Grape Pomace as a Source of Phenolics for the Inhibition of Starch Digestion Enzymes: A Comparative Study and Standardization of the Efficacy DOI Creative Commons
P.S.C. Sri Harsha, Vera Lavelli

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4103 - 4103

Published: Dec. 18, 2024

The increase in the incidence of hyperglycemia and diabetes poses challenge finding cost-effective natural inhibitors starch digestion enzymes. Among compounds, phenolics have been considered as promising candidates. aims this study were follows: (a) to investigate effectiveness inhibition different winemaking byproducts towards intestinal brush border α-glucosidase pancreatic α-amylase vitro; (b) calculate an efficacy index relative standard acarbose for phenolic pool byproducts, well isolated compounds pools plants studied literature, order rank with respect reference drug other alternatives. red grape skins showed highest inhibitory activities both α-amylase, which were, on average, 4.9 2.6 µg equivalents/µg total (µg Ac eq/µg GAE), respectively. A correlation was observed between contents their effectiveness, is useful standardizing extracts obtained from processes. In general, activity higher than those namely anthocyanins monomeric polymeric flavanols flavonols, probably due synergistic effects among compounds. Hence, bioactive fractions could be produced focus functionality rather purity, line principles sustainable processing. Based developed compare phenolic-rich literature enzyme inhibitors, proved

Language: Английский

DPPH radical scavenging assay: A tool for evaluating antioxidant activity in 3 % cobalt – Doped hydroxyapatite for orthopaedic implants DOI
Ranbir Kumar,

Deep Shikha,

Sanjay Kumar Sinha

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(8), P. 13967 - 13973

Published: Jan. 30, 2024

Language: Английский

Citations

15
Valorization of Grape Pomace: A Review of Phenolic Composition, Bioactivity, and Therapeutic Potential DOI Creative Commons

Anna Karastergiou,

Anne‐Laure Gancel, Michaël Jourdes

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1131 - 1131

Published: Sept. 19, 2024

Vitis vinifera L., commonly known as grapes, is one of the most widely cultivated crops worldwide, with over 80% used for wine production. However, winemaking process generates substantial residues, including grape pomace (GP), lees, and wastewater, which can pose significant environmental economic challenges. Among these, GP stands out not only a waste product but also rich source polyphenols—bioactive compounds recognized antioxidant anti-inflammatory properties. Recent advancements have expanded application GP-derived extracts, particularly in health food industries, due to their potent bioactive This review provides comprehensive overview valorization GP, focusing on its phenolic composition therapeutic potential. It evokes innovative, environmentally friendly extraction techniques integrated methods chemical analysis these valuable compounds. Additionally, benefits polyphenols are explored, recent experimental findings examining metabolism highlighting key role gut microbiota processes. These insights contribute deeper understanding biological activity extracts underscore growing significance high-added-value product. By illustrating how by-products be transformed into natural agents, this emphasizes importance sustainable development eco-friendly management practices, significantly contributing advancement circular economy.

Language: Английский

Citations

15
Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis DOI Creative Commons
Weidong Hu,

Lin Du,

Jianjian Shao

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(5), P. 103621 - 103621

Published: March 6, 2024

In the large poultry industry, where farmed chickens are fed at high density, prevalence of pathogens and repeated vaccinations induce immune stress, which can significantly decrease production performance increase mortality. This study was designed to shed light on molecular mechanisms metabolic pathways involved in stress through an in-depth analysis transcriptomic metabolomic changes jejunum samples from broilers. Two groups were established for experiment: a control group LPS group. received intraperitoneal injection solution dose 250 μg per kg 12, 14, 33, 35 days age, whereas sterile saline injection. The severity assessed using Disease Activity Index. A jejunal section collected measure intestinal villus structure (villus length crypt depth). RNA sequencing metabolomics data conducted reveal differentially expressed genes metabolites. results showed that DAI index increased height/crypt depth decreased total 96 672 accumulating metabolites detected by compared comprehensive 23 enriched appetite, nutrient absorption, energy substance metabolism disorders ferroptosis play important role Our findings provide deeper understanding responses broilers LPS-induced suggesting potential targets therapeutic strategies improve broiler chickens.

Language: Английский

Citations

6
Exploring the Benefits of Nutritional and Chemical Characteristics of Touriga Nacional and Arinto Varieties (Vitis vinifera L.) DOI Creative Commons
Paula Pereira, Lídia Palma, Carla Palma

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1535 - 1535

Published: May 15, 2024

Environmental degradation leads to an unsustainable food system. In addition this issue, the consumption of foods that improve people’s health and well-being is recommended. One alternatives undoubtedly use by-products winemaking, namely in form grape pomace flour (GPF). To verify benefits using Touriga Nacional Arinto (Vitis vinifera L.) varieties, analytical determinations were made identify quantify different components. terms nutritional characterization, GPF showed results indicate better quality than GPF. The samples had protein contents 10.13% 8.38%, polyunsaturated fatty acids 6.66% 5.18%, soluble dietary fiber 14.3% 1.7%, insoluble 55.1% 46.4%, respectively. anthocyanins, proanthocyanidins, flavonols presented detected by HPLC-DAD/ESI-MS. Atomic absorption spectrometry revealed elevated concentrations certain elements compared Arinto, with former showing higher levels aluminum (130 mg/kg) iron (146 against latter’s Al (120 Fe (112 content. could become a valuable ingredient due its high content various polyphenols.

Language: Английский

Citations

5
Exploitation of Natural By-Products for the Promotion of Healthy Outcomes in Humans: Special Focus on Antioxidant and Anti-Inflammatory Mechanisms and Modulation of the Gut Microbiota DOI Creative Commons
Luigì Santacroce, Lucrezia Bottalico, Ioannis Alexandros Charitos

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 796 - 796

Published: June 29, 2024

Daily, a lot of food is wasted, and vegetables, fruit, cereals as well marine products represent the major sources unwanted by-products. The sustainability, waste recovery, revalorization by-products have been proposed main goals so-called circular economy. In fact, wastes are enriched in endowed with beneficial effects on human health. Grape, olives, rice contain different compounds, such polyphenols, dietary fibers, polysaccharides, vitamins, proteins, which exert antioxidant anti-inflammatory activities, inhibiting pro-oxidant genes Nuclear Factor kappa-light-chain-enhancer activated B cells (NF-kβ) pathway, demonstrated by vitro vivo experiments. Dietary fibers act upon gut microbiota, expanding bacteria, contribute to healthy outcomes. Furthermore, foods, even including microalgae, arthropods, fish, rich carotenoids, polyunsaturated fatty acids, chitooligosaccharides, afford protection. present review will cover derived from wastes, describing mechanisms action involved modulation microbiota. some also explored clinical trials, while others, by-products, need more investigation for their full exploitation bioactive compounds humans.

Language: Английский

Citations

5
Changes in the cocoa shell dietary fiber and phenolic compounds after extrusion determine its functional and physiological properties DOI Creative Commons
Vanesa Benítez, Miguel Rebollo‐Hernanz, Cheyenne Braojos

et al.

Current Research in Food Science, Journal Year: 2023, Volume and Issue: 6, P. 100516 - 100516

Published: Jan. 1, 2023

The influence of different extrusion conditions on the cocoa shell (CS) dietary fiber, phenolic compounds, and antioxidant functional properties was evaluated. Extrusion produced losses in CS fiber (3–26%), especially insoluble fraction, being more accentuated at higher temperatures (160 °C) lower moisture feed (15–20%). soluble fraction significantly increased 135 °C because solubilization galactose- glucose-containing polysaccharides. extruded treated 160 °C–25% showed highest increase total (27%) free (58%) accompanied by an indirect (10%) direct (77%) capacity. However, promising results relative to compounds' bioaccessibility after vitro simulated digestion were observed for 135°C–15% conditions. CS' physicochemical techno-functional affected extrusion, producing extrudates with bulk density, a diminished capacity hold oil (22–28%) water (18–65%), improved swelling (14–35%). exhibited glucose adsorption (up 2.1-fold, °C–15% moisture) α-amylase inhibitory (29–54%), their diffusion delaying ability (73–91%) starch retardation 2.8-fold, moisture). Moreover, preserved its cholesterol bile salts binding pancreatic lipase properties. These findings generated knowledge valorization through produce foods rich health-promoting due extrusion-triggered solubilization.

Language: Английский

Citations

13
Cocoa shell ingredients improve their lipid-lowering properties under simulated digestion: In vitro and HepG2 cells study DOI Creative Commons
Cheyenne Braojos, Miguel Rebollo‐Hernanz, Silvia Cañas

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 196, P. 115037 - 115037

Published: Sept. 4, 2024

Language: Английский

Citations

4
Modulating Effects of Grape Pomace on the Intestinal Antioxidative and Inflammatory Status in Fattening Pigs DOI Creative Commons
Loredana Horodincu,

Andrei Claudiu Proca,

Bogdan Gabriel Șlencu

et al.

Agriculture, Journal Year: 2025, Volume and Issue: 15(7), P. 740 - 740

Published: March 30, 2025

Polyphenol-rich plant products are widely used as feed additives for their anti-inflammatory, antioxidant, and antimicrobial properties. The aim of this research is to test the hypothesis that feeding grape pomace (GP) fattening pigs modulates intestinal immune antioxidant response, promotes morphostructure small intestine, improves growth performance. Fifty Piétrain were randomly divided into five groups, each consisting 10 pigs. groups fed a basal diet with no supplementation (control) or supplemented 1 gGP/kg (E1), 5 (E2), (E3), 15 (E4). doses selected based on preliminary tests. slaughtered after 90 days, duodenum, jejunum, ileum, caecum sampled. We recommend dose because it leads many beneficial effects, including significantly increased villous height, crypt depth, V/C ratio in duodenum jejunum (p < 0.05). It also decreased expression pro-inflammatory markers such IL-1β ileum caecum, TNF-α multiple segments, MHC-II caecum. Additionally, activity was promoted through immunohistochemical Nrf2 reduced NF-kB p65 expression. Growth performance improved, higher ADG = 0.01) ADFI values than those control group. In conclusion, polyphenol-rich can be supplement pig diets maintain health productive

Language: Английский

Citations

0
Best Practices and Considerations for Conducting Research on Diet-Gut Microbiome Interactions and their Impact on Health in Adult Populations: An Umbrella Review DOI Creative Commons

Tatiana Diacova,

Christopher J. Cifelli, Cindy D. Davis

et al.

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100419 - 100419

Published: April 1, 2025

Language: Английский

Citations

0
Red Wine Grape Pomace Restores Gut Barrier Function and Improves Survival in Diet-Induced Ischemic Heart Disease DOI Creative Commons
Katherine Rivera, Leticia González,

L. Parra

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 574 - 574

Published: May 10, 2025

Red wine grape pomace (RWGP), a winemaking by-product rich in phenolics, flavonoids, and dietary fiber, has shown promise mitigating cardiovascular disease (CVD), however, its mechanisms of action remain incompletely understood. This study comprehensively profiled the phenolic composition RWGP—including free, esterified, etherified, insoluble-bound fractions—and evaluated effects RWGP supplementation on gut barrier integrity, inflammation, oxidative stress, survival SR-B1−/−ApoE-R61h/h mice, model diet-induced lethal ischemic heart disease. significantly improved rates restored function, as evidenced by lower plasma FITC-dextran LPS levels, increased circulating ZO-1 reduced histopathological colon damage. In addition, pro-inflammatory cytokines (IL-1β) showed trend toward attenuating systemic stress (TBARS). Analysis compounds indicated significant presence phenolics. Nevertheless, beneficial observed are likely attributable to synergistic actions RWGP’s complex phytochemical fiber composition. These results highlight potential sustainable, gut-targeted functional food ingredient for CVD prevention management.

Language: Английский

Citations

0