Treatment of animals with fatty liver disease using a drug based on the seeds of Silybum marianum DOI Creative Commons
Vasyl Vlizlo, O. I. Prystupa, L. G. Slivinskа

et al.

Regulatory Mechanisms in Biosystems, Journal Year: 2023, Volume and Issue: 14(3), P. 424 - 431

Published: Aug. 23, 2023

Medicinal plants are a source of various therapeutic preparations. Therefore, the aim our work was to prepare liposomal drug from extract seeds Silybum marianum (L.) Gaertn., adding tocopherol acetate, lecithin, squalene, and Tween 80. The used on laboratory animals (rats) intramuscularly measure efficacy treatment experimentally modeled toxic fatty liver disease. infiltration in rats caused by tetrachloromethane (ССl4). based S. studied 25 which pathology had been 50% oil solution ССl4, administered dose 5 mL per kg body weight. diseased were divided into five groups, each consisting animals. Animals four experimental groups – first, second, third, fourth - received doses 0.05, 0.25, 0.50, 1.50 mL/kg weight three times every two days, respectively. At same time, control three-time intramuscular injection physiological 0.5 Treatment with disease injections normalized general condition, significantly improved functions structure liver. Biochemical studies blood serum sick after revealed increase albumin content, may suggest reduction protein-synthesizing function normalization bile-forming bile-excreting liver, also elimination cholestasis evidenced reduced contents bile acids total bilirubin increased cholesterol rats. After treating created drug, we saw decrease activity liver-indicator enzymes (aspartate aminotransferase, alanine gamma-glutamyltransferase, glutamate dehydrogenase) serum, is sign recovery hepatocytes cytolysis. Histological treated confirmed positive effect organ’s structure. In future studies, plan test this combination agents agricultural domestic pathologies.

Language: Английский

Reactive oxygen species and ovarian diseases: Antioxidant strategies DOI Creative Commons

Junzhi Liang,

Yingzhuo Gao,

Ziyi Feng

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102659 - 102659

Published: March 7, 2023

Reactive oxygen species (ROS) are mainly produced in mitochondria and involved various physiological activities of the ovary through signaling critical for regulating ovarian cycle. Notably, imbalance between ROS generation antioxidant defense system contributes to development diseases. These contradictory effects have implications potential strategies that aim scavenge excessive ROS. However, much remains be learned about how causes diseases application therapy Here, we review mechanisms maintenance homeostasis its associated effects. Additionally, highlighted pathological treatment.

Language: Английский

Citations

75
Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity DOI Creative Commons
Haichao Wang,

Aisima Ainiwaer,

Yaxiang Song

et al.

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: Jan. 9, 2023

Abstract Background Chronic kidney disease (CKD) is a severe public health problem associated with disordered gut microbiome. However, the functional alterations of microbiota and their cross talk metabolism pathways based on severity remain unclear. Results We performed metagenomics untargeted metabolomics in cohort 68 patients CKD differing severities 20 healthy controls to characterize complex interplay between microbiome fecal serum metabolites during progression. identified 26 microbial species that significantly changed CKD; 18 as progressed, eight only specific group. These distinct changes were accompanied by arginine proline, arachidonic acid, glutathione ubiquinone other terpenoid-quinone biosynthesis Further metabolomic analyses revealed distributions toxic pro-oxidant from these four essential metabolic varied feces progressed. Furthermore, we observed co-occurrence severity-related bacteria characterized pathways. Notably, Ruminococcus bromii , hydroquinone, creatinine main contributors integrated network, indicating key roles Moreover, noninvasive model including R. L-cystine, 12-keto-tetrahydro-LTB4 levels classified (area under curve [AUC]: > 0.9) had better performance than level for mild ( AUC : 0.972 vs. 0.896). Conclusions Perturbed may contribute unbalanced host, accelerating progression, which be an early diagnostic therapeutic target CKD.

Language: Английский

Citations

61
Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies DOI Open Access
M. A. Darenskaya, С. И. Колесников, Н. В. Семенова

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378

Published: Aug. 3, 2023

Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention

Language: Английский

Citations

47
Role of Vitamin-E as a Vital Nutrient in Health and Diseases DOI
Ghizal Fatima,

Andrej Džupina,

Abbas Ali Mahdi

et al.

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

2
Oxidative Stress: What Is It? Can It Be Measured? Where Is It Located? Can It Be Good or Bad? Can It Be Prevented? Can It Be Cured? DOI Creative Commons
Angelo Azzi

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1431 - 1431

Published: July 23, 2022

The meaning, the appropriate usage and misusage of terms oxidative stress, eustress, distress have been evaluated. It has realized that stress damage are often used inappropriately as synonyms. term eustress (intended good stress) is unsuitable to indicate signaling by reactive molecular an event can be finalistically considered either or bad, depending on circumstances. so defined but not stress. What measured in fact damage. Damaging oxidations oxidant events (good bad) present, also simultaneously, different multiple location a cell, tissue body measure fluids specimen only sum non-separatable events, sometimes opposite sign. There no officially approved therapy prevent cure

Language: Английский

Citations

47
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases DOI Creative Commons
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1462 - 1462

Published: Nov. 28, 2024

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes

Language: Английский

Citations

10
Natural cellulosic biofunctional textiles from onion (Allium cepa L.) skin extracts: A sustainable strategy for skin protection DOI
Desirée Bartolini,

Letizia Pallottelli,

Damiano Sgargetta

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 212, P. 118295 - 118295

Published: March 2, 2024

Language: Английский

Citations

9
The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018 DOI Creative Commons
Juan Wu, Yingdong Han, Menghui Yao

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 23, 2025

Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate associations Balance Score (OBS) with both general population This study included 37,317 adults (52% female) from National Health Nutrition Examination Survey (2001-2018). OBS was calculated based antioxidant pro-oxidant exposures categorized into quartiles. Survey-weighted Cox proportional hazards models were used estimate hazard ratios for risks. Restricted cubic spline analyses performed examine potential non-linear relationships. Stratified conducted further refine findings. During mean follow-up 9.1 years, 5,092 deaths occurred. Compared lowest quartile, highest quartile total associated lower all-cause (HR 0.68) 0.55). Among survivors, similar observed 0.66). Component analysis revealed consistent protective effects 0.60 mortality), while higher showed varying across causes. Higher risks, cancer-related mortality, effects, varied by

Language: Английский

Citations

1
Effect of oral nutritional supplements on inflammation and oxidative stress in hemodialysis patients: a meta-analysis DOI
Tao Shen, Linlin Jiang, Qunjuan Zhang

et al.

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

1
Beneficial and adverse effects of vitamin E on the kidney DOI Creative Commons
Aldona Baltušnikienė,

Inga Stanevičienė,

Eugène Jansen

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: March 15, 2023

This article reviews the beneficial and adverse effects of high-dose vitamin E supplementation on status renal function in human rodent studies. The high doses E, which can cause effects, were compared to upper limits toxicity (UL) as established by various authorities worldwide. In recent mice studies with higher several biomarkers tissue inflammation found be significantly elevated. these biomarker studies, severity increased levels are discussed together need re-evaluate ULs, given toxic kidney emphasizing oxidative stress inflammation. controversy literature about is mainly caused dose-effects relations that do not give a clear view, neither nor animals addition, more rodents new insights into possible mechanisms. this review, shown an advice for health.

Language: Английский

Citations

17