Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases DOI Creative Commons
Juan Gao, Jiaxin Song,

Yuwei Yan

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(9)

Published: Sept. 6, 2023

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function cardiopulmonary fitness. mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process essential responding to exercise-stress mediating exercise-protective effects. Thus, review summarizes the biogenesis miRNAs, mechanism miRNA action, specifically miRNAs involved cardio-protection used as therapeutic targets for treating

Language: Английский

Aged Gut Microbiome Induces Metabolic Impairment and Hallmarks of Vascular and Intestinal Aging in Young Mice DOI Creative Commons
Chak Kwong Cheng, Lianwei Ye, Yuanyuan Zuo

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1250 - 1250

Published: Oct. 17, 2024

Aging, an independent risk factor for cardiometabolic diseases, refers to a progressive deterioration in physiological function, characterized by 12 established hallmarks. Vascular aging is driven endothelial dysfunction, telomere oxidative stress, and vascular inflammation. This study investigated whether aged gut microbiome promotes metabolic impairment. Fecal transfer (FMT) was conducted from (>75 weeks old) young C57BL/6 mice (8 6 weeks. Wire myography used evaluate function aortas mesenteric arteries. ROS levels were measured dihydroethidium (DHE) staining lucigenin-enhanced chemiluminescence. intestinal terms of relative length, telomerase reverse transcriptase expression activity, measured. Systemic inflammation, endotoxemia integrity assessed. Gut profiles studied 16S rRNA sequencing. Some middle-aged (40-42 subjected chronic metformin treatment exercise training 4 their anti-aging benefits. Six-week FMT impaired glucose homeostasis caused dysfunction arteries mice. triggered inflammation along with declined activity shorter length aortas. Additionally, integrity, AMPK inactivation intestines, potentially attributed the altered microbial profiles. Metformin moderate improved activation mouse intestines. Our data highlight as mechanism that accelerates aging, suggesting gut-vascular connection potential intervention target against cardiovascular complications.

Language: Английский

Citations

2
Exercise as a therapeutic approach to alleviate diabetic kidney disease: mechanisms, clinical evidence and potential exercise prescriptions DOI Creative Commons

Rao Fan,

Jianda Kong, Jiahao Zhang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 25, 2024

Diabetic kidney disease (DKD) is a global and severe complication that imposes significant burden on individual health, families, society. Currently, the main treatment approaches for DKD include medication, blood glucose control, protein-restricted diet, pressure management, all of which have certain limitations. Exercise, as non-pharmacological intervention, has attracted increasing attention. This review introduces mechanisms clinical evidence exercise DKD, proposes potential prescriptions. Exercise can improve stability related to renin-angiotensin-aldosterone system (RAAS), reduce renal oxidative stress inflammation, enhance crosstalk between muscle kidneys, endothelial cell function. These contribute comprehensive improvement DKD. Compared traditional methods, several advantages, including safety, effectiveness, no side effects. It be used an adjunct therapy management. Despite evident benefits in there still lack large-scale, long-term randomized controlled trials provide more develop guidelines Healthcare professionals should actively encourage patients personalized plans based circumstances.

Language: Английский

Citations

2
Vascular endothelium: The interface for multiplex signal transduction DOI
Chak Kwong Cheng, Yu Huang

Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: 195, P. 97 - 102

Published: Aug. 13, 2024

Language: Английский

Citations

1
MicroRNA-181b-5p/HEY2 axis is involved in the progress of deep venous thrombosis via mediating vascular endothelial injury DOI Creative Commons
Dawei Zhang, Cheng Cheng, Meiying Yang

et al.

Hematology, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 4, 2024

Objectives: Deep-venous thrombosis (DVT) refers to abnormal blood clotting in the deep vein cavity, and post-thrombotic syndrome (PTS) is most frequent complication. The study explored impact of microRNA 181b-5p on DVT progression based human umbilical endothelial cells (HUVECs).

Language: Английский

Citations

1
Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases DOI Creative Commons
Juan Gao, Jiaxin Song,

Yuwei Yan

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(9)

Published: Sept. 6, 2023

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function cardiopulmonary fitness. mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process essential responding to exercise-stress mediating exercise-protective effects. Thus, review summarizes the biogenesis miRNAs, mechanism miRNA action, specifically miRNAs involved cardio-protection used as therapeutic targets for treating

Language: Английский

Citations

2