Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling DOI Creative Commons
Junichi Fujii, Tsukasa Osaki

Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 814 - 814

Published: Jan. 13, 2023

When the expression of NOS2 in M1-polarized macrophages is induced, huge amounts nitric oxide (•NO) are produced from arginine and molecular oxygen as substrates. While anti-microbial action primary function M1 macrophages, excessive activation may result inflammation being aggravated. The reaction •NO with superoxide produces peroxynitrite, which highly toxic to cells. Alternatively, however, this eliminates radial electrons occasionally alleviate subsequent radical-mediated damage. Reactions lipid radicals terminates radical chain peroxidation, leads suppression ferroptosis. involved metabolic remodeling macrophages. Enzymes tricarboxylic acid (TCA) cycle, notably aconitase 2, well respiratory enzymes, preferential targets derivatives. Ornithine, an alternate compound instead citrulline •NO, recruited synthesize polyamines. Itaconate, remodeled TCA polyamines defense systems against overresponses a feedback manner. Herein, we overview protective aspects species autoregulatory that enabled by M9-polarized

Language: Английский

A Review of Immunological Evaluation of Patients with Recurrent Spontaneous Abortion (RSA) DOI Open Access
Mihaela Andreescu, Alina Tănase,

Bogdan Andreescu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 785 - 785

Published: Jan. 17, 2025

In approximately half of the recurrent spontaneous abortion (RSA) cases, underlying cause is unknown. However, most unexplained miscarriages are thought to be linked immune dysfunction. This review summarizes current evidence regarding immunological evaluations patients with RSA, potential implications for clinical research. The system plays a crucial role in successful outcome pregnancy, as it tolerates semi-allogeneic fetus while offering protection both mother and from pathogens. maternal-fetal interface place where crosstalk between various cells such macrophages, dendritic cells, natural killer (NK) T takes place. An adequate balance required these pregnancy progress. dysregulation players witnessed. For example, NK not increased but also undergo change their activity, manifested cytotoxic decidual NK. Similarly, regulatory which fostering tolerant environment, decreased RSA women. imbalances T-helper (Th1, Th2, Th17) cell subsets have been implicated RSA. Furthermore, imbalance pro-inflammatory M1 anti-inflammatory M2 macrophage phenotypes has documented, studies indicating predominance macrophages patients. Targeting therapies immunoglobulin administration, TNF inhibitors, anticoagulants may improve outcomes women

Language: Английский

Citations

3
New Horizons of Macrophage Immunomodulation in the Healing of Diabetic Foot Ulcers DOI Creative Commons
Ching‐Wen Lin, Chien‐Min Hung, W.H. Chen

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(10), P. 2065 - 2065

Published: Sept. 27, 2022

Diabetic foot ulcers (DFUs) are one of the most costly and troublesome complications diabetes mellitus. The wound chronicity DFUs remains main challenge in current future treatment this condition. Persistent inflammation results chronic wounds characterized by dysregulation immune cells, such as M1 macrophages, impairs polarization M2 macrophages subsequent healing process DFUs. interactive regulation during DFU is critical seems manageable. This review details how cytokines signalling pathways co-ordinately regulated to control functions normal repair. defective M1-to-M2 transition, which halts whole wound-healing machinery. Many pre-clinical clinical innovative approaches, including application topical insulin, CCL chemokines, micro RNAs, stem stem-cell-derived exosomes, skin substitutes, antioxidants, recent Phase III-approved ON101 cream, have been shown modulate activity ON101, newest clinically approved product setting, designed specifically down-regulate further microenvironment favour emergence expansion. Finally, evolution macrophage modulation therapies techniques will improve effectiveness diverse

Language: Английский

Citations

48
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment DOI Creative Commons
Michael G. Monaghan, Rajiv Borah,

Charlotte Thomsen

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115120 - 115120

Published: Oct. 25, 2023

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading tissue regeneration restoration barrier function skin. In contrast, in dysregulation these leads chronic, non-healing wounds. particular, unresolved inflammation DFU microenvironment has been identified as key facet chronic hyperglyceamic patients, DFUs fail beyond inflammatory phase towards resolution. Thus, control over modulation response is promising therapeutic avenue treatment. This review discusses current state-of-the art regarding microenvironment, with specific focus on development biomaterials-based delivery strategies their cargos direct microenvironment.

Language: Английский

Citations

42
Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex DOI Creative Commons
Jing Wang, Xinyan Xue, Xingtao Zhao

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 60, P. 183 - 200

Published: Aug. 12, 2023

Acute lung injury (ALI) is a disease characterized by inflammation and still requires further drug development. Forsythiaside A as the active compound of Forsythiae Fructus has therapeutic potential for ALI.

Language: Английский

Citations

31
Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management DOI Open Access
Acharya Balkrishna,

S. Sinha,

Ashwani Kumar

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115183 - 115183

Published: July 22, 2023

Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) one of the most frequent complications underlying sepsis, which portends heavy burden mortality morbidity. Thus, present review aimed to provide insight into recent progression molecular mechanisms targeting dysregulated immune response cellular dysfunction involved development sepsis-associated AKI, accentuating phytoconstituents eligible candidates for attenuating onset AKI. The pathogenesis sepsis-mediated AKI entails complicated mechanism likely involve distinct constellation hemodynamic, inflammatory, mechanisms. Novel biomarkers like neutrophil gelatinase-associated lipocalin, soluble triggering receptor expressed on myeloid cells 1, procalcitonin, alpha-1-microglobulin, presepsin can help more sensitive diagnosis Many bioactive compounds curcumin, resveratrol, baicalin, quercetin, polydatin are reported play important role prevention management by decreasing serum creatinine, blood urea nitrogen, cystatin C, lipid peroxidation, oxidative stress, IL-1β, TNF-α, NF-κB, increasing activity antioxidant enzymes level PPARγ. plant could be developed drug-developing candidate managing acute after detailed follow-up studies. Lastly, gut-kidney axis may promising therapeutic target against septic but deeper understanding pathways still required.

Language: Английский

Citations

30
Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling DOI
Yongmei Tu, Jiangzheng Liu,

Deqin Kong

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 201, P. 98 - 110

Published: March 20, 2023

Language: Английский

Citations

25
Valorization of Grape Pomace: A Review of Phenolic Composition, Bioactivity, and Therapeutic Potential DOI Creative Commons

Anna Karastergiou,

Anne‐Laure Gancel, Michaël Jourdes

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1131 - 1131

Published: Sept. 19, 2024

Vitis vinifera L., commonly known as grapes, is one of the most widely cultivated crops worldwide, with over 80% used for wine production. However, winemaking process generates substantial residues, including grape pomace (GP), lees, and wastewater, which can pose significant environmental economic challenges. Among these, GP stands out not only a waste product but also rich source polyphenols—bioactive compounds recognized antioxidant anti-inflammatory properties. Recent advancements have expanded application GP-derived extracts, particularly in health food industries, due to their potent bioactive This review provides comprehensive overview valorization GP, focusing on its phenolic composition therapeutic potential. It evokes innovative, environmentally friendly extraction techniques integrated methods chemical analysis these valuable compounds. Additionally, benefits polyphenols are explored, recent experimental findings examining metabolism highlighting key role gut microbiota processes. These insights contribute deeper understanding biological activity extracts underscore growing significance high-added-value product. By illustrating how by-products be transformed into natural agents, this emphasizes importance sustainable development eco-friendly management practices, significantly contributing advancement circular economy.

Language: Английский

Citations

16
Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages DOI Creative Commons

Shian Hu,

Zehua Yang, Ling Li

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(1), P. 236 - 236

Published: Jan. 1, 2024

Salvianolic acid B (Sal B) is the primary water-soluble bioactive constituent derived from roots of Salvia miltiorrhiza Bunge. This research was designed to reveal potential mechanism Sal anti-liver injury perspective macrophages. In our lipopolysaccharide-induced M1 macrophage model, showed a clear dose-dependent gradient inhibition trend type. Moreover, downregulated expression lactate dehydrogenase A (LDHA), while overexpression LDHA impaired B’s effect inhibiting polarization. Additionally, this study revealed that exhibited inhibitory effects on lactylation process histone H3 lysine 18 (H3K18la). ChIP-qPCR analysis, observed drive reduction in H3K18la levels promoter region LDHA, NLRP3, and IL-1β genes. Furthermore, vivo experiments has good alleviating CCl4-induced liver injury. An examination tissues Kupffer cells isolated those proved affects polarization macrophages level lactylation. Together, data by downregulating treatment

Language: Английский

Citations

11
Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders DOI

Ahmad Zaid,

Amiram Ariel

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115204 - 115204

Published: Feb. 9, 2024

Language: Английский

Citations

10
The Role of mtDNA Mutations in Atherosclerosis: The Influence of Mitochondrial Dysfunction on Macrophage Polarization DOI Open Access
Evgeniya I. Fedotova, Alexey V. Berezhnov, Daniil Y. Popov

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1019 - 1019

Published: Jan. 25, 2025

Atherosclerosis is a complex inflammatory process associated with high-mortality cardiovascular diseases. Today, there growing body of evidence linking atherosclerosis to mutations mitochondrial DNA (mtDNA). But the mechanism this link insufficiently studied. progression involves different cell types and macrophages are one most important. Due their high plasticity, can demonstrate pro-inflammatory pro-atherogenic (macrophage type M1) or anti-inflammatory anti-atherogenic M2) effects. These two types, formed as result external stimuli, differ significantly in metabolic profile, which suggests central role mitochondria implementation macrophage polarization route. According this, we assume that mtDNA causing disturbances play an internal trigger, leading formation M1 M2. This review provides comparative analysis characteristics function possible associations linked inflammation-based pathologies including atherosclerosis.

Language: Английский

Citations

2