Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 840 - 840

Published: March 30, 2023

Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis type 2 diabetes mellitus. A long-term increase free fatty acids induces reactive oxygen species (ROS) β-cells, leading to apoptosis and dysfunction β-cells. Ganoderma lucidum spore oil (GLSO) functional food complex with strong antioxidant activity, but its solubility stability are poor. In present study, GLSO-functionalized selenium nanoparticles (GLSO@SeNPs) high uniform particle size were synthesized by high-pressure homogeneous emulsification method. The aim this study was investigate protective effects GLSO@SeNPs on INS-1E rat insulinoma against palmitic-acid (PA)-induced cell death, as well underlying mechanisms. Our results showed that had good biocompatibility, they significantly inhibited PA-induced cells regulating activity related enzymes, including thioredoxin reductase (TrxR), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px). Western blot analysis reversed changes MAPK pathway protein expression levels. Thus, findings provided new theoretical basis for utilizing treatment diabetes.

Language: Английский

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Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells

Plants, Journal Year: 2023, Volume and Issue: 12(9), P. 1919 - 1919

Published: May 8, 2023

Oxidative stress and cellular senescence in dermal papilla cells (DPCs) are major etiological factors causing hair loss. In this study, the effect of Allium hookeri extract (AHE) on hair-inductive anti-oxidative properties was investigated human DPCs. As a result, it found that non-cytotoxic concentration extracts increased viability size DPC spheroid, which associated with expression hair-growth-related genes cells. To determine whether or not these effects could be attributed to intracellular effects, liquid chromatography-mass spectrometry alongside various biochemical analyses conducted herein. An ingredient called alliin identified as one main components. Furthermore, AHE treatment induced significant decrease H2O2-mediated cytotoxicities, cell death, Upon analyzing results molecular mechanism approach, shown β-Catenin NRF2 translocation into nucleus while inhibiting NF-κB (p50) through p38 PKA-mediated phosphorylations GSK3β, an upstream regulator those proteins. These overall indicate possibility can regulate GSK3β-mediated β-Catenin, NRF2, signaling enhance ultimately protect against oxidative stress-induced damage

Language: Английский

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The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

Foods, Journal Year: 2023, Volume and Issue: 12(13), P. 2629 - 2629

Published: July 7, 2023

Skin cancer is a prevalent type of worldwide and has high growth rate compared to other diseases. Although modern targeted therapies have improved the management cutaneous neoplasms, there an urgent requirement for safer, more affordable, effective chemoprevention treatment strategy skin cancer. Nutraceuticals, which are natural substances derived from food, emerged as potential alternative or adjunctive option. In this review, we explore current evidence on use omega-3 fatty acids polyphenols (curcumin, epigallocatechin gallate, apigenin, resveratrol, genistein) melanoma non-melanoma (NMSC), well in their prevention. We discuss mechanisms action aforementioned nutraceuticals probable therapeutic benefits Omega-3 acids, curcumin, genistein several properties, among anti-inflammatory anti-tumor, can help prevent treat However, effectiveness limited due poor bioavailability. Nanoparticles delivery systems improve absorption targeting. More research needed evaluate safety approach prevention treatment. These compounds should not replace conventional treatments, but may be used complementary therapy under guidance healthcare professional.

Language: Английский

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Role of neurogenic inflammation in the pathogenesis of alopecia areata

The Journal of Dermatology, Journal Year: 2024, Volume and Issue: 51(5), P. 621 - 631

Published: April 11, 2024

Abstract Alopecia areata refers to an autoimmune illness indicated by persistent inflammation. The key requirement for alopecia occurrence is the disruption of immune‐privileged regions within hair follicles. Recent research has that neuropeptides play a role in damage follicles triggering neurogenic inflammation, stimulating mast cells ambient follicles, and promoting apoptotic processes keratinocytes. However, exact pathogenesis requires further investigation. Recently, there been increasing focus on understanding mechanisms immune diseases resulting from interplay between nervous system. Neurogenic inflammation due neuroimmune disorders skin system may disrupt inflammatory microenvironment follicle, which plays crucial part progression areata.

Language: Английский

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Genetic association between asthma and alopecia areata: A two‐sample Mendelian randomization study

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Many patients with asthma experience alopecia areata (AA) in their lives. However, it is unclear whether causes or results from AA. Our objective was to investigate the genetic causal relationship between and

Language: Английский

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Gut microbiome, metabolome and alopecia areata

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 15, 2023

Alopecia areata (AA) is a type of dermatological disease characterized by rapid and non-scarring hair loss the scalp or body skin that may be related to genetic, immunological physiological factors. It now believed AA associated with oxidative stress, autoimmune disease, neuropsychological factors, pathogens, immune checkpoint inhibitors microecological imbalance under premise host genetic susceptibility. In recent years, studies have revealed significant role gut microbiome metabolome in many aspects human health. Diverse an important influence on conditions. This review highlights relationship between provide novel directions for prevention, clinical diagnosis treatment AA.

Language: Английский

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Age-Related Variations in the Population of Active Secondary Hair Follicles, Oxidative Stress and Antioxidant Parameters in Cashmere Goats

Published: April 11, 2024

The objective of this study was to investigate age-related changes in cashmere production and the population active secondary hair follicles goats across different age groups, as well explore association between follicle activity oxidative stress. A total 104 adult Inner Mongolian ewe goats, aged 2 7 years old, were randomly selected experimental subjects. Skin samples collected August 2020 April 2021. fiber yield, staple length, diameter showed variations (P < 0.05). Cashmere higher 2-4 compared those 5-7 There no significant differences primary among years. However, varied significantly with age, younger group (aged years) having a than 5 – moderate negative correlation observed Age-related skin antioxidant capacity damage old Goats 4 exhibited lower Interestingly, positive correlations, respectively, This presents novel approach enhance improve performance through regulation

Language: Английский

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Autophagy Dysfunction: The Kernel of Hair Loss?

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 1165 - 1181

Published: May 1, 2024

Autophagy is recognized as a crucial regulatory process, instrumental in the removal of senescent, dysfunctional, and damaged cells. Within autophagic lysosomal digestion plays critical role elimination impaired organelles, thus preserving fundamental cellular metabolic functions various biological processes. Mitophagy, targeted process that specifically focuses on mitochondria, essential for sustaining health energy balance. Therefore, deep comprehension operational mechanisms implications autophagy mitophagy vital disease prevention treatment. In this context, we examine during hair follicle cycles, closely scrutinizing their potential association with loss. We also conduct thorough review behind mitophagy, highlighting interaction stem cells dermal papilla conclusion, investigate manipulating pathways to develop innovative therapeutic strategies

Language: Английский

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Unraveling Ritlecitinib: an in-depth analysis of JAK3 inhibitor for the treatment of alopecia areata

Expert Opinion on Drug Metabolism & Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Sept. 9, 2024

Alopecia Areata (AA), characterized by non-scarring hair loss due to the dysregulation of JAK/STAT pathway, has long lacked effective treatment. In 2023, Ritlecitinib, a novel Janus kinase (JAK) 3 and tyrosine family inhibitor, received its first approval from US FDA treat AA, followed approvals in Japan, Europe, China, UK. This development aims address challenges faced millions individuals affected this condition globally.

Language: Английский

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Synergistic Phytochemical and Pharmacological Actions of Hair RiseTM Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation

Plants, Journal Year: 2024, Volume and Issue: 13(19), P. 2802 - 2802

Published: Oct. 6, 2024

Androgenetic alopecia (AGA) is a genetic condition characterized by an excessive response to androgens, leading hairline regression in men and hair thinning at the vertex women, which can negatively impact self-esteem. Conventional synthetic treatments for AGA are often limited their side effects. In contrast, Thai medicinal plants offer promising alternative with fewer adverse This study investigates synergistic phytochemical pharmacological effects of novel Hair Rise

Language: Английский

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