convenient method estimating dietary intake required. A promising quantifying via proxy has gained interest recent years measurement skin carotenoid levels spectroscopy-based devices. However, exist certain non-dietary factors may affect independently carotenoids. In order validate ability this accurately estimate among diverse demographics, must be identified taken into consideration. Therefore, narrative review seeks summarize available research on levels, determine current gaps knowledge, provide guidance future efforts seeking spectroscopy-measured as means various populations.

Language: Английский

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