Oxidative Stress, Endothelial Dysfunction, and N-Acetylcysteine in Type 2 Diabetes Mellitus

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(16-18), P. 968 - 989

Published: March 18, 2024

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Endothelial dysfunction is closely associated with development progression CVDs. Patients diabetes mellitus (DM) especially type 2 DM (T2DM) exhibit a significant endothelial cell (EC) substantially increased risk for

Language: Английский

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Roles of vitamins and nutrition in obstructive sleep apnea

Expert Review of Respiratory Medicine, Journal Year: 2025, Volume and Issue: 19(2), P. 145 - 163

Published: Feb. 1, 2025

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder, with a prevalence that rises alongside increasing of obesity. OSA characterized by low-inflammatory state and followed cardiovascular metabolic sequelae. Continuous positive airway pressure (CPAP) represents cornerstone treatment for severe OSA. However, poor compliance CPAP renders challenging venture. Weight loss exercise are recommended as adjunctive options Several diets have proven to facilitate weight loss, alleviate inflammatory status in patients Moreover, several vitamins exhibit antioxidant properties beneficially affect pathology reduce risk complications. This narrative review aims summarize current knowledge regarding effect nutrition vitamin deficiencies on Included were publications, relevant topic, different types design (i.e. cross-sectional studies, cohort clinical trials, systematic reviews, meta-analyses, etc.) indexed PubMed database until 31 March 2024. In addition other food components, such proteins, carbohydrates, anti-inflammatory agents, A, B, C, D, E, sodium, may play beneficial role incidence severity

Language: Английский

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Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 203 - 203

Published: Feb. 10, 2025

The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.

Language: Английский

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Production, Composition and Nutritional Properties of Organic Milk: A Critical Review

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 550 - 550

Published: Feb. 11, 2024

Milk is one of the most valuable products in food industry with milk production throughout world being carried out using conventional management, which includes intensive and traditional systems. The use fertilizers, antibiotics, pesticides concerns regarding animal health environment have given increasing importance to organic dairy last two decades. This review aims compare production, nutritional, compositional properties produced by management We also shed light on benefits worldwide scenario system. Most reports suggest has beneficial effects very few, if any, adverse reported. Organic reported confer additional due its lower omega-6-omega-3 ratio, difference feeding practices, cows predominantly pasture fed. Despite testified animal, host, environmental benefits, difficult several regions cost-intensive process geographical conditions. Finally, we offer perspectives for a better future highlight knowledge gaps

Language: Английский

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Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2413 - 2413

Published: May 22, 2023

The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved the genesis development of many world-scale public health burdens, such as metabolic cardiovascular diseases. In recent years, bee pollen emerging scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix being extensively studied, has proven very rich well-balanced nutrient pool. this work, we reviewed available evidence interest source. We mainly focused richness nutrients its possible roles main pathophysiological processes that are directly linked imbalances. scoping review analyzed scientific works published last four focusing clearest inferences perspectives translate cumulated experimental preclinical into clinically relevant insights. promising uses for malnutrition, digestive health, disorders, other bioactivities could helpful readjust homeostasis (as it also true case anti-inflammatory or anti-oxidant needs), well benefits diseases, were identified. knowledge gaps identified, along with practical challenges hinder establishment fructification these uses. A complete data collection made major range botanical species allows more robust clinical information.

Language: Английский

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Eco-friendly Synthesis of Zinc Oxide Nanoparticles by Clerodendrum heterophyllum Leaf Extract and Their Biological Applications

BioNanoScience, Journal Year: 2023, Volume and Issue: 13(4), P. 2252 - 2264

Published: Oct. 21, 2023

Language: Английский

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A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117638 - 117638

Published: Jan. 1, 2025

Environmental pollutants including ultrafine particulate matter (UFPs) and adverse meteorological conditions pose significant public health impacts, particularly affecting respiratory health. This study aims to elucidate the synergistic effects of cold-humid UFPs exposure on health, utilizing Carbon Black Nanoparticles (CB-NPs) as surrogates for UFPs. Through comprehensive lung function tests, histopathological examinations, biomarker analyses, this research focuses modulation oxidative stress signaling pathways NF-κB activation. Male Balb/c mice were exposed specific concentrations CB-NPs (30-50 nm in diameter, 0.184 mg/(kg·day)) a controlled environmental chamber mimicking cold (10°C/14°C) humid (90 % RH) over three weeks. The results indicate that alone increased function, (ROS, GSH, MDA), inflammation (IL-6, TNF-α, IL-1β), apoptosis (Caspase 3, Caspase 8, 9), alterations tissue. Furthermore, these notably more severe under combined with conditions. These suggest are not solely concentration-dependent but exacerbated by contexts. It is evident Vitamin E (100 mg/kg/day) can attenuate effects, underscoring its potential protective agent against stressor-induced air Our findings factors pollutant significantly impact providing valuable insights design healthier indoor environments development strategies mitigate risks.

Language: Английский

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Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications

Free Radical Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 7, 2025

Naturally occurring vitamin E is a lipophilic plant-derived molecule corresponding to the 2 R forms of alpha-tocopherol. A series natural analogs or tocochromanols are present in nature, including β-, γ- and δ-tocopherol (βT, γT, δT), tocotrienols (αTE, βTE, γTE, δTE) tocomonoenols. Differences between these as antioxidants modulators molecular processes suggest specific therapeutic properties against various disorders associated with acute chronic inflammation. However, hepatic metabolism compounds via cytochrome P450-initiated side chain ω-oxidation involves production long-chain metabolites (LCMs) followed by intermediate (ICMs) short-chain (SCMs), respectively. Despite initial studies indicating catabolic-end products, recent findings identify their importance providing biological functions. In this scope, LCMs, especially 13'-carboxychromanols (13'-COOHs), have been reported hold stronger anti-inflammatory capacity than unmetabolized precursors due ability inhibit 5-lipoxygenase cyclooxygenase-catalyzed eicosanoid formation, well modulation pro-inflammatory transcriptional protein nuclear factor κB (NF-κB). Also, LCMs enhance detoxification lipid pathways cellular inflammation modulating receptors peroxisome proliferator-activated receptor-γ (PPARγ) pregnane x receptor (PXR). These will be described narrative review article focusing on information regarding bioavailability, effects, mechanisms action inflammatory disorders.

Language: Английский

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Recent advances in chemical composition imaging operation based on laser-induced breakdown spectroscopy

Journal of Analytical Atomic Spectrometry, Journal Year: 2025, Volume and Issue: 40(3), P. 665 - 678

Published: Jan. 1, 2025

This review provides a comparatively comprehensive and systematic introduction to recent developments in chemical composition imaging based on LIBS, with focus the principle, operation, development.

Language: Английский

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Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 28, 2025

Background Hypovitaminosis, or vitamin deficiency, has been increasingly recognized as a potential contributing factor in the development of recurrent aphthous stomatitis (RAS), condition characterized by periodic formation painful ulcers oral mucosa. Materials and methods This mini review includes literature search on PubMed, Web Science, Scopus databases using keywords “hypovitaminosis AND ulcers.” Results There is growing body evidence supporting link between various deficiencies—particularly vitamins B12, C, folate—and prevalence RAS, with implications for both diagnosis management. Conclusion aims to outline clinical biochemical findings associated hypovitaminosis individuals presenting emphasizing diagnostic importance recognizing deficiencies these patients exploring possible therapeutic approaches.

Language: Английский

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