MONITORING OF MICROPLASTICS IN WATER AND COMMERCIAL FISH IN TRANSBOUNDARY FISHERIES AREAS

Published: Dec. 11, 2024

Shukurov Murodbek Ollamurodogly Resuscitator Children's hospital of the city Yangiyul Safarboyev Izzat Bohodorovich YangiyulRelevance.The most common causes prerenal acute renal failure (ARF) in children are dehydration against background gastroenteritis, accompanied by fluid loss through gastrointestinal tract (vomiting, diarrhea), exogenous (poisoning) and endogenous (sepsis) intoxications, so-called "losses third space" (with burns, nephrotic syndrome, liver diseases).Serious consequences oliguria / anuria.Early initiation extracorporeal detoxification helps to prevent development multiple organ failure.Numerous studies have supported concept that antihypertensive therapy slows down rate progression CKD.The negative effect anuric phase on erythropoiesis is known [1][2][3][4].However, there not enough data evaluate effectiveness anemia correction under 3 years age, which served as basis for this study.Keywords: anemia,

Language: Английский

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Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(1), P. 176 - 196

Published: March 5, 2024

Major depressive disorder (MDD), a prevalent mental illness, is marked by complex mixture of biological factors. This review focuses on the roles oxidative stress, tryptophan-serotonin metabolism, brain-derived neurotrophic factor (BDNF), and hypothalamic–pituitary–adrenal (HPA) axis in MDD’s pathophysiology. Oxidative defined as an imbalance between pro-oxidants antioxidants, closely linked to neurobiological changes. The tryptophan (TRP)-/serotonin (5-HT) metabolic pathway also known be crucial mood regulation, with its dysregulation being central aspect MDD. Additionally, BDNF, key for neuronal growth plasticity, often shows alterations MDD patients, supporting role disorder’s progression. Furthermore, HPA axis, which manages stress response, frequently disrupted MDD, further contributing pathology. In addition exploring these mechanisms, this explores pharmacotherapy including new advances. These advancements treatment strategies are managing effectively. Understanding mechanisms latest pharmacological interventions essential developing more effective treatments

Language: Английский

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Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

This study investigates the therapeutic effectiveness of intranasal dantrolene nanoparticles pretreatment to inhibit lipopolysaccharide (LPS)-induced pathological inflammation and synapse destruction depressive anxiety behavior in mice. B6SJLF1/J adult mice were pretreated with (dantrolene: 5mg/kg), daily, Monday Friday, 5 days per week, for 4 weeks. Then, treated an intraperitoneal injection LPS (5mg/kg) one time. Behavioral tests depression performed 24 hours after a one-time injection. Biomarkers pyroptosis-related cytokines (IL-1β IL-18) blood brain measured using enzyme-linked immunosorbent assay (ELISA) immunoblotting, respectively. The changes primary proteins activation inflammatory pyroptosis (NLRP3: NLR family pyrin domain containing 3, Caspase-1, N-GSDMD: N terminal protein gasdermin D) (PSD-95 synpatin-1) brains immunoblotting. Intranasal robustly inhibited LPS-induced behavior. significantly elevation IL-1β IL-18 pyroptosis. ameliorated decrease PSD-95 synpatin-1 brains. Thus, have demonstrated neuroprotection against inflammation-mediated behaviors should be studied further as future effective drug treatment major disorder or psychiatric disorder.

Language: Английский

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Natural compounds for oxidative stress and neuroprotection in schizophrenia: composition, mechanisms, and therapeutic potential

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: 27(11), P. 1306 - 1320

Published: March 11, 2024

Objective An imbalance between the generation of reactive oxygen species (ROS) and body's antioxidant defense mechanisms is believed to be a critical factor in development schizophrenia (SCZ) like neurological illnesses. Understanding roles ROS SCZ potential activity natural antioxidants against could lead more effective therapeutic options for prevention treatment illness.

Language: Английский

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Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: June 13, 2024

Major depressive disorder (MDD) is a recurrent episodic mood that represents the third leading cause of disability worldwide. In MDD, several factors can simultaneously contribute to its development, which complicates diagnosis. According practical guidelines, antidepressants are first-line treatment for moderate severe major episodes. Traditional strategies often follow one-size-fits-all approach, resulting in suboptimal outcomes many patients who fail experience response or recovery and develop so-called “therapy-resistant depression”. The high biological clinical inter-variability within lack robust biomarkers hinder finding specific therapeutic targets, contributing failure rates. this frame, precision medicine, paradigm tailors medical interventions individual characteristics, would help allocate most adequate effective each patient while minimizing side effects. particular, multi-omic studies may unveil intricate interplays between genetic predispositions exposure environmental through study epigenomics, transcriptomics, proteomics, metabolomics, gut microbiomics, immunomics. integration flow information into molecular pathways produce better than current psychopharmacological targets singular mainly related monoamine systems, disregarding complex network our organism. concept system biomedicine involves analysis enormous datasets generated with different technologies, creating “patient fingerprint”, defines underlying mechanisms every patient. This review, centered on explores approaches as tools prediction MDD at single-patient level. It investigates how combining existing technologies used diagnostic, stratification, prognostic, treatment-response discovery artificial intelligence improve assessment MDD.

Language: Английский

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Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders

Clinics and Practice, Journal Year: 2023, Volume and Issue: 13(4), P. 768 - 779

Published: July 5, 2023

Oxidative stress is defined as the imbalance between production of free radicals and their removal by antioxidants, leading to accumulation subsequent organ tissue damage. Antioxidant status its role in has been observed a number psychological disorders. Glutathione commonly referred principal antioxidant brain and, therefore, plays critical maintaining redox homeostasis. Reduced levels glutathione increase vulnerability oxidative stress, may be associated with development progression several psychiatric Within this review, we focus on analyzing potential associations pathway disorders: major depressive disorder, schizophrenia, bipolar generalized anxiety disorder. Our research suggests that studies regarding these four disorders have shown decreased GSH association diseased states; however, conflicting results note no significant variance enzymes and/or metabolites based state. In studying NAC administration an adjunct therapy, various augment therapy aid symptomatic management for disorders, while contrasting exist within literature. Based findings throughout there room study further suggest need such pathways consideration interactions first-line pharmacotherapy, use antioxidants supplemental therapy.

Language: Английский

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Biomarkers of Postpartum Depression: A Narrative Review

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(20), P. 6519 - 6519

Published: Oct. 14, 2023

Postpartum depression (PPD) is a disorder that impairs the formation of relationship between mother and child, reduces quality life for affected women to functionally significant degree. Studying markers associated with PPD can help in early detection, prevention, or monitoring treatment. The purpose this paper review biomarkers linked present selected theories on pathogenesis disease based data from biomarker studies. complex etiology specificity sensitivity markers, but they remain valuable source information clinicians. biggest challenge future will be translate high-tech methods detecting postpartum into more readily available less costly ones. Population-based studies are needed test utility potential markers.

Language: Английский

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Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 16, 2025

The consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food and depressive symptoms in Chinese populations has not been clarified. Furthermore, factors that mediate association frequency are unknown. Questionnaires were employed to collect data from 6,417 new students at Chongqing Medical University autumn 2023, including sociodemographic information, frequency, physical activity levels (measured by International Physical Activity Questionnaire Short Form), Patient Health Questionnaire-9). Multiple linear regression mediation analysis performed. imputations used fill missing through sensitivity analyses. Among 6417 participants, 2,606 (40.6%) ordered least once a week, with 235 (3.7%) them ordering every day. Takeaway was significantly associated (β=0.034, P=0.006), partially mediated this (95% bootstrap confidence interval=0.0024, 0.0371). study highlights negative emotional well-being, emphasizing need focus on health frequent consumers. Moreover, our suggests increased may alleviate takeaway-induced mood-related outcomes.

Language: Английский

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Estrogen metabolites and H202 - missing elements in the pathophysiology of treatment-resistant depression?

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103547 - 103547

Published: Feb. 20, 2025

The pathogenesis of depression is complex and heterogeneous, the management this disease remains unsatisfactory, so mechanisms therapeutic strategies are constantly being sought. This study aimed to determine potential role estrogen metabolites in treatment-resistant (TRD) based on determination concentrations estrogens their hydrogen peroxide (H202) biological material patients with TRD. In study, we observed for first time an association between unbalanced metabolism elevated H202 levels TRD patients. Reduced 2-methoxyestradiol (2-ME2), 17α-estradiol (α-E2) 17β-estradiol (β-E2) may be due abnormal toward neurotoxic semiquinones quinones which a as yet undescribed mechanism responsible generating oxidative stress (OS)

Language: Английский

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Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms

Current Research in Toxicology, Journal Year: 2025, Volume and Issue: 8, P. 100225 - 100225

Published: Jan. 1, 2025

Language: Английский

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