Exploring the Relationship between Antioxidant Enzymes, Oxidative Stress Markers, and Clinical Profile in Relapsing–Remitting Multiple Sclerosis
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1638 - 1638
Published: Aug. 19, 2023
We
aimed
to
investigate
the
extent
of
alterations
in
pro/antioxidant
balance
blood
patients
with
relapsing-remitting
multiple
sclerosis
(RRMS)
relation
drug-modified
therapy,
gender,
disability
score,
and
disease
duration.
161
(67
men
94
women,
aged
24-69
years,
median
43.0)
29
healthy
individuals
(9
20
25-68
41.0)
were
included
study.
measured
activity
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPx),
catalase
(CAT)
as
well
concentration
interleukin-6
(IL-6),
lipid
peroxidation
parameters
(LPO),
total
oxidant
status
(TOS),
antioxidant
capacity
(TAS).
The
SOD
did
not
show
any
significant
differences
between
RRMS
control
group
our
In
contrast,
decreased
GPx
increased
CAT
was
observed
compared
group.
Additionally,
influenced
by
gender
use
disease-modifying
therapies.
Disease-modifying
therapies
also
affected
TOS,
TAS,
LPO.
Our
studies
indicated
that
enhancing
may
be
more
beneficial
providing
potential
therapeutic
strategies
at
modulating
defenses
mitigate
oxidative
stress
this
disease.
Language: Английский
Oxidative Stress Markers in Multiple Sclerosis
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6289 - 6289
Published: June 7, 2024
The
pathogenesis
of
multiple
sclerosis
(MS)
is
not
completely
understood,
but
genetic
factors,
autoimmunity,
inflammation,
demyelination,
and
neurodegeneration
seem
to
play
a
significant
role.
Data
from
analyses
central
nervous
system
autopsy
material
patients
diagnosed
with
sclerosis,
as
well
studies
in
the
main
experimental
model
autoimmune
encephalomyelitis
(EAE),
suggest
possibility
role
oxidative
stress
well.
In
this
narrative
review,
we
summarize
data
reported
on
markers
MS
models
(mainly
EAE),
case–control
association
possible
candidate
genes
related
risk
for
MS.
Most
have
shown
an
increase
stress,
decrease
antioxidant
substances,
or
both,
cerebrospinal
fluid
serum/plasma
malonyl-dialdehyde
being
most
reliable
markers.
This
topic
requires
further
prospective,
multicenter
long-term
follow-up
period
involving
large
number
controls.
Language: Английский
Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis
Junjie Jian,
No information about this author
Jun Wei
No information about this author
Frontiers in Bioscience-Landmark,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: Jan. 6, 2025
Multiple
sclerosis
(MS)
is
a
chronic
autoimmune
disorder
marked
by
neuroinflammation,
demyelination,
and
neuronal
damage.
Recent
advancements
highlight
novel
interaction
between
iron-dependent
cell
death,
known
as
ferroptosis,
gut
microbiota,
which
may
significantly
influences
the
pathophysiology
of
MS.
Ferroptosis,
driven
lipid
peroxidation
tightly
linked
to
iron
metabolism,
pivotal
contributor
oxidative
stress
observed
in
Concurrently,
affect
systemic
immunity
neurological
health,
emerges
an
important
regulator
homeostasis
inflammatory
responses,
thereby
influencing
ferroptotic
pathways.
This
review
investigates
how
microbiota
dysbiosis
ferroptosis
impact
MS,
emphasizing
their
potential
therapeutic
targets.
Through
integrated
examination
mechanistic
pathways
clinical
evidence,
we
discuss
targeting
these
interactions
could
lead
interventions
that
not
only
modulate
disease
progression
but
also
offer
personalized
treatment
strategies
based
on
profiling.
synthesis
aims
at
deepening
insights
into
microbial
contributions
implications
setting
stage
for
future
research
exploration.
Language: Английский
The Connection Between Oxidative Stress, Mitochondrial Dysfunction, Iron Metabolism and Microglia in Multiple Sclerosis: A Narrative Review
NeuroSci,
Journal Year:
2025,
Volume and Issue:
6(1), P. 23 - 23
Published: March 4, 2025
In
recent
years,
in
the
pathogenesis
of
multiple
sclerosis,
emphasis
has
been
placed
on
mitochondrial
processes
that
influence
onset
disease.
Oxidative
stress
would
be
one
consequences
dysfunction,
and
its
impact
brain
tissue
is
well
described.
Microglia,
as
a
macrophage,
have
an
important
function
removing
unwanted
metabolites,
iron,
which
amplifier
oxidative
stress.
There
are
novelties
terms
connection
between
these
processes,
redirected
research
more
towards
process
neurodegeneration
itself,
so
no
longer
neuroinflammation,
initiate
pathological
itself
still
exist
vicinity
lesions
with
reduced
intensity.
The
aim
this
review
to
summarize
current
knowledge
from
literature
regarding
stress,
dysfunction
iron
metabolism
how
microglia
involved
sclerosis.
Language: Английский
Protective Role of High-Density Lipoprotein in Multiple Sclerosis
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1276 - 1276
Published: Oct. 23, 2024
Multiple
sclerosis
(MS)
is
a
chronic,
progressive
demyelinating
disease
with
most
likely
autoimmune
background
and
neurodegenerative
component.
Besides
the
process
caused
by
autoreactive
antibodies,
an
increased
permeability
in
blood-brain
barrier
(BBB)
also
plays
key
role.
Recently,
there
has
been
growing
interest
assessing
lipid
profile
alterations
patients
MS.
As
result
of
myelin
destruction,
increase
level
cholesterol
released
from
cells,
which
turn
causes
disruptions
metabolism
homeostasis
both
central
nervous
system
(CNS)
peripheral
tissues.
Currently,
body
evidence
suggesting
protective
role
HDL
MS
through
its
effect
on
BBB
decreasing
permeability.
This
follows
impact
endothelium
anti-inflammatory
effect,
mostly
interacting
adhesion
molecules
like
vascular
cell
molecule
1
(VCAM-1),
intercellular
(ICAM-1),
E-selectin.
HDL,
action
via
sphingosine-1-phosphate,
exerts
inhibitory
leukocyte
migration,
antioxidant
properties
contribute
to
improvement
function.
In
this
review,
we
want
summarize
these
studies
focus
as
mediator
response
Language: Английский