A review on selenium nanoparticles and their biomedical applications

Biomedical Technology, Journal Year: 2023, Volume and Issue: 6, P. 61 - 74

Published: Dec. 29, 2023

Nanotechnology has enormous promise for a wide range of applications in biology. Nanoparticles (NPs) have the benefit improving bioactivity, decreasing toxicity, allowing precision targeting, and modulating release profile encapsulated compounds. Nanomaterials' unique qualities, such as their tiny size, biocompatibility, ability to cross cell membranes drug administration, make them useful variety biological applications. Selenium (Se), critical trace element, stands out among these nanoparticles due its specific bioactivities nano forms. is incorporated into Selenoproteins selenocysteine (Sec), which play an important role maintaining physiological redox balance via oxidoreductase activity, enzymatic process. In field medication delivery, selenium-based devices been designed transport pharmaceuticals locations. (SeNPs) appear be suitable platform delivering medications desired sites. Selenium's medicinal potential thoroughly investigated, including efficacy against various cancer cells, microbial pathogens, viral infections, neuroprotective properties, diabetic control, oxidative stress, inflammation-mediated illnesses rheumatoid arthritis. Notably, selenium's extraordinary involvement immune system regulation, SeNPs edge over other nanoparticles. phytosynthesis offers appealing alternative standard physical chemical processes, featuring biocompatibility environmental friendliness. This paper gives overview SeNPs' uses emphasizes recent advances field.

Language: Английский

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Unveiling the Ameliorative Effects of Phyto-selenium Nanoparticles (PSeNPs) on Anti-hyperglycemic Activity and Hyperglycemia Irradiated Complications

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 10, 2025

Language: Английский

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Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Glucagon-like peptide-1 receptor (GLP-1R) is a well-established target for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The development orally bioavailable long-acting small-molecule GLP-1R agonists pursuit in both academia industry. Herein, new selenium (Se)-containing compounds were designed using Se-oxygen bioisostere strategy on danuglipron scaffold. Among these, compound 21 was exhibited full agonistic efficacy promoting cyclic adenosine monophosphate (cAMP) accumulation. In hGLP-1R knock-in mice, effectively reduced blood glucose levels food intake, with duration action slightly extended compared to that danuglipron. Importantly, no significant adverse effects observed mice treated during subacute toxicity studies. This study delineates potential Se-containing as agonists, emerging promising candidate T2DM obesity treatment.

Language: Английский

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A Comparative Study of Nanoconjugates of a Synthetic and a Natural Drug Against T2DM-Induced Cognitive Dysfunction

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 1, 2025

Language: Английский

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Synthesis, Characterization, and Cytotoxic Evaluation of Selenium Nanoparticles

Biomedical & Pharmacology Journal, Journal Year: 2025, Volume and Issue: 18(1), P. 909 - 919

Published: March 31, 2025

Studies on the functional characteristics of Se nanoparticles (SeNP) have become increasingly popular in recent decades because their strong selectivity, stability, and high biocompatibility. Numerous studies demonstrate SeNP's anticarcinogenic properties. In order to defeat bacteria that are resistant antibiotics, new strategies need be developed. A subclass antimicrobial peptides known as selenium (NPs) can used either place or addition well-known antibiotics. SeNPs been investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential, transmission electron microscopy (TEM)., UV-visible analysis. The antibacterial qualities were confirmed by generated showed increased activity at different concertation (1000-64) µg/ml good diffusion assay, NPs efficiently suppressed growth susceptible zones inhibition between 5-19 mm against Gram-Negative while Gram Positive Staphylococcus epidermidis aureus 6-17 , respectively. Our study has shown combining various antimicrobials mechanisms action led an extensive variety raised efficacy, particularly germs several medications. best anti- human breast cancer cell line MCF7 properties nanocomposite above lines was case line. According findings, may administrated for treatment types humans. Ovarian had nanoparticle sensitivity. At a concentration 25 μL/mL, demonstrated excellent cytotoxicity anticancer activity, making them suitable use agent.The physicochemical characteristics, experimental setup, concentrations exploited this must all carefully stated.

Language: Английский

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Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Negative energy balance (NEB) typically occurs in dairy cows after delivery. Cows with a high yield are more likely to experience significant NEB. This type of metabolic imbalance could cause ketosis, which is often accompanied by decline reproductive performance. However, the molecular mechanisms underlying NEB have yet be fully elucidated. During excessive NEB, body fat extensively broken down, resulting abnormal accumulation non-esterified fatty acids (NEFAs), represented palmitic acid (PA), within uterus. Such an has potential damage bovine endometrial epithelial cells (BEECs), while its involvement PA-induced injury BEECs remains poorly understood. Melatonin (MT) recognized for regulatory role maintaining homeostasis mitochondrial reactive oxygen species (mitoROS). little known as whether MT ameliorate incurred response PA and mechanism involved.

Language: Английский

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Melatonin alleviates palmitic acid–induced mitochondrial dysfunction by decreasing oxidative stress and enhancing autophagy combined in bovine endometrial epithelial cells

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Background: Negative energy balance (NEB) typically occurs in dairy cows after delivery, with those high yielding being more likely to experience significant NEB. Such metabolic imbalance could cause ketosis, which is often accompanied by a decline reproductive performance, but the molecular mechanism has not been fully elucidated. During excessive NEB, body fat extensively broken down, resulting abnormal accumulation of non-esterified fatty acids (NEFA), represented palmitic acid (PA), within uterus. an potential damage bovine endometrial epithelial cells (BEECs), while mechanisms underlying its involvement PA-induced injury BEECs poorly understood. Melatonin (MT) recognized for regulatory role maintaining homeostasis mitochondrial reactive oxygen species (mitoROS). However, less known about whether MT ameliorate PA on and mechanism. Results: Our results demonstrated that 0.2 mM stress increased level cellular oxidative stress. Further, we observed dysfunction, including incidence structure respiratory function, reduction membrane copy number, turn induced apoptosis. Notably, also found upregulation autophagy protein (PINK, Parkin, LC3B et al), however, P62 was increased. As expected, 100uM pre-treatment attenuated ROS restored function. Meanwhile, pre-treated reversed activate AMPK-mTOR-Beclin-1 pathway, contributing increase Conclusions: These findings indicate induce dysfunction enhance BEECs. In addition, hypothesized only reduce facilitate clearance damaged mitochondria through regulation pathways, thereby safeguarding pool promoting viability. study helps better understand involved NEB's impact fertility outcomes cows.

Language: Английский

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Biotechnological potential of Ganoderma species: current progress and future prospects

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60

Published: Aug. 22, 2024

Ganoderma, a genus deeply rooted in traditional medicinal practices across diverse Asian cultures throughout history, has garnered renewed attention due to its promising biotechnological potential, particularly health-enhancing properties. The distinctive characteristics exhibited by various species within the Ganoderma render them invaluable for wide spectrum of applications both industrial and pharmaceutical contexts. Recent advancements research have unveiled plethora captivating opportunities which plays pivotal role. These encompass range applications, including but not limited enzyme production, extraction bioactive compounds, bioremediation, bioprospecting, biodegradation. involvement these areas highlights versatility significance contributing multiple sectors. This comprehensive review explores vistas offering insights into multifaceted potential impact applications. By elucidating biotechnology, this aims underscore role contemporary innovation. Furthermore, through deeper exploration potentials seeks highlight contributions implications future biotechnology sustainability.

Language: Английский

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Molecular networking and Paterno-Büchi reaction guided glycerides characterization and antioxidant activity assessment of Ganoderma lucidum spore oil

Food Chemistry, Journal Year: 2024, Volume and Issue: 468, P. 142500 - 142500

Published: Dec. 15, 2024

Language: Английский

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