Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 217 - 222
Published: Jan. 1, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117084 - 117084
Published: Aug. 1, 2024
The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress (OS), which induce gene mutations, protein denaturation, and lipid peroxidation directly or indirectly. expression is reduced ATP level in cells, increased cytoplasmic Ca
Language: Английский
Citations
41
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102275 - 102275
Published: March 15, 2024
Language: Английский
Citations
9
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 550 - 550
Published: March 21, 2024
This review discusses the relationship between cellular senescence and radiation exposure. Given wide range of ionizing sources encountered by people in professional medical spheres, as well influence natural background radiation, question effect on biological processes, particularly aging remains highly relevant. The parallel radiation-induced reveals common aspects underlying these processes. Based recent scientific data, key points effects processes associated with aging, such genome instability, mitochondrial dysfunction, altered expression miRNAs, epigenetic profile, manifestation senescence-associated secretory phenotype (SASP), are discussed. Unraveling molecular mechanisms can make a valuable contribution to understanding genetic basis age-associated diseases context environmental
Language: Английский
Citations
9
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 259 - 259
Published: Feb. 24, 2025
One of the major causes senescence is oxidative stress caused by ROS, which mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches reduce them have not yet been developed. In this study, we screened secondary metabolites that plants produce under and discovered sauchinone as a potential candidate. Sauchinone induced function recovery, enabling efficient electron transport within chain (ETC). This led decrease in production, byproduct inefficient transport. The reduction rejuvenated senescence-associated phenotypes. To understand underlying mechanism rejuvenates carried out RNA sequencing found VAMP8 key gene. was downregulated sauchinone. Knockdown decreased levels subsequently function, similar effect Taken together, these studies revealed novel reduces regulating expression. Our results open new avenue aging research control production.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10494 - 10494
Published: June 22, 2023
Liposomes modified with tetradecyltriphenylphosphonium bromide dual loading of α-tocopherol and donepezil hydrochloride were successfully designed for intranasal administration. Physicochemical characteristics cationic liposomes such as the hydrodynamic diameter, zeta potential, polydispersity index within range from 105 to 115 nm, +10 +23 mV, 0.1 0.2, respectively. In vitro release curves analyzed using Korsmeyer-Peppas, Higuchi, First-Order, Zero-Order kinetic models. Nanocontainers surfactant statistically better penetrate into mitochondria rat motoneurons. Imaging brain slices revealed penetration nanocarriers brain. Experiments on transgenic mice an Alzheimer's disease model (APP/PS1) demonstrated that administration 21 days resulted in enhanced learning abilities a reduction formation rate Aβ plaques entorhinal cortex hippocampus
Language: Английский
Citations
21
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176632 - 176632
Published: May 6, 2024
Myocardial fibrosis (MF) is a pivotal pathological process implicated in various cardiovascular diseases, particularly heart failure. Astragaloside IV (AS-IV), natural compound derived from Astragalus membranaceus, possesses potent cardioprotective properties. However, the precise molecular mechanisms underlying its anti-MF effects, relation to senescence, remain elusive. Thus, this study aimed investigate therapeutic potential and of AS-IV treating ISO-induced MF mice, employing transcriptomics, proteomics, vitro, vivo experiments. We assessed positive effects on using HE staining, Masson ELISA, immunohistochemical transthoracic echocardiography, transmission electron microscopy, DHE fluorescence staining. Additionally, we elucidated regulatory role through comprehensive transcriptomics proteomics analyses, complemented by Western blotting RT-qPCR validation pertinent pathways. Our findings demonstrated that treatment markedly attenuated myocardial injury oxidative stress, concomitantly inhibiting release SASPs. Furthermore, integrated analyses revealed mechanism was associated with regulating cellular senescence p53 signaling pathway. These results highlight exerts not only stress but also modulating
Language: Английский
Citations
7
Biogerontology, Journal Year: 2024, Volume and Issue: 25(6), P. 923 - 941
Published: Aug. 28, 2024
Language: Английский
Citations
7
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 687, P. 133539 - 133539
Published: Feb. 24, 2024
Language: Английский
Citations
4
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 224, P. 9 - 22
Published: Aug. 14, 2024
Language: Английский
Citations
4
Aging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Aging | doi:10.18632/aging.206207. Yun Haeng Lee, Eun Young Jeong, Ye Hyang Kim, Ji Ho Park, Jee Hee Yoon, Yoo Jin So Hun Yeon Kyung Nam, Yoon Cha, Seong Youngjoo Byun, Song Seok Shin, Joon Tae Park
Citations
0