Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(11), P. 2012 - 2012
Published: Nov. 17, 2023
Cancer
metabolic
reprogramming
is
a
complex
process
that
provides
malignant
cells
with
selective
advantages
to
grow
and
propagate
in
the
hostile
environment
created
by
immune
surveillance
of
human
organism.
This
underpins
cancer
proliferation,
invasion,
antioxidant
defense,
resistance
anticancer
immunity
therapeutics.
Perhaps
not
surprisingly,
rewiring
considered
be
one
"Hallmarks
cancer".
Notably,
this
often
comprises
various
complementary
overlapping
pathways.
Today,
it
well
known
highly
inhibition
only
pathways
tumor
cell
leads
limited
response
and,
subsequently,
emergence
resistance.
Therefore,
increase
overall
effectiveness
antitumor
drugs,
advisable
use
multitarget
agents
can
simultaneously
suppress
several
key
processes
cell.
review
focused
on
group
plant-derived
natural
compounds
target
different
cancer-associated
metabolism,
including
aerobic
glycolysis,
respiration,
glutaminolysis,
one-carbon
de
novo
lipogenesis,
β-oxidation
fatty
acids.
We
discuss
those
display
inhibitory
activity
against
as
number
important
signaling
cancer.
Information
about
their
pharmacokinetics
animals
humans
also
presented.
Taken
together,
may
multiple
malignancies,
something
bears
great
potential
for
further
improvement
antineoplastic
therapy.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(12), P. 5435 - 5463
Published: Aug. 30, 2023
Abstract
Cancer
is
the
world's
second
leading
cause
of
mortality
and
one
major
public
health
problems.
incidence
rates
remain
high
despite
great
advancements
in
existing
therapeutic,
diagnostic,
preventive
approaches.
Therefore,
a
quest
for
less
toxic
more
efficient
anti‐cancer
strategies
still
at
forefront
current
research.
Traditionally
important,
curcumin
commonly
known
as
wonder
molecule
has
received
considerable
attention
an
anti‐cancer,
anti‐inflammatory,
antioxidant
candidate.
However,
limited
water
solubility
low
bioavailability
restrict
its
extensive
utility
different
pathological
states.
The
investigators
are
making
consistent
efforts
to
develop
newer
overcome
limitations
by
designing
analogues
with
better
pharmacokinetic
pharmacodynamic
properties.
present
review
highlights
recent
updates
on
special
emphasis
various
mechanistic
pathways
involved
activity.
In
addition,
structure–activity
relationship
also
been
precisely
discussed.
This
article
will
provide
key
information
design
development
desired
profiles
depth
understanding
molecular
activities.
Food Safety and Health,
Journal Year:
2024,
Volume and Issue:
2(1), P. 21 - 38
Published: Jan. 1, 2024
Abstract
Curcuminoids,
resevetrol,
and
quericitin
are
naturally
occurring
compounds
in
various
foods
that
contain
antiviral
functionalities.
Among
them,
curcuminoids
the
lipophilic
phenolic
extracted
from
rhizomes
of
Curcuma
longa
.
L,
a
perennial
plant
Zingiberaceae
family.
Industrial
applications
popularization
still
developing
slowly
due
to
unacceptable
bitter
taste
poor
bioavailability
these
components.
Appropriate
extraction
conditions
play
central
role
obtain
extracts
preserve
biological
activity
curcuminoids.
Green
technologies
can
be
great
value
extract
bioactive
compounds.
Curcuminoids
biologically
effective
terms
molecular
targets
physiological
effects
against
some
main
global
diseases,
such
as
cardiovascular
diabetes,
metabolic
syndrome,
arthritis.
Being
nutraceutical,
its
food
products
could
new
challenge
combat
COVID‐19
like
viral
infections.
This
review
summarized
latest
data
related
chemical
composition,
production,
methods,
potential
health
benefits,
relation
treatment.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(11), P. 5109 - 5158
Published: Aug. 3, 2023
Curcumin,
a
natural
polyphenol,
derived
from
Curcuma
longa
L.
is
extensively
studied
by
various
researchers
across
the
globe
and
has
established
its
immense
potential
in
management
of
several
disorders
at
clinical
level.
The
underlying
mechanism
curcumin
involves
regulation
molecular
targets,
namely,
inflammatory
cytokines,
transcription
factor,
apoptotic
genes,
growth
factors,
oxidative
stress
biomarkers,
protein
kinases.
In
trials,
as
an
adjuvant
significantly
boost-up
efficacy
many
proven
drugs
arthritis,
neurodegenerative
disorder,
oral
infection,
gastrointestinal
disorders.
Moreover,
studies
have
suggested
appropriate
candidate
for
prevention
and/or
cancers
via
signaling
molecules
including
NF-kB,
C-reactive
protein,
prostaglandin
E2,
Nrf2,
HO-1,
ALT,
AST,
kinases,
blood
profiles.
This
article
highlights
plethora
trials
that
been
conducted
on
derivatives
ailments.
Besides,
it
provides
recent
updates
to
investigators
conducting
future
research
fulfill
current
gaps
expedite
utility
subjects
bearing
different
pathological
states.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(11), P. 2012 - 2012
Published: Nov. 17, 2023
Cancer
metabolic
reprogramming
is
a
complex
process
that
provides
malignant
cells
with
selective
advantages
to
grow
and
propagate
in
the
hostile
environment
created
by
immune
surveillance
of
human
organism.
This
underpins
cancer
proliferation,
invasion,
antioxidant
defense,
resistance
anticancer
immunity
therapeutics.
Perhaps
not
surprisingly,
rewiring
considered
be
one
"Hallmarks
cancer".
Notably,
this
often
comprises
various
complementary
overlapping
pathways.
Today,
it
well
known
highly
inhibition
only
pathways
tumor
cell
leads
limited
response
and,
subsequently,
emergence
resistance.
Therefore,
increase
overall
effectiveness
antitumor
drugs,
advisable
use
multitarget
agents
can
simultaneously
suppress
several
key
processes
cell.
review
focused
on
group
plant-derived
natural
compounds
target
different
cancer-associated
metabolism,
including
aerobic
glycolysis,
respiration,
glutaminolysis,
one-carbon
de
novo
lipogenesis,
β-oxidation
fatty
acids.
We
discuss
those
display
inhibitory
activity
against
as
number
important
signaling
cancer.
Information
about
their
pharmacokinetics
animals
humans
also
presented.
Taken
together,
may
multiple
malignancies,
something
bears
great
potential
for
further
improvement
antineoplastic
therapy.
