Therapeutic Activity of Green Tea Epigallocatechin-3-Gallate on Metabolic Diseases and Non-Alcoholic Fatty Liver Diseases: The Current Updates

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 3022 - 3022

Published: July 3, 2023

Green tea polyphenols have numerous functions including antioxidation and modulation of various cellular proteins are thus beneficial against metabolic diseases obesity, type 2 diabetes, cardiovascular non-alcoholic fatty liver diseases, their comorbidities. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green attributed to antioxidant free radical scavenging activities, likelihood targeting multiple pathways. It has been shown exhibit anti-obesity, anti-inflammatory, anti-diabetic, anti-arteriosclerotic, weight-reducing effects humans. Worldwide, incidences escalating across all age groups modern society. Therefore, EGCG being increasingly investigated address problems. This review presents current updates on highlights evidence related its safety. Collectively, this brings more for therapeutic application further studies derivatives alleviate diseases.

Language: Английский

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Anti-Inflammatory Effect of Ebractenoid F, a Major Active Compound of Euphorbia ebracteolata Hayata, through Inhibition of Nuclear Factor-κB Activation

Plants, Journal Year: 2023, Volume and Issue: 12(15), P. 2845 - 2845

Published: Aug. 1, 2023

Euphorbia ebracteolata Hayata (Euphorbiaceae family) is a perennial plant that widely distributed in Korea, Japan, and China. Its roots contain bioactive diterpenes have anti-inflammatory properties. However, the mechanisms are not yet fully understood. This study aimed to identify most active compound from of E. Hayata, using bioassay-guided fractionation combinative method high-speed countercurrent chromatography (HSCCC) preparative high-performance liquid (HPLC). Then, we investigated its mechanism lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Ebractenoid F was identified as potent Hayata. significantly decreased nitric oxide (NO) production nuclear factor-κB (NF-κB) activation induced by LPS Moreover, ebractenoid degradation inhibitory κB-α, translocation p65 p50 subunits NF-κB, expression NF-κB downstream genes. Furthermore, inhibited phosphorylation Akt mitogen-activated protein kinases (MAPKs), such extracellular signal-regulated kinase (ERK) c-Jun NH2 terminal (JNK), LPS-stimulated cells. In conclusion, exerts effect suppressing NF-κB-mediated NO may be useful therapeutic for prevention or treatment inflammation-associated diseases.

Language: Английский

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L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 665 - 665

Published: Feb. 13, 2025

This narrative review provides an analysis of the role nitric oxide (NO) and its precursors, particularly L-arginine, in vascular regulation health, with emphasis on findings from our experimental research animal models. NO serves as a critical mediator function, contributing to vasodilation, blood flow, prevention thrombosis. As primary precursor NO, L-arginine is essential for maintaining endothelial integrity, modulating mitochondrial reducing oxidative damage. synthesises data contextualises these within physiological challenges faced by donors, such repeated donation associated stress. It examines effects supplementation respiration, lipid peroxidation, microsomal oxidation different conditions, including differences age, gender, dietary interventions. The mechanisms which enhances production, improves elasticity, alleviates dysfunction caused reduced bioavailability are also investigated. By integrating insights existing literature, this perspective potential address specific needs donors. highlights importance personalised nutritional approaches enhancing donor recovery resilience. In addition, assesses wider implications mitigating stress preserving function. interplay between bioavailability, factors, adaptation donors highlighted, along identification current knowledge gaps recommendations future research. presenting both original evidence synthesis article therapeutic promoting health context donation.

Language: Английский

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Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122423 - 122423

Published: Dec. 16, 2023

Language: Английский

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Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(12), P. 5227 - 5237

Published: Aug. 6, 2024

ABSTRACT Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, skin contact. Exposure HgCl can cause severe health effects, including damages the gastrointestinal, respiratory, central nervous systems. The purpose of this work was explore if carvacrol (CRV) protect rats lungs from damage caused by . Intraperitoneal injections at a dose 1.23 mg/kg body weight were given either alone or in conjunction with oral CRV administration doses 25 50 for 7 days. study included biochemical histological techniques examine lung tissue's oxidative stress, apoptosis, inflammation, autophagy processes. ‐induced reductions GSH levels antioxidant enzymes (SOD, CAT, GPx) activity enhanced co‐administration. Furthermore, MDA lowered CRV. inflammatory mediators NF‐κB, IκB, NLRP3, TNF‐α, IL‐1β, IL6, COX‐2, iNOS all reduced When exposed , apoptotic Bax, caspase‐3, Apaf1, p53, caspase‐6, caspase‐9 increased, but antiapoptotic Bcl‐2 after treatment. decreased Beclin‐1, LC3A, LC3B, which turn damage. After treatment, higher pathological observed terms alveolar septal thickening, congestion, edema, cell infiltration compared control group while ameliorated these effects. Consequently, preventing increases stress corresponding autophagy, disturbance tissue integrity tissues, might seen as useful therapeutic alternative.

Language: Английский

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Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Potential Anti-ulcerogenic Effect of Troxerutin in Ethanol-induced Gastric Lesions in Mice: Anti-inflammatory and Antioxidant Mechanisms and Possible Action Pathways

Revista Brasileira de Farmacognosia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Sport: Improving exercise performance with polyphenol extracts

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 149 - 176

Published: Jan. 1, 2025

Language: Английский

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Polyphenols: Potential Applications in Cancer Therapy

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

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L-Arginine and Immune Modulation: A Pharmacological Perspective on Inflammation and Autoimmune Disorders

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177615 - 177615

Published: April 1, 2025

Language: Английский

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