Ramon Flour (Brosimum alicastrum Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model DOI Creative Commons

Trinidad Eugenia Cu-Cañetas,

Laura A. Velázquez‐Villegas,

Mariana Manzanilla-Franco

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1957 - 1957

Published: Nov. 2, 2023

Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity the development metabolic alterations. Ramon seed is Mayan used obtain flour (RF) high biological value terms protein, fiber, micronutrients, bioactive compounds such as polyphenols. However, few studies have evaluated beneficial effects RF. Thus, we aimed determine RF on high-fat-diet-induced mouse model. We divided male BALB/c mice into four groups (n = 5 each group) fed them for 90 days following diets: Control (C): control diet (AIN-93), C + RF: adjusted 25% RF, HFD: high-fat 5% sugar water, HFD water. The prevented increase serum total cholesterol (TC) alanine transaminase (ALT) that occurred groups. Notably, increased polyphenols antioxidant activity, it promoted adipocyte size white adipose tissue, along lower hepatic lipid accumulation than group. In liver, group showed an expression β-oxidation-related genes, downregulation fatty acid synthase (Fas) gene compared Moreover, had phosphorylation AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related 2 (NRF2) superoxide dismutase (SOD2) may be nutritional strategy alterations during obesity.

Language: Английский

Stimulation of Auricular Vagus Nerve Ameliorates Chronic Stress induced Metabolic Syndrome via Activation of Sirtuin-6 DOI
Arjun Singh Kaushik, Vipul Agarwal, Neeraj Kumar

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151567 - 151567

Published: March 5, 2025

Language: Английский

Citations

1
Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective DOI Creative Commons
Yansong Fu, Zhipeng Wang, Hong Qin

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 218 - 218

Published: April 12, 2024

Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent worldwide, affecting approximately two-fifths of global population. The pathogenesis MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in progression MAFLD, including lipids, carbohydrates, amino acids, micronutrients. In recent years, medicinal properties natural products have attracted widespread attention, numerous studies reported their efficacy ameliorating subsequently alleviating MAFLD. This review aims summarize metabolic-associated pathological mechanisms as well regulate pathways alleviate

Language: Английский

Citations

8
Preparation, identification and in vivo study of antioxidant peptides from Haematococcus pluvialis residue DOI
Yuling Zhang, Mengjia Zhu, Qingxin Zhou

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106140 - 106140

Published: Feb. 1, 2025

Language: Английский

Citations

0
Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats DOI
Hatice Çolak, Esra Tansu Sarıyer, Meral Yüksel

et al.

Archives of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 23, 2025

This study investigated bee bread's (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, apoptosis. Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline BB before 3-day after ulcer induction. Stomachs of decapitated rats collected index, histological biochemical analyses. significantly reduced the index levels chemiluminescence, HMGB-1, IL-6, IL-1ß IL-8 pretreatment groups. In BB-pretreated group, MPO-(saline\BB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) IFN-γ (15.46±1.76;9.51±1.95 decreased TNF-α (31.77±5.13;18.94±2.59 only BB-treated MDA, GSH, NRF-2, 8-OHdG remained unchanged. has demonstrated reducing ROS production, modulating inflammation

Language: Английский

Citations

0
Exploring the therapeutic potential of propolis in managing diabetes: a preclinical study DOI Creative Commons

Hannah Shi Tiang,

Lingling Qin, Tonghua Liu

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Health Benefits and Uses of Bee Bread in Medicine DOI
Adriana Cristina Urcan

Published: Jan. 1, 2025

Language: Английский

Citations

0
Chemical Composition of Bee Bread DOI
Adriana Cristina Urcan

Published: Jan. 1, 2025

Language: Английский

Citations

0
Saponins of Tomato Extract Improve Non-Alcoholic Fatty Liver Disease by Regulating Oxidative Stress and Lipid Homeostasis DOI Creative Commons
Ziming Yang, Li Zhang, Jinlei Liu

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1848 - 1848

Published: Oct. 12, 2023

The present study investigated the impact of saponins tomato extract (STE) on non-alcoholic fatty liver disease (NAFLD). findings demonstrated that introducing STE in NAFLD mice revealed promising results ameliorating symptoms oxidative stress, lipid metabolism disorders, visceral fat deposition and disease. Moreover, mechanistic studies have delivers its effects by activating adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), thereby suppressing downstream expression associated with acid synthesis. In such conditions, can be improved. Simultaneously, enhanced nuclear factor erythroid 2-related 2 (Nrf2) entry into nucleus initiated transcription antioxidant factors, relieving stress induced a high-fat diet lowering damage to liver. Such imply administration regarded as viable treatment option for NAFLD, providing mechanism regulate AMPK Nrf2 signaling pathways.

Language: Английский

Citations

6
Raw Cured Poultry Meat Fortified with Bee Pollen: Biomedical Research on Laboratory Animals DOI Creative Commons
M.A. Sukhov, T.M. Giro, Serguei Kozlov

et al.

Food Processing Techniques and Technology, Journal Year: 2023, Volume and Issue: 53(4), P. 775 - 785

Published: Dec. 30, 2023

Natural food additives can fortify meat products. Bee pollen, also known as beebread or ambrosia, contains amino acids, carbohydrates, vitamins, minerals, enzymes, etc. As a result, it possesses numerous therapeutic and prophylactic properties. pollen has good prospects fortifying agent for jerky meat, i.e., lean dehydrated trimmed cut into strips. This study tested dry-cured fortified with bee on rats carbon tetrachloride-induced acute toxic hepatitis. The research featured white non-linear laboratory rats. control group obtained standard diet. experimental were induced liver hepatitis by administering CCl4. On day 2, the was divided three subgroups: I (standard diet + traditional jerky), II pollen), III diet), which served positive control. involved MicroCC20Vet analyzer hematological tests StatFax 3300 Diacon DS diagnostic systems biochemical tests. histological analyses relied method developed G.A. Merkulov. parameters demonstrated no changes. biochemistry, groups protein content increase. 14, concentration of its fractions in reached level intact animals. In III, total significantly higher due to globulin fraction result inflammatory destructive processes liver. However, had normal live weight gain, their deviations. this preclinical study, part formulation negative effect proved antioxidant

Language: Английский

Citations

1
Ramon Flour (Brosimum alicastrum Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model DOI Creative Commons

Trinidad Eugenia Cu-Cañetas,

Laura A. Velázquez‐Villegas,

Mariana Manzanilla-Franco

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1957 - 1957

Published: Nov. 2, 2023

Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity the development metabolic alterations. Ramon seed is Mayan used obtain flour (RF) high biological value terms protein, fiber, micronutrients, bioactive compounds such as polyphenols. However, few studies have evaluated beneficial effects RF. Thus, we aimed determine RF on high-fat-diet-induced mouse model. We divided male BALB/c mice into four groups (n = 5 each group) fed them for 90 days following diets: Control (C): control diet (AIN-93), C + RF: adjusted 25% RF, HFD: high-fat 5% sugar water, HFD water. The prevented increase serum total cholesterol (TC) alanine transaminase (ALT) that occurred groups. Notably, increased polyphenols antioxidant activity, it promoted adipocyte size white adipose tissue, along lower hepatic lipid accumulation than group. In liver, group showed an expression β-oxidation-related genes, downregulation fatty acid synthase (Fas) gene compared Moreover, had phosphorylation AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related 2 (NRF2) superoxide dismutase (SOD2) may be nutritional strategy alterations during obesity.

Language: Английский

Citations

0