Translational Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 17, 2025
The
microbiota-gut-brain
axis
plays
a
pivotal
role
in
neuropsychiatric
disorders,
particularly
depression.
Escitalopram
(ESC)
is
first-line
antidepressant,
however,
its
regulatory
mechanisms
on
the
treatment
of
depression
remain
unclear.
antidepressant
effects
ESC
were
evaluated
using
forced
swim
test
Wistar-Kyoto
(WKY)
rats,
while
damage
gut
and
brain
regions
was
assessed
through
H&E
staining
immunohistochemistry.
therapeutic
WKY
rats
with
depression-like
behavior
investigated
16S
rRNA
sequencing
microbiota,
serum
untargeted
metabolomics,
hippocampal
proteomics.
Results
indicated
that
intervention
improved
depressive-like
behaviors,
as
evidenced
by
increased
swimming
times
also
restored
intestinal
permeability
tissue
integrity.
Significant
changes
microbiota
composition,
an
increase
Bacteroides
barnesiae,
well
increases
sphingolipid
metabolites
(Sphinganine
1-phosphate,
Sphingosine,
Sphingosine-1-phosphate)
proteins
(Sptlc1,
Enpp5,
Enpp2),
strongly
correlated.
These
robust
correlations
suggest
may
exert
modulating
metabolism
influence
microbiota.
Accordingly,
this
research
elucidates
novel
underlying
efficacy
highlights
importance
mediating
these
effects.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2469 - 2469
Published: Sept. 6, 2023
When
“hijacked”
by
compulsive
behaviors
that
affect
the
reward
and
stress
centers
of
brain,
functional
changes
in
dopamine
circuitry
occur
as
consequence
pathological
brain
adaptation.
As
a
correlate
mental
health,
has
central
role
behavioral
regulation
from
healthy
reward-seeking
to
adaptation
response
adversity.
This
narrative
review
offers
spotlight
view
transition
function,
under
control
dopamine,
progressive
deregulation
this
function
interactions
with
other
circuits,
producing
what
may
be
called
an
anti-reward
state.
How
such
is
linked
specific
health-relevant
then
explained
pandemic-related
adversities
stresses
they
engendered.
The
long
lockdown
periods
where
people
social
isolation
had
rely
on
drink,
food,
digital
rewards
via
internet
seen
major
triggers
motivation
behavior
worldwide.
dopamine-mediated
discussed.
It
argued
that,
when
pushed
fate
circumstance
into
physiological
state
anti-reward,
human
health
affected,
depending
individual
vulnerabilities.
A
unified
conceptual
account
places
at
centre
current
global
context
proposed.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(5), P. 389 - 389
Published: Feb. 20, 2024
Disordered
reactive
oxygen/nitrogen
species
are
a
common
occurrence
in
various
diseases,
which
usually
cause
cellular
oxidative
damage
and
inflammation.
Despite
the
wide
range
of
applications
for
biomimetic
nanoparticles
with
antioxidant
or
anti-inflammatory
properties,
designs
that
seamlessly
integrate
these
two
abilities
synergistic
effect
simple
manner
seldom
reported.
In
this
study,
we
developed
novel
PEI-Mn
composite
nanoparticle
(PM
NP)
using
chelation
method,
curcumin
was
loaded
onto
PM
NPs
via
metal–phenol
coordination
to
form
PEI-Mn@curcumin
(PMC
NPs).
PMC
possessed
excellent
dispersibility
cytocompatibility,
engineered
serve
as
an
effective
nanozyme,
exhibited
specific
SOD-like
CAT-like
activities.
addition,
incorporation
granted
ability
effectively
suppress
expression
inflammatory
cytokines
microglia
induced
by
LPS.
As
also
has
it
further
amplified
efficiency
ROS
scavenging.
Significantly,
scavenged
triggered
H2O2
SIM-A9
cells
Neuro-2a
cells.
considerably
mitigated
DNA
lipid
oxidation
demonstrated
increase
cell
viability
under
concentrations.
These
properties
suggest
have
significant
potential
addressing
excessive
inflammation
related
neural
diseases.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1508 - 1508
Published: Dec. 10, 2024
Healthcare
professionals
frequently
experience
significant
work
overload,
which
often
leads
to
substantial
physical
and
psychological
stress.
This
stress
is
closely
linked
increased
oxidative
a
corresponding
decline
in
energy
levels.
scoping
review
investigates
the
potential
impact
of
dietary
antioxidants
food
supplements
conjunction
with
diet
controlling
these
negative
effects.
Through
an
analysis
biochemical
pathways
involved
metabolism,
paper
emphasizes
effectiveness
targeted
interventions.
Key
antioxidants,
such
as
vitamins
C
E,
polyphenols,
carotenoids,
are
evaluated
for
their
ability
counteract
enhance
Additionally,
assesses
various
supplements,
including
omega-3
fatty
acids,
coenzyme
Q10,
ginseng,
mechanisms
action
enhancement.
Practical
guidelines
incorporating
energy-boost
strategies
into
routine
healthcare
provided,
emphasizing
importance
modifications
reducing
improving
overall
well-being
performance
high-stress
environments.
The
concludes
by
suggesting
directions
future
research
validate
findings
explore
new
interventions
that
may
further
support
under
overload.
Biomedical Reports,
Journal Year:
2025,
Volume and Issue:
22(3)
Published: Jan. 14, 2025
Depression
and
coronary
heart
disease
(CHD)
are
two
interconnected
diseases
that
profoundly
impact
global
health.
is
both
a
complex
psychiatric
disorder
an
established
risk
factor
for
CHD.
Sirtuin
1
(SIRT1)
enzyme
requires
the
cofactor
nicotinamide
adenine
dinucleotide
(NAD+)
to
perform
its
deacetylation
function,
involvement
crucial
in
reducing
cardiovascular
risks
associated
with
depression.
SIRT1
exerts
cardioprotective
effects
via
modulating
oxidative
stress,
inflammation
metabolic
processes,
all
of
which
central
pathogenesis
CHD
individuals
Through
influencing
these
pathways,
helps
reduce
endothelial
dysfunction,
prevent
formation
atherosclerotic
plaques
stabilize
existing
plaques,
thereby
decreasing
overall
The
present
review
underscores
important
role
serving
as
therapeutic
intervention
molecule
tackling
complications
stemming
from
Furthermore,
it
highlights
need
further
studies
clarify
how
influences
depression
at
molecular
level.
ultimate
goal
this
research
will
be
translate
findings
into
practical
clinical
strategies.
Translational Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 17, 2025
The
microbiota-gut-brain
axis
plays
a
pivotal
role
in
neuropsychiatric
disorders,
particularly
depression.
Escitalopram
(ESC)
is
first-line
antidepressant,
however,
its
regulatory
mechanisms
on
the
treatment
of
depression
remain
unclear.
antidepressant
effects
ESC
were
evaluated
using
forced
swim
test
Wistar-Kyoto
(WKY)
rats,
while
damage
gut
and
brain
regions
was
assessed
through
H&E
staining
immunohistochemistry.
therapeutic
WKY
rats
with
depression-like
behavior
investigated
16S
rRNA
sequencing
microbiota,
serum
untargeted
metabolomics,
hippocampal
proteomics.
Results
indicated
that
intervention
improved
depressive-like
behaviors,
as
evidenced
by
increased
swimming
times
also
restored
intestinal
permeability
tissue
integrity.
Significant
changes
microbiota
composition,
an
increase
Bacteroides
barnesiae,
well
increases
sphingolipid
metabolites
(Sphinganine
1-phosphate,
Sphingosine,
Sphingosine-1-phosphate)
proteins
(Sptlc1,
Enpp5,
Enpp2),
strongly
correlated.
These
robust
correlations
suggest
may
exert
modulating
metabolism
influence
microbiota.
Accordingly,
this
research
elucidates
novel
underlying
efficacy
highlights
importance
mediating
these
effects.
