Non-thermal plasma as a pretreatment for extraction of herbal tea by-products DOI Creative Commons
Jovana Grbić, Mihajlo Bogdanović, Dragana Mladenović

et al.

Journal on Processing and Energy in Agriculture, Journal Year: 2023, Volume and Issue: 27(2), P. 47 - 52

Published: Jan. 1, 2023

Traditional extraction methods involve the use of polar solvents and/or high temperatures. Both are often energy or timeconsuming and require additional purification steps. This compromises quality extracts obtained. Non-thermal plasma pretreatment for is a promising technique that could increase sustainability process while following principles hurdle technology. In this work, we investigated effects treatment on aqueous antioxidant compounds from herbal tea by-products. Stinging nettle, hoary willowherb, St. John's Wort were treated with at different time intervals. The obtained analyzed their capacity total phenolic content. Their potential as growth media Ligilactobacillus sp. was also investigated. Hoary willowherb showed highest content activity. While slightly decreased these extracts, it improved microbial growth. contrast to stinging nettle extracts' not affected by treatment. These better bacterial When added 25% v/v Mrs broth, achieved rate similar pure broth (~10⁹ CFU/ml), demonstrating biomass production food feed supplementation.

Language: Английский

Phytochemical Insights and Therapeutic Potential of Chamaenerion angustifolium and Chamaenerion latifolium DOI Creative Commons
Akmaral Kozhantayeva, Zhanar Iskakova,

Manshuk Ibrayeva

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1186 - 1186

Published: March 6, 2025

The Chamaenerion genus, particularly angustifolium and latifolium, is recognized for its rich phytochemical composition extensive medicinal properties. These species are abundant in polyphenols, flavonoids, tannins, which contribute to their potent antioxidant, antimicrobial, anticancer activities. This review provides a comprehensive analysis of constituents, with an emphasis on how processing methods, including fermentation, influence bioactivity. Notably, fermentation enhances the levels key bioactive compounds, such as oenothein B, gallic acid, ellagic thereby increasing pharmacological potential. Additionally, this evaluates biological activities relation chemical composition, while also considering limitations current studies, lack vivo or clinical trials. literature was sourced from scientific databases, PubMed, Scopus, ScienceDirect, covering research 2010 2024. Future studies should focus optimizing extraction elucidating synergistic bioactivities, conducting in-depth trials validate efficacy safety.

Language: Английский

Citations

0

Optimization of Film-Dressings Containing Herbal Extracts for Wound Care—A Quality by Design Approach DOI Creative Commons
Diana Antonia Safta, Cătălina Bogdan, Sonia Iurian

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 322 - 322

Published: April 25, 2025

Despite the potential of film dressings for wound healing, many formulations lack an optimized design in order to ensure that ingredients were carefully chosen increase product’s efficacy and stability, while also ensuring patient’s comfort during treatment. Moreover, commercially available do not contain herbal extracts or other active substances with healing properties, highlighting a gap market need further research this direction. The aim work was development optimization bio-inspired formulation complex extract-loaded film-dressing be used care, using quality by approach. After setting target product profile critical attributes undergoing risk assessment, experiments implemented. All selected biodegradable, aligning current natural approach, based on their biocompatibility reduced environmental impact. A D-optimal experimental plan used, which types concentrations film-forming agents plasticizers varied: xanthan gum, acacia sodium carboxymethylcellulose glycerol, 1,3-propanediol, xylitol, respectively. contained polyvinyl alcohol previously studied extract. films characterized terms uniformity mass, thickness, swelling degree, folding endurance, adhesive, mechanical properties. achieved maximizing adhesive hardness, deformation at target, elongation break. characterized, vitro total polyphenolic content release from evaluated. Following understanding influences factors characteristics, composition determined as follows: 5% alcohol, 0.25% 10% 20% exhibited high degree (627.28%), properties (adhesive force 28.00 g adhesiveness 0.20 mJ), elasticity (deformation 29.80%, break 106.90%), well good (hardness 2616.00 g), are suitable characteristics use wounds. sustained release, maximum polyphenols 88.00% after 8 h.

Language: Английский

Citations

0

Optimized Sambucus nigra L., Epilobium hirsutum L., and Lythrum salicaria L. Extracts: Biological Effects Supporting Their Potential in Wound Care DOI Creative Commons
Diana Antonia Safta, Ana-Maria Vlase, Anca Pop

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 521 - 521

Published: April 27, 2025

This study aimed to optimize the extraction of phytocompounds intended for wound care applications from three plant species, Sambucus nigra L. flowers and Epilobium hirsutum Lythrum salicaria aerial parts, by using a Quality Design approach. The effects different methods (ultra-turrax ultrasonic-assisted extraction), ethanol concentrations (30%, 50%, 70%), times (3, 5, 10 min) were studied, during optimization step, polyphenol flavonoid contents maximized. phytochemical profiles optimized HEs (herbal extracts) assessed LC-MS/MS methods. antioxidant capacity was determined DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity) TEAC (Trolox equivalent capacity), FRAP (ferric reducing power) assays, while antibacterial activity evaluated against Escherichia coli, Pseudomonas aeruginosa, MSSA—methicillin-sensitive Staphylococcus aureus MRSA—methicillin-resistant aureus). Cell viability healing potential on keratinocytes fibroblasts. anti-inflammatory effect fibroblasts measuring levels interleukins IL-6 IL-8 production nitric oxide RAW 264.7 cells. major compounds rutin chlorogenic acid. HE showed strongest activity, demonstrated high cell viability. increased capacities. All extracts displayed effects, exhibited best in vitro wound-healing effect.

Language: Английский

Citations

0

Anticancer Potential of Tocopherols-Containing Plants and Semi-Synthetic Tocopherols DOI Creative Commons
Nesti Fronika Sianipar, ZIDNI MUFLIKHATI, Dave Mangindaan

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(21), P. 2994 - 2994

Published: Oct. 26, 2024

Tocopherols, potent bioactive compounds with anticancer properties, remain understudied in herbal medicinal plants, presenting a significant knowledge gap the field of natural agents. This review evaluates tocopherol-containing plants for their potential, analyzing Scopus publications from 2016 to 2024. Fifteen were identified as promising candidates, including Bulbine anguistifolia Poelln, Punica granatum L., Moringa oleifera, Kigelia pinnata, and Typhonium flagelliforme Lodd. The explores tocopherols’ mechanisms, apoptosis induction cell cycle arrest. Factors influencing effects are examined, such forms (α, β, γ, δ), concentrations, plant parts utilized, stability various plants. Additionally, emerging research on semi-synthetic tocopherol derivatives is analyzed, highlighting potential adjuvants chemotherapy role enhancing drug delivery reducing side effects. comprehensive analysis aims advance development plant-based pharmaceuticals improve cancer treatment strategies. By elucidating mechanisms this provides foundation future therapies. It emphasizes need further investigation into these plants’ potentially leading novel, more effective, less toxic findings presented here contribute nuanced understanding how can be leveraged drugs.

Language: Английский

Citations

3

Efficacy of Willow Herb (Epilobium angustifolium L. and E. parviflorum Schreb.) Crude and Purified Extracts and Oenothein B Against Prostatic Pathogens DOI Creative Commons
Alexia Barbarossa, Antonio Rosato, Alessia Carocci

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 117 - 117

Published: Jan. 23, 2025

Background/Objectives: Plants species of the Epilobium genus are traditionally used to treat prostatitis and other urinary tract disorders particularly rich in ellagitannins flavonol 3-O-glycosides. The aim this work was evaluate inhibitory activity different extracts from E. angustifolium L. parviflorum Schreb. their major bioactive compound, oenothein B, against a panel Gram-positive (Enterococcus faecalis ATCC 29212, Enterococcus BS, Staphylococcus aureus 25923, 29213, 43300) Gram-negative (Escherichia coli 25922, Escherichia 35218, Klebsiella pneumoniae 13883, 70063, Proteus mirabilis Pseudomonas aeruginosa 27853) bacteria responsible for prostatitis. Methods: Aqueous ethanolic raw were prepared, latter further purified using resin AmberliteTM XAD7HP. Then, an HPLC-MS/MS method developed quantification marker bioactives levels correlated with antimicrobial activity. Results: Purified richer polyphenols (330.80 367.66 mg/g dry extract parvifolium, respectively) than extracts. Oenothein B predominant compound all (119.98 327.57 extract). minimum concentrations (MICs) range µg/mL indicated significant antibacterial activity, which higher (MIC values 4 16 8 1024 on strains, respectively). Conclusions: These results outline outstanding potential as therapeutic alternatives or complementary agents conventional antibiotic treatments infections.

Language: Английский

Citations

0

Optimization of phenolic compounds extraction and antioxidant activity from Moroccan Crocus sativus L. by-products using predictive modeling and Box-Behnken design DOI

Chaimae Slimani,

Mouhcine Fadil, Chaïmae Raïs

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113444 - 113444

Published: March 1, 2025

Language: Английский

Citations

0

Biochemical-physiological responses of Reseda lutea , Epilobium dodonaei , and Gentianella ciliata to stress in an open pit of an abandoned iron mine DOI
Adisa Parić, Edina Muratović, Senad Murtić

et al.

International Journal of Phytoremediation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: March 26, 2025

The photosynthetic pigments, antioxidant properties, and heavy metal content in Reseda lutea, Epilobium dodonaei, Gentianella ciliata were examined response to stress the open pit of an abandoned iron mine. soils shallow, alkaline, severely deficient phosphorus, potassium, humus. Heavy concentrations rhizospheres followed order Fe > Mn Pb Zn Cu Ni Cr Cd for all three species, with Cu, Zn, exceeding limits established by Bosnian legislation. results indicated that bioelements within permissible set FAO/WHO. dodonaei acted as a accumulator. highest pigments was observed this species. Positive correlations detected between total phenolics, flavonoids E. phenolic acids G. ciliata. Negative noted R. phenolics dodonaei. Increased proline DPPH associated heightened levels These findings suggest species analyzed employ distinct defense mechanisms, enabling them effectively adapt stress.

Language: Английский

Citations

0

Phytochemical Profile and Biological Activities of Extracts Obtained from Young Shoots of Blackcurrant (Ribes nigrum L.), European Blueberry (Vaccinium myrtillus L.), and Mountain Cranberry (Vaccinium vitis-idaea L.) DOI Creative Commons

Maria-Beatrice Solcan,

Ionel Fizeșan, Laurian Vlase

et al.

Horticulturae, Journal Year: 2023, Volume and Issue: 9(11), P. 1163 - 1163

Published: Oct. 24, 2023

This study explores the bioactive potential of young shoots from blackcurrant, European blueberry, and mountain cranberry, widely employed in gemmotherapy phytotherapy, as rich sources antioxidants, antimicrobial agents, anti-inflammatory components. The primary aims this were to enhance extraction conditions for compounds blackcurrant using Modde software experimental design, conduct a comprehensive phytochemical analysis cranberry shoot extracts through LC–MS analysis, evaluate vitro biological activities these optimized extracts. design comprised multiple variables: techniques, solvent type, time, apparent pH, solvent-to-vegetal product ratio. responses included total phenolic content, flavonoid condensed tannin antioxidant activity determined DPPH assay. Furthermore, was validated cell culture experiments, addition cytotoxicity assessments conducted on both normal cancer lines. Extracts obtained Ultra-Turrax 70% acetone displayed high levels polyphenolic enhanced potential, regardless origin. revealed predominant occurrence chlorogenic acid, hyperoside, isoquercitrin all examined samples. also significant when evaluated These results provide valuable insights into potent components present extracts, paving way further exploration therapeutic applications.

Language: Английский

Citations

9

Chemical Composition and Antioxidant Activity of Six Allium Extracts Using Protein-Based Biomimetic Methods DOI Creative Commons
Ioana Barbu, Vlad Alexandru Toma, Augustin C. Moț

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1182 - 1182

Published: Sept. 29, 2024

Medicinal plants are a valuable reservoir of novel pharmacologically active compounds. ROS and free radicals primary contributors to oxidative stress, condition associated with the onset degenerative diseases such as cancer, coronary heart disease, vascular disease. In this study, we used different spectrophotometry methods demonstrate antioxidant properties 6

Language: Английский

Citations

3

The Antimicrobial Effect of Cornus mas L. and Sorbus aucuparia L. Fruit Extracts against Resistant Uropathogens in Correlation with the Prevalence of Urinary Tract Infections in Companion Animals DOI Creative Commons
Mara Aurori, Cristiana Ştefania Novac, G. Nadăş

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 814 - 814

Published: June 20, 2024

Urinary tract infections (UTIs) are a widespread condition in pets, with many antibiotics being prescribed, contributing to the rise antimicrobial resistance, which is worldwide threat. This study's main objective was analyze vitro activity of

Language: Английский

Citations

2