Published: Nov. 15, 2024
Language: Английский
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(2)
Published: March 1, 2024
Liposomes-microscopic phospholipid bubbles with bilayered membrane structure-have been a focal point in drug delivery research for the past 30 years. Current liposomes possess blend of biocompatibility, loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying size, charge, lipid composition, ratio, have developed to address diseases specific organs, thereby enhancing circulation, accumulation at lesion sites, intracellular delivery, treatment efficacy various organ-specific diseases. For further successful development this field, review summarized liposomal strategies targeting different organs series major human diseases, including widely studied cardiovascular liver spleen immune chronic or acute kidney injury, neurodegenerative tumors. It highlights recent advances liposome-mediated therapeutic agent disease intervention organ rehabilitation, offering practical guidelines designing organ-targeted liposomes. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials Lipid-Based Structures.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12312 - 12312
Published: Aug. 1, 2023
A synthesis procedure and aggregation properties of a new homologous series dicationic gemini surfactants with dodecane spacer two carbamate fragments (N,N'-dialkyl-N,N'-bis(2-(ethylcarbamoyloxy)ethyl)-N,N'-dimethyldodecan-1,6-diammonium dibromide, n-12-n(Et), where n = 10, 12, 14) were comprehensively described. The critical micelle concentrations obtained using tensiometry, conductometry, spectrophotometry, fluorimetry. thermodynamic parameters adsorption micellization, i.e., maximum surface excess (Гmax), the area per surfactant molecule (Amin), degree counterion binding (β), Gibbs free energy micellization (∆Gmic), calculated. Functional activity surfactants, including solubilizing capacity toward Orange OT indomethacin, incorporation into lipid bilayer, minimum inhibitory concentration, bactericidal fungicidal concentrations, was determined. Synthesized further used for modification liposomes dual-loaded α-tocopherol donepezil hydrochloride intranasal treatment Alzheimer's disease. have high stability (more than 5 months), significant positive charge (approximately + 40 mV), encapsulation efficiency rhodamine B, α-tocopherol, hydrochloride. Korsmeyer-Peppas, Higuchi, first-order kinetic models to process in vitro release curves Intranasal administration loaded 21 days prevented memory impairment decreased number Aβ plaques by 37.6%, 40.5%, 72.6% entorhinal cortex, DG, CA1 areas hippocampus brain transgenic mice disease model (APP/PS1) compared untreated animals.
Language: Английский
Citations
12
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(3), P. 130562 - 130562
Published: Jan. 11, 2024
Language: Английский
Citations
4
Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102442 - 102442
Published: Sept. 23, 2024
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 128 - 128
Published: Jan. 17, 2025
Alzheimer's disease (AD) represents an escalating global health crisis, constituting the leading cause of dementia among elderly and profoundly impairing their quality life. Current FDA-approved drugs, such as rivastigmine, donepezil, galantamine, memantine, offer only modest symptomatic relief are frequently associated with significant adverse effects. Faced this challenge in line advances understanding pathophysiology neurodegenerative condition, various innovative therapeutic strategies have been explored. Here, we review novel approaches inspired by advanced knowledge underlying pathophysiological mechanisms disease. Among alternatives, immunotherapy stands out, employing monoclonal antibodies to specifically target eliminate toxic proteins implicated AD. Additionally, use medicinal plants is examined, synergistic effects components may confer neuroprotective properties. The modulation gut microbiota also addressed a peripheral strategy that could influence neuroinflammatory degenerative processes brain. Furthermore, potential emerging approaches, microRNAs regulate key cellular nanotherapy, which enables precise drug delivery central nervous system, analyzed. Despite promising these strategies, incidence continues rise. Therefore, it proposed achieving effective treatment future require integration combined maximizing different interventions.
Language: Английский
Citations
0
Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 693, P. 134073 - 134073
Published: April 23, 2024
Language: Английский
Citations
3
Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(6), P. 1031 - 1044
Published: June 1, 2024
Language: Английский
Citations
3
Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7229 - 7229
Published: Oct. 23, 2023
This research is based on the concept that mitochondria are a promising target for anticancer therapy, including thatassociated with use of oxidative phosphorylation blockers (mitochondrial poisons). Liposomes L-α-phosphatidylcholine (PC) and cholesterol (Chol) modified cationic surfactants triphenylphosphonium (TPPB-n, where n = 10, 12, 14, 16) imidazolium (IA-n(OH), head groups were obtained. The physicochemical characteristics liposomes at different surfactant/lipid molar ratios determined by dynamic/electrophoretic light scattering, transmission electron microscopy, spectrophotometry. hydrodynamic diameter all systems was within 120 nm polydispersity index no more than 0.24 even after 2 months storage. It shown cationization leads to an increase in internalization nanocontainers pancreatic carcinoma (PANC-1) duodenal adenocarcinoma (HuTu 80) cells compared unmodified liposomes. Also, using confocal it TPPB-14 IA-14(OH) statistically better colocalize tumor ones. At next stage, mitochondrial poison rotenone (ROT) loaded into optimal loading concentration ROT 0.1 mg/mL. Korsmeyer-Peppas Higuchi kinetic models used describe release mechanism from vitro. A significant reduction IC
Language: Английский
Citations
7
Medical Principles and Practice, Journal Year: 2024, Volume and Issue: 33(4), P. 301 - 309
Published: Jan. 1, 2024
Alzheimer’s disease (AD) is the most common cause of neurodegenerative impairment in elderly people. Clinical characteristics include short-term memory loss, confusion, hallucination, agitation, and behavioral disturbance. Owing to evolving research biomarkers, AD can be discovered at early onset, but currently considered a continuum, which suggests that pharmacotherapy efficacious preclinical phase, possibly 15–20 years before discernible onset. Present developments therapy aim respond this understanding go beyond drug families relieve clinical symptoms. Another important factor development emergence precision medicine aims tailor treatment specific patients or patient subgroups. This relatively new platform would categorize on basis parameters like aspects, brain imaging, genetic profiling, genetics, epidemiological factors. review enlarges recent progress design use antisense molecules, antibodies, antioxidants, small gene editing stop reverse relevant biomarkers.
Language: Английский
Citations
2