Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 22, 2023
Abstract
Acute
myeloid
leukemia
(AML)
is
a
disease
of
malignant
proliferation
abnormally
or
poorly
differentiated
cells
the
hematopoietic
system.
The
clinical
treatments
non-M3
AML
are
experiencing
lack
effective
drugs.
V8
newly
synthesized
derivative
natural
flavonoid
wogonin,
which
belongs
to
potential
anticancer
drug,
and
has
shown
significant
antitumor
activity
in
vitro
vivo
.
In
this
study,
we
investigated
effects
on
cell
lines
primary
underlying
mechanisms.
results
showed
that
inhibited
growth
induced
apoptosis
(ME-1,
Kasumi-1,
U937)
concentration-dependent
manner.
Meanwhile,
revealed
V8-induced
was
accompanied
by
mitochondrial
injury,
such
as
reduction
membrane
ATP
production,
activation
endoplasmic
reticulum
stress
(ERS)
characterized
GRP78
caspase-12
expression
upregulation.
Mechanism
studies
have
injury
mitophagy
via
elevating
intracellular
ROS
level.
addition,
activated
PERK-p-eIF2α-ATF4
Ire1α-XBP1
pathways
selectively
activating
CHOP.
Correspondingly,
degree
apoptosis-related
proteins
were
alleviated
after
elimination
cytoplasmic
with
N-Acetyl-L-cysteine
(NAC)
knocking
out
CHOP
transfection
shRNA,
implicating
injury-triggered
upregulation
played
an
important
role
cells.
cells-bearing
NOD/SCID
mice
model
U937
cells-inoculating
BALB/c
nude
xenografts
transplantation
tumor
model,
administration
markedly
prolonged
survival
time
CHOP-mediated
ERS
conclusion,
our
study
provides
new
insight
into
mechanism
apoptosis,
suggesting
promising
agent
against
AML.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(15), P. 2224 - 2224
Published: July 31, 2023
Over
the
last
ten
years,
there
has
been
a
growing
interest
in
metal–organic
frameworks
(MOFs),
which
are
unique
category
of
porous
materials
that
combine
organic
and
inorganic
components.
MOFs
have
garnered
significant
attention
due
to
their
highly
favorable
characteristics,
such
as
environmentally
friendly
nature,
enhanced
surface
area
pore
volume,
hierarchical
arrangements,
adjustable
properties,
well
versatile
applications
fields
chemical
engineering,
science,
environmental
biomedical
sectors.
This
article
centers
on
examining
advancements
using
for
remediation
purposes.
Additionally,
it
discusses
latest
developments
employing
potential
tools
disease
diagnosis
drug
delivery
across
various
ailments,
including
cancer,
diabetes,
neurological
disorders,
ocular
diseases.
Firstly,
concise
overview
MOF
evolution
synthetic
techniques
employed
creating
provided,
presenting
advantages
limitations.
Subsequently,
challenges,
avenues,
perspectives
future
utilization
respective
application
domains
addressed.
Lastly,
comprehensive
comparison
presently
these
is
conducted.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
73, P. 103208 - 103208
Published: May 24, 2024
Recently,
numerous
studies
have
reported
the
interaction
between
senescence
and
oxidative
stress
in
cancer.
However,
there
is
a
lack
of
comprehensive
understanding
precise
mechanisms
involved.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(3), P. 153 - 153
Published: March 1, 2024
The
rehabilitation
of
alveolar
bone
defects
moderate
to
severe
size
is
often
challenging.
Currently,
the
therapeutic
approaches
used
include,
among
others,
guided
regeneration
technique
combined
with
various
grafts.
Although
these
techniques
are
widely
applied,
several
limitations
and
complications
have
been
reported
such
as
morbidity,
suboptimal
graft/membrane
resorption
rate,
low
structural
integrity,
dimensional
stability.
Thus,
development
biomimetic
scaffolds
tailor-made
characteristics
that
can
modulate
cell
tissue
interaction
may
be
a
promising
tool.
This
article
presents
critical
consideration
in
scaffold’s
design
while
also
providing
information
on
fabrication
methods
nanosystems.
Their
utilization
delivery
systems
will
mentioned.
Crystals,
Journal Year:
2023,
Volume and Issue:
13(8), P. 1236 - 1236
Published: Aug. 10, 2023
This
review
study
aims
to
present,
in
a
condensed
manner,
the
significance
of
use
crystalline
carbon-based
nanomaterials
biomedical
applications.
Crystalline
nanomaterials,
encompassing
graphene,
graphene
oxide,
reduced
carbon
nanotubes,
and
quantum
dots,
have
emerged
as
promising
materials
for
development
medical
devices
various
These
possess
inorganic
semiconducting
attributes
combined
with
organic
π-π
stacking
features,
allowing
them
efficiently
interact
biomolecules
present
enhanced
light
responses.
By
harnessing
these
unique
properties,
offer
opportunities
future
advancements
biomedicine.
Recent
studies
focused
on
targeted
drug
delivery,
cancer
treatment,
biosensors.
The
conjugation
modification
led
significant
plethora
therapies
addressed
limitations
preclinical
Furthermore,
wide-ranging
therapeutic
advantages
nanotubes
been
thoroughly
examined
context
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2244 - 2244
Published: July 12, 2024
Aging
is
the
most
prominent
risk
factor
for
neurodegeneration
occurrence.
The
common
neurodegenerative
diseases
(NDs),
Alzheimer’s
(AD)
and
Parkinson’s
(PD)
diseases,
are
characterized
by
incidence
of
proteinopathy,
abnormal
activation
glial
cells,
oxidative
stress,
neuroinflammation,
impaired
autophagy
cellular
senescence
excessive
patient’s
age.
Moreover,
mitochondrial
disfunction,
epigenetic
alterations
neurogenesis
inhibition,
together
with
increased
blood–brain
barrier
permeability
gut
dysbiosis,
have
been
linked
to
ND
pathogenesis.
Since
NDs
still
lack
curative
treatment,
recent
research
has
sought
therapeutic
options
in
restoring
microbiota
supplementing
probiotic
bacteria-derived
metabolites
beneficial
action
host—so
called
postbiotics.
current
review
focuses
on
literature
explaining
mechanisms
involved
pathogenesis
addressing
impact
that
postbiotics
as
a
whole
mixture
particular
metabolites,
such
short-chain
fatty
acids
(SCFAs),
lactate,
polyamines,
polyphenols,
tryptophan
exopolysaccharides
bacterial
extracellular
vesicles,
ageing-associated
processes
underlying
also
discusses
issue
implementing
into
prophylaxis
therapy,
depicting
them
compounds
senescence-triggered
dysfunctions
worth
translating
from
bench
pharmaceutical
market
response
“silver
consumers”
demands.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 115 - 115
Published: Jan. 20, 2025
The
role
of
mitochondria
as
the
electric
engine
cells
is
well
established.
Over
past
two
decades,
accumulating
evidence
has
pointed
out
that,
despite
presence
a
highly
active
glycolytic
pathway
(Warburg
effect),
functional
and
even
upregulated
mitochondrial
respiration
occurs
in
cancer
to
meet
need
high
energy
biosynthetic
demand
sustain
their
anabolic
growth.
Mitochondria
are
also
primary
source
intracellular
ROS.
Cancer
maintain
moderate
levels
ROS
promote
tumorigenesis,
metastasis,
drug
resistance;
indeed,
once
cytotoxicity
threshold
exceeded,
trigger
oxidative
damage,
ultimately
leading
cell
death.
Based
on
this,
metabolic
functions
generation
considered
attractive
targets
synthetic
natural
anticancer
compounds.
Tocotrienols
(TTs),
specifically
δ-
γ-TT
isoforms,
vitamin
E-derived
biomolecules
widely
shown
possess
striking
properties
since
they
regulate
several
molecular
pathways.
Herein,
we
provide
for
first
time
an
overview
reprogramming
redox
homeostasis
perturbation
occurring
cells,
highlighting
involvement
TTs.
This
sheds
light
use
these
compounds
promising
preventive
or
therapeutic
approach
novel
strategies.
Livers,
Journal Year:
2025,
Volume and Issue:
5(2), P. 15 - 15
Published: March 28, 2025
The
pathogenesis
of
primary
biliary
cholangitis
(PBC)
is
not
fully
understood.
Despite
recent
progress,
many
aspects
require
further
clarification.
Thus,
PBC
regarded
as
an
autoimmune
disease,
but
immunosuppressive
treatment,
which
effective
in
other
diseases,
working
the
case
PBC.
Moreover,
there
are
controversies
over
pathogenetic
role
anti-mitochondrial
antibodies
mitochondria
present
all
cells
only
cholangiocytes
damaged.
In
this
review,
proposed
models
and
factors
that
have
been
involved
presented.
They
include
mechanisms
such
dysregulated
autophagy,
senescence,
apoptosis,
impairment
protective
bicarbonate
umbrella,
immunological
abnormalities,
dysbiosis
gut
microbiota,
bile
acids.
Genetics
epigenetic
transcriptional
modifications
also
Data
supporting
molecular
mimicry
viral
etiology
analyzed.
Finally,
integrated
model
based
on
interactions
may
participate
pathogenesis.
Therefore,
purpose
review
to
provide
a
unifying
presentation
various
pathophysiology,
will
allow
for
better
understanding
multifaceted
disease.
New
treatment
targets
be
identified
holistic
model.
