Gut microbiota in neurological diseases: Melatonin plays an important regulatory role

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116487 - 116487

Published: March 21, 2024

Melatonin is a highly conserved molecule produced in the human pineal gland as hormone. It known for its essential biological effects, such antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut one of primary sources melatonin. microbiota helps produce melatonin from tryptophan, has been shown to have beneficial effect on barrier function microbial population. Dysbiosis intestinal associated with bacterial imbalance decreased metabolites, including In this way, low levels may be related several diseases. both preventive therapeutic effects against various conditions, neurological diseases Alzheimer's disease, Parkinson's multiple sclerosis. This review was aimed discuss role body, describe possible relationship between production, well potential

Language: Английский

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Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7579 - 7579

Published: April 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1422 - 1422

Published: May 8, 2024

Breastfeeding is the most appropriate source of a newborn’s nutrition; among plethora its benefits, modulation circadian rhythmicity with melatonin as potential neuroendocrine transducer has gained increasing interest. Transplacental transfer assures provision for fetus, who devoid secretion. Even after birth, neonatal pineal gland not able to produce rhythmically several months (with an even more prolonged deficiency following preterm birth). In this context, human breast milk constitutes main natural melatonin: diurnal dynamic changes, acrophase early midnight, and changes in concentrations according gestational age during different stages lactation have been reported. Understudied thus far are factors impacting on (changes in) content their clinical significance chronobiological adherence neonate: maternal well environmental aspects be investigated detail guide nursing mothers optimal feeding schedules which probably means synchronized instead mistimed practice. This review aims thought-provoking regarding critical role chrononutrition breastfeeding, highlighting entrainment therefore optimizing (neuro)developmental outcomes setting.

Language: Английский

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Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 309 - 330

Published: June 21, 2024

Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.

Language: Английский

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Melatonin in Health and Disease: A Perspective for Livestock Production

Biomolecules, Journal Year: 2023, Volume and Issue: 13(3), P. 490 - 490

Published: March 7, 2023

Mounting evidence in the literature indicates an important role of endogenous and exogenous melatonin driving physiological molecular adaptations livestock. Melatonin has been extensively studied seasonally polyestrous animals whereby supplementation studies have used to adjust circannual rhythms herds under abnormal photoperiodic conditions. Livestock undergo multiple metabolic adaptation processes throughout their production cycle which can result decreased immune response leading chronic illness, weight loss, or efficiency; however, melatonin’s antioxidant capacity immunostimulatory properties could alleviate these effects. The cardiovascular system responds depending on receptor type localization, vasodilate vasoconstrict several systemic arteries, thereby controlling whole animal nutrient partitioning via vascular resistance. Increased incidences non-communicable diseases populations exposed circadian disruption uncovered novel pathways neurohormones, such as melatonin, influence health, disease. Perturbations function negatively impact growth development livestock examined following supplementation. Specifically, uptake, circulating profiles, endocrine profiles economically development. This review focuses physiological, cellular, implications health disease domesticated food animals.

Language: Английский

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Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

eLife, Journal Year: 2023, Volume and Issue: 12

Published: June 20, 2023

Intercellular signalling is an indispensable part of multicellular life. Understanding the commonalities and differences in how molecules function two remote branches tree life may shed light on reasons these were originally recruited for intercellular signalling. Here we review plant three highly studied animal molecules, namely glutamate, γ-aminobutyric acid (GABA), melatonin. By considering both their plants broader physiological function, suggest that with original as key metabolites or active participants reactive ion species scavenging have a high chance becoming molecules. Naturally, evolution machinery to transduce message across plasma membrane necessary. This fact demonstrated by other well-studied serotonin, dopamine, acetylcholine, which there currently no evidence they act plants.

Language: Английский

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Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1236 - 1236

Published: April 21, 2024

Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly associated with immune system dysregulation and dysbiosis, leading to inflammation in the gastrointestinal tract (GIT) multiple extraintestinal manifestations. The pathogenesis IBD not completely elucidated. However, it an increased risk colorectal cancer (CRC), which one most common malignancies. In both CRC, complex interplay occurs between gut microbiota (GM), alteration GM composition. Melatonin, neuroendocrine hormone, was found be involved this interplay, especially since present high amounts gut, some protective effects. Actually, melatonin enhances integrity intestinal mucosal barrier, regulates response, alleviates inflammation, attenuates oxidative stress. Thereby, authors summarize multifactorial interaction focusing on new findings related mechanisms action addition its documented positive outcomes treatment these two pathologies possible future perspectives use as adjuvant therapy.

Language: Английский

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Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 3, 2025

Language: Английский

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The Effect of Sleep Disruption on Cardiometabolic Health

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 60 - 60

Published: Jan. 7, 2025

Sleep disruption has emerged as a significant public health concern with profound implications for metabolic health. This review synthesizes current evidence demonstrating the intricate relationships between sleep disturbances and cardiometabolic dysfunction. Epidemiological studies have consistently demonstrated that insufficient duration (<7 h) poor quality are associated increased risks of obesity, type 2 diabetes, cardiovascular disease. The underlying mechanisms multifaceted, involving circadian clock genes, alterations in glucose lipid metabolism, activation inflammatory pathways, modulation gut microbiome. loss affects key regulators, including AMPK signaling disrupts secretion hormones such leptin ghrelin. latest points to role sleep-induced changes composition function microbiota, which may contribute dysfunction through modifications intestinal barrier responses. NLRP3 inflammasome NF-κB pathways been identified crucial mediators linking inflammation. An understanding these clinical practice, suggesting improving could be an effective strategy preventing treating disorders modern society.

Language: Английский

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