The involvement of ROS-regulated programmed cell death in hepatocellular carcinoma

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104361 - 104361

Published: April 16, 2024

Language: Английский

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Role of reactive oxygen species in myelodysplastic syndromes

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 14, 2024

Abstract Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) triggers cellular apoptosis. Mounting literature supports the view that are closely interwoven with pathogenesis cluster diseases, particularly those involving cell proliferation differentiation, such myelodysplastic syndromes (MDS) chronic/acute myeloid leukemia (CML/AML). OS caused by excessive at physiological levels is likely to affect functions hematopoietic stem cells, growth self-renewal, which may contribute defective hematopoiesis. We review herein eminent hematological niche profound influence on progress MDS. highlight targeting practical reliable tactic for MDS therapy. Graphical

Language: Английский

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Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 898 - 898

Published: July 25, 2024

Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing crucial roles in physiological processes oncogenesis. Excessive ROS levels can induce DNA damage, leading to cancer, disrupt antioxidant defenses, contributing diseases like diabetes cardiovascular disorders. Antioxidant mechanisms include enzymes small molecules that mitigate damage. However, cancer cells often exploit conditions evade apoptosis promote tumor growth. therapy has shown mixed results, timing cancer-type influencing outcomes. Multifunctional drugs targeting multiple pathways offer a promising approach, reducing side effects improving efficacy. Recent research focuses on sulfur-nitrogen heterocyclic derivatives for their dual anticancer properties, potentially enhancing therapeutic efficacy oncology. The newly synthesized compounds do not demonstrate both properties simultaneously. Heterocyclic rings typically combined phenyl groups, where hydroxy substitutions enhance activity. On the other hand, electron-withdrawing substituents, particularly at p-position ring, tend

Language: Английский

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Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 149, P. 107483 - 107483

Published: May 21, 2024

Language: Английский

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Untargeted Metabolomics Reveals the Metabolic Characteristics and Biomarkers of Antioxidant Properties of Gardeniae Fructus from Different Geographical Origins in China

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 38 - 38

Published: Jan. 10, 2025

Background/Objectives: Gardeniae Fructus (GF) has been widely used as both food and medicinal purposes for thousands of years, but their antioxidant properties potential metabolite biomarkers remain unclear. Methods: The this study were to examine activities 21 GF varieties from different geographical origins in China identify using an untargeted LC-MS-based metabolomics approach. Results: results demonstrate that had the ability trace GF. We found varied with GF, which was dependent on chemical compositions. key categories obtained primary contributors activity, including prenol lipids, flavonoids, coumarins derivatives, well steroids steroid derivatives. In addition, adouetine Y, coagulin R 3-glucoside epicatechin identified activity Conclusions: Therefore, our sheds light metabolic characteristics contributing selection cultivation a high variety.

Language: Английский

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Exploring the Therapeutic Potential of Artemisia and Salvia Genera in Cancer, Diabetes, and Cardiovascular Diseases: A Short Review of Clinical Evidence

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 1028 - 1028

Published: Feb. 6, 2025

Metabolic syndrome, a cluster of metabolic disorders comprising dyslipidemia, insulin resistance, elevated blood pressure, and abdominal obesity, is silent epidemic that may lead to outcomes such as cardiovascular disease, diabetes, cancer. Due the increase in prevalence these pathologies, search for better treatments more efficient drugs imperative. Species Artemisia Salvia genera are excellent examples noteworthy sources bioactive products with health applications, their therapeutic properties being well known both popular medicine scientific community. There reports plant extracts or compounds from species belonging either genera, which were able combat cancer, pathologies. For instance, dihydroartemisinin (analog artemisin extracted annua L.) can reduce tumor markers p53 Ki-67 expression levels, leading reduction proliferation. officinalis L. has antihyperglycemic lipid profile-improving effects since it decreases total cholesterol, glycosylated hemoglobin, fasting glucose, low-density lipoprotein triglyceride levels while increasing high-density cholesterol levels. Clinical trials using mixtures (dried powdered plants extracts) medicinal recurrent published works, contrast scarce clinical trial studies isolated compounds. miltiorrhiza Bunge. was by far most targeted analyzed here. Regarding concerning Artemisia, there aiming see its effect on but about cancer advanced. This review aims give critical summary interesting promising results trials. The abundance limited statistically significant evidence hinders progress therapy. situation demands greater rigor community, researchers, regulatory agencies, editors, reviewers conducting publishing studies.

Language: Английский

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Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264

Published: Feb. 25, 2025

Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.

Language: Английский

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Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery

Plants, Journal Year: 2025, Volume and Issue: 14(6), P. 951 - 951

Published: March 18, 2025

Melanoma, a type of skin cancer originating from melanocytes, represents significant public health concern according to the World Health Organization. It is one most commonly diagnosed cancers worldwide, particularly affecting populations in Europe and North America, with an increasing incidence Asia. The rise emphasizes need for diversified treatment approaches. Conventional treatments melanoma, including immunotherapy, chemotherapy, targeted therapies like FDA-approved Opdivo Relatlimab, often come severe side effects high relapse rates. Consequently, natural products have gained considerable attention their potential enhance therapeutic outcomes reduce adverse effects. This systematic review evaluates anti-cancer properties against examining 52 studies PubMed Google Scholar. Our analysis focuses on antioxidant, anti-angiogenesis, anti-metastatic, apoptosis-inducing activities these compounds, also discussing regulatory factors involved. findings advocate intensified research into as complementary agents melanoma treatment, aiming improve efficacy patient quality life. Further vitro, vivo, clinical trials are essential validate effectiveness integrate them standard care protocols.

Language: Английский

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Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6092 - 6092

Published: March 23, 2023

Cancer is an escalating global issue, with 19.3 million new cases and 9.9 deaths in 2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a significant role determining risk. Nutrients food bioactives influence specific signaling pathways the body. Recently, there have been advances prevention research through nutrigenomics or effects of dietary components on genome. Google Scholar, PubMed, Scopus databases were used search for peer-reviewed articles between 2017 2023. Criteria vitamins, minerals, tumors, cancer, genes, inflammation, pathways, nutrigenomics. Among total 1857 available, highest relevant 90 that specifically discussed genes cell lines human patients selected reviewed. Food sources rich antioxidant micronutrients, which activating regulating involved pathogenesis therapy by enzymes such as mitogen-activated protein kinase (MAPK), C (PKC), phosphatidylinositol 3-kinase (PI3K). The micronutrients regulation β-catenin (WNT/β-catenin) including mutations Kras epidermal growth factor receptor (EGFR) alongside inhibition NF-kB pathway. most common mechanism these their antioxidative, anti-inflammation, anti-apoptosis effects. This review discusses how essential beneficial developing treatment approaches.

Language: Английский

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Multifactorial Diseases of the Heart, Kidneys, Lungs, and Liver and Incident Cancer: Epidemiology and Shared Mechanisms

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 729 - 729

Published: Jan. 25, 2023

Within the aging population, frequency of cancer is increasing dramatically. In addition, multiple genetic and environmental factors lead to common multifactorial diseases, including cardiovascular disease, chronic kidney obstructive pulmonary metabolic-associated fatty liver disease. recent years, there has been a growing awareness connection between as well how one can affect other, resulting in vicious cycle. Although exact mechanistic explanations behind this remain be fully explored, some progress made uncovering pathologic mechanisms. review, we focus on nature link conditions, specific shared mechanisms, which may represent either preventive or therapeutic targets. Rather than organ-specific interactions, herein mechanisms among explain increased risk. More research subject will highlight significance developing new drugs that target systems rather just

Language: Английский

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