Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156846 - 156846
Published: May 1, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: June 11, 2024
Background The Oxidative Balance Score (OBS), which quantifies the balance between antioxidants and pro-oxidants influenced by diet lifestyle, is crucial given oxidative stress’s significant role in Chronic Kidney Disease (CKD). This study aims to determine association OBS CKD using data from National Health Nutrition Examination Survey (NHANES) 1999-2018. Methods We analyzed spanning 1999 2018. was constructed a detailed array of 20 factors, including dietary nutrients lifestyle behaviors. relationship risk evaluated weighted logistic regression models, adjusted for potential confounders, with generalized additive model (GAM) examining non-linear associations. Subgroup analyses interaction effects across diverse demographic clinical groups, along sensitivity analyses, were performed validate findings. Results Among 32,120 participants analyzed, 4,786 identified CKD. Fully analysis revealed that each unit increase associated 2% reduction prevalence [OR: 0.98 (0.98–0.99), P < 0.001]. Higher quartiles significantly correlated decreased [Q4 vs . Q1: OR: 0.82 (0.68–0.98), = 0.03; trend 0.01]. GAM smoothed curve fit indicated linear Stratified further substantiated inverse prevalence. Conclusions Our findings NHANES affirm U.S. population, underscoring optimizing factors managing risk. These results advocate incorporating considerations into prevention treatment strategies.
Language: Английский
Citations
11
Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1413 - 1413
Published: Aug. 24, 2024
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer's disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form soluble (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by produces active IL-1β, pores cell death (pyroptosis). In accord, countered injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces inflammation, improves repair following injury. inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.
Language: Английский
Citations
10
Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)
Published: March 22, 2025
Abstract Klotho, initially introduced as an anti-aging protein, is expressed in the brain, pancreas, and most prominently kidney. The two forms of Klotho (membrane-bound soluble form) have diverse pharmacological functions such anti-inflammatory, anti-oxidative, anti-fibrotic, tumour-suppressive etc. membrane-bound form plays a pivotal role maintaining kidney homeostasis by regulating fibroblast growth factor 23 (FGF 23) signalling, vitamin D metabolism phosphate balance. deficiency has been linked with significantly reduced protection against various pathological phenotypes, including diabetic disease (DKD), which major cause chronic leading to end-stage disease. Owing pleiotropic actions klotho, it shown beneficial effects DKD tackling complex pathophysiology reducing inflammation, oxidative stress, well fibrosis. Moreover, protective effect klotho extends beyond other conditions, cardiovascular diseases, alzheimer's disease, cancer, inflammatory bowel liver Therefore, this review summarizes relationship between expression diseases special emphasis on DKD, distinct mechanisms potential exogenous supplementation therapeutic strategy. Future research into could unravel novel treatment avenues for diseases.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Acute kidney injury (AKI) is the sudden decrease in renal function that can be attributed to dysregulated reactive oxygen species (ROS) production and impaired mitochondrial function. Irisin, a type I membrane protein secreted by skeletal muscles response physical activity, has been reported alleviate damage through regulation of biogenesis oxidative metabolism. In this study, macrophage membrane-coated metal-organic framework (MCM@MOF) developed as nanocarrier for encapsulating irisin overcome inherent characteristics irisin, including short circulation time, limited kidney-targeting ability, low permeability. The engineered irisin-mediated biomimetic nanotherapeutics have extended time enhanced targeting capability toward injured kidneys due preservation proteins. irisin-encapsulated effectively mitigate acute ischemia-reperfusion protecting modulating SOD2 levels tubular epithelial cells. present study provides novel insights advance development potential therapeutic approach AKI.
Language: Английский
Citations
8
Plants, Journal Year: 2024, Volume and Issue: 13(4), P. 538 - 538
Published: Feb. 16, 2024
Considering that Sorbus aucuparia fruits have been underutilized despite their tremendous potential, this study aimed to correlate the in vitro antioxidant, antibacterial and cell-protective abilities of fruit extracts derived from Romanian cultivars with phytochemical composition. Therefore, following preparation ethanolic carotenoid extracts, screening was performed using UV–Vis HPLC-DAD-ESI-MS methods. The antioxidant activity analyzed DPPH FRAP tests. As results revealed high contents bioactive compounds (polyphenols 1.11 mg GAE/g DM, flavonoids 430.06 µg QE/g DM carotenoids 95.68 µg/g DM) an important antiradical action (DPPH 24.51 mg/mL 0.016 µM TE/mL), we chose further examine fruits’ biological properties. capacity assessed employing agar well diffusion broth microdilution techniques, displaying intense against MSSA, MRSA Enterococcus faecalis, but also E. coli Pseudomonas aeruginosa. on gentamicin-stressed renal cells, through MTT Annexin V-FITC assays. Importantly, a significant increase viability registered stressed cells extract administration low doses; nevertheless, noticed decline when exposed elevated concentrations, potentially due cumulative actions gentamicin. These findings offer novel light cultivars, as ability cell injury.
Language: Английский
Citations
6
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 415 - 415
Published: March 29, 2024
D-galactose has been widely used as an inducer of cellular senescence and pathophysiological processes related to aging because it induces oxidative stress. On the other hand, consumption antioxidants such curcumin can be effective strategy prevent phenotypes enhanced production reactive oxygen species (ROS), senescence. This study aimed evaluate potential protective effect on stress endoplasmic reticulum induced by treatment in Lilly Laboratories Culture-Porcine Kidney 1 (LLC-PK1) human kidney 2 (HK-2) proximal tubule cell lines from pig human, respectively. For induction, cells were treated with 300 mM for 120 h and, antioxidant, 5 µM 24 subsequently + h. In LLC-PK1 cells, decreased 20% number positive senescence-associated (SA)-β-D-galactosidase staining 25% expression 8-hydroxy-2′-deoxyguanosine (8-OHdG) increased 40% lamin B1 expression. HK-2 60% proliferating nuclear antigen (PCNA, 50% Klotho levels, 175% catalase activity. both lines, this antioxidant ROS (20% decrease 10 HK-2). These data suggest that a moderate D-galactose-induced cells.
Language: Английский
Citations
6
Clinical Immunology, Journal Year: 2024, Volume and Issue: 261, P. 109940 - 109940
Published: Feb. 15, 2024
Language: Английский
Citations
5
npj Aging, Journal Year: 2024, Volume and Issue: 10(1)
Published: Oct. 2, 2024
Language: Английский
Citations
5
Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 354, P. 120429 - 120429
Published: Feb. 21, 2024
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 26, 2024
Abstract To explore the optimal cut-off values of Klotho for predicting all-cause and cardiovascular mortality among chronic kidney disease (CKD) patients. was measured in 40–79-year-old individuals NHANES 2007–2016. A total 2418 patients with stage 1–4 CKD were included. The utilized using receiver operator characteristic (ROC) curves be verified on effects mortality. Restricted cubic splines used to examine relationship between cutpoints as reference. After a mean follow-up period 87.9 months, 535 deaths occurred 188 died disease. Cubic showed that risk increased gradually < 700 pg/ml. ROC revealed are 548.8 pg/ml 660.9 pg/ml, respectively. Compared higher levels Klotho, HRs (95% CIs) 1.52 (1.23, 1.87) 1.58 (1.13, 2.22) lower respectively, multivariate model ( P .0001 = 0.008). Our findings CKD.
Language: Английский
Citations
4