Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

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New insights into bee pollen: Nutrients, phytochemicals, functions and wall-disruption

Food Research International, Journal Year: 2024, Volume and Issue: 178, P. 113934 - 113934

Published: Jan. 4, 2024

Language: Английский

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Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 352 - 352

Published: July 4, 2023

The field of biomedical engineering highly demands technological improvements to allow the successful engraftment biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one primary suitable materials employed functionalized enhance their biocompatibility thus confer advantageous features after graft implantation. Incorporating bioactive substances from nature is a good technique expanding or increasing functionality biomaterial scaffolds, which may additionally encourage healing. Our ecosystem provides resources, like honeybee products, comprising rich blend phytochemicals with interesting properties, which, when functionally coupled biomaterials, result in exhibiting anti-inflammatory, antimicrobial, antioxidant effects. Bee pollen sustainable product recently discovered as new functionalizing agent biomaterials. This review aims articulate general idea using products engineering, mainly focusing on describing recent literature experimental studies bee pollen. We have also described underlying mechanism attributes shared our perspective how future research will benefit fabrication such

Language: Английский

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Antioxidant and Tyrosinase-Inhibitory Activities and Biological Bioactivities of Flavonoid Derivatives from Quercus mongolica Pollen

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 794 - 794

Published: Feb. 8, 2025

Flavonoids, present in plants as enriched secondary metabolites, prevent various stresses such temperature fluctuations, acidity, and insect predation, are commonly found leaves, stems, flowers, serve important bioactive components. In this study, a total of eighteen different flavonoids, including one newly identified flavonoid glycoside, were successfully isolated from the pollen Quercus mongolica. The structure novel compound was determined using nuclear magnetic resonance, mass spectrometry, infrared spectroscopy. Additionally, GC analysis conducted to determine sugar moiety new compound, confirming specific type disaccharide present. 18 compounds classified glycosides (1-10), flavonoids (11-17), isoflavone (18). All evaluated for their tyrosinase inhibitory antioxidant activities, structure-activity relationships (SARs) also evaluated. Compounds 12 16 showed higher activities compared kojic acid positive control. 2, 5, 8, 12, 13, 14, demonstrated potent activities. Among these compounds, 5 even activity than ascorbic acid. Structure-activity relationship revealed that tyrosinase-inhibitory enhanced with hydroxy group C-3 or C-3't aglycones glycosides. These findings indicate and/or extracts Q. mongolica valuable natural resources applications pharmaceutical cosmetic industries.

Language: Английский

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Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

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Protective Effects of Melatonin and Bee Pollen on Hematotoxicity and Hepatorenal Toxicity Induced by Long-Term Intake of Gabapentin in Female Albino Rats

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 613 - 613

Published: May 10, 2024

Clinical practice entails a translation of research that assists in the use scientific data and therapeutic evidence for benefit patient. This review critically summarizes potential impact cannabinoids conjunction with other drugs when associated treatments epilepsy, autism spectrum disorder, cancer, multiple sclerosis, chronic pain. In these associations, drug interactions may occur alter predicted clinical results. Therefore, must always be assessed to avoid failures and/or increased side effects. Some effects additive, synergistic, or antagonistic, but changes absorption, distribution, metabolism, particularly through cytochrome P450 (CYP) isoenzymes (e.g., CYP2C9 CYP3A4), excretion also occur. For example, combination cannabis-derived compounds antifungal ketoconazole, CYP3A4 inhibitor, increases plasma concentration Δ-9-tetrahydrocannabinol (THC) cannabidiol (CBD). contrast, rifampicin, inducer, stands out reducing THC levels by approximately 20–40% 50% 60% CBD. Other inhibitors inducers are likely have similar effect on concentrations if co-administered. Pharmacokinetic anticonvulsant medications been reported, as pharmacodynamic between sympathomimetic tachycardia, hypertension), central nervous system depressants drowsiness, ataxia), anticholinergics tachycardia somnolence). Although further studies still pending, there is currently supporting cannabinoids, requiring doctors evaluate risk combinations vice versa. The tables provided here were designed facilitate identification biorelevant compromise efficacy toxicity.

Language: Английский

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Bee pollen beyond nutrition: An integrated review of its chemical, pharmacological, and biological properties

Journal of Drug Research in Ayurvedic Sciences, Journal Year: 2024, Volume and Issue: 9(4), P. 211 - 221

Published: July 1, 2024

Abstract Bee pollen, renowned for its nutritional richness and therapeutic properties, harbors a complex array of compounds influenced by geographical origins plant sources. In recent years, bee pollen has gained significant attention owing to recognized potential health benefits value. A systematic review was undertaken, encompassing peer-reviewed articles, clinical trials, ethnobotanical studies, gather pertinent information on chemical constituents, physiological effects human health. The assessment emphasizes the composition comprising carbohydrates, proteins, amino acids, lipids, vitamins, minerals, bioactive like flavonoids, phenolic enzymes. Various analytical methods have been employed characterize components highlighting composition. contains life-essential making up an average 22.7%, essential acids such as isoleucine, lysine, threonine, histidine, leucine, valine, phenylalanine, methionine, tryptophan. Geographical variations emphasize diversity, underscoring need comprehensive analysis. Contemporary scientific investigations initiated revelation pollen’s benefits. Beyond value, exhibits spectrum biological activities, including antimicrobial, antifungal, antioxidant, anti-tumor, neuroprotective, anti-inflammatory, anticancer, immunostimulatory, hepatoprotective effects, suggesting value in addressing conditions. Additionally, different systems, cardiovascular, digestive, reproductive, respiratory are explored. Recognized pivotal resource medicinal development, warrants scrutiny fully unravel multifaceted activities potential. objective this study is offer thorough exploration background existing literature concerning pollen. seeks examine detail composition, importance, applications, associated with Further may pave way creation innovative agents supplements, enriching both traditional evidence-based healthcare approaches.

Language: Английский

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Unveiling bee pollen's contamination with pesticides and mycotoxins: Current analytical procedures, results and regulation

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117935 - 117935

Published: Aug. 28, 2024

Language: Английский

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Importance of pollinator diversity for sunflower seed production

Agrology, Journal Year: 2023, Volume and Issue: 6(4), P. 79 - 85

Published: Nov. 4, 2023

The sunflower (Helianthus annuus Linnaeus) is one of the most important food crops in world. In modern agroecology, this pivotal plant deeply intertwined with diverse pollination mechanisms. This study elucidates multifaceted contributions various pollinator taxa, delving into their respective efficiencies and behaviors vis-à-vis reproductive success. honeybee (Apis mellifera Linnaeus, 1758) plays a central role pollination, transferring pollen over large distances, thereby bolstering genetic diversity populations. While sunflowers derive immense benefits from they reciprocally offer as vital nutrition for bee larvae. However, symbiotic relationship nuanced, honeybees occasionally exhibiting selectivity based on cultivar. are paramount, richness ecosystem further accentuated by presence other pollinators, each contributing uniquely to sunflower’s lifecycle. foraging fidelity solitary bees, such leafcutter (Megachile spp.) mason (Osmia spp.), underscores indispensable cross-pollination. Bumblebees (Bombus introduce fascinating "buzz pollination" mechanism, leveraging vibrations optimize release. Simultaneously, wasps provide functions beyond serving biocontrol agents preying detrimental pests. Surprisingly, mosquitoes appeared also be contributors especially when traditional pollinators scarce, nocturnal tendencies augmenting continuity. Hoverflies render dual benefits: aid larvae predate butterflies primarily nectar-oriented, inadvertently partake transfer. Moths, through activities, complement pollination. Beetles, often overlooked, act secondary pollinators. Regrettably, contemporary agricultural practices disrupt ecological equilibrium. Pervasive pesticide use habitat fragmentation imperil these underscoring urgent need pollinator-friendly approaches. As climate conditions fluctuate, understanding dynamics becomes increasingly critical. comprehensive examination advocates holistic conservation strategies, targeting sustained yields broader resilience.

Language: Английский

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