Communications Chemistry,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: March 11, 2025
Effective
chemical
catalysts
can
artificially
control
intracellular
metabolism.
However,
in
conventional
catalytic
chemistry,
activity
and
cytotoxicity
have
a
trade-off
relationship;
thus,
driving
living
cells
remains
challenging.
To
overcome
this
critical
issue
at
the
interface
between
chemistry
biology,
we
developed
cell-driven
allosteric
that
exert
specific
times.
The
synthesized
redox
up-
downregulated
their
foldase-
antioxidase-like
activities
response
to
varying
Ca2+
concentrations,
which
is
key
factor
for
maintenance
of
status
cells.
In
absence
or
low
compounds
were
mostly
inactive
hence
did
not
affect
cell
viability.
contrast,
under
conditions
with
elevated
cytosolic
activated
resisted
imbalance
induced
by
reactive
oxygen
species
generated
Ca2+-stimulated
mitochondria.
Smart
crosstalk
biological
phenomena
may
provide
platform
new
prodrug
development
guidelines.
metabolism,
however,
Here,
authors
develop
Ca2+-responsive
artificial
resist
Protein & Cell,
Journal Year:
2023,
Volume and Issue:
15(3), P. 157 - 190
Published: July 19, 2023
Ubiquitination/ubiquitylation,
one
of
the
most
fundamental
post-translational
modifications,
regulates
almost
every
critical
cellular
process
in
eukaryotes.
Emerging
evidence
has
shown
that
essential
components
numerous
biological
processes
undergo
ubiquitination
mammalian
cells
upon
exposure
to
diverse
stresses,
from
exogenous
factors
reactions,
causing
a
dazzling
variety
functional
consequences.
Various
forms
ubiquitin
signals
generated
by
ubiquitylation
events
specific
milieus,
known
as
codes,
constitute
an
intrinsic
part
myriad
stress
responses.
These
events,
leading
proteolytic
turnover
substrates
or
just
switch
functionality,
initiate,
regulate,
supervise
multiple
stress-associated
responses,
supporting
adaptation,
homeostasis
recovery,
and
survival
stressed
cells.
In
this
review,
we
attempted
summarize
crucial
roles
response
different
environmental
intracellular
while
discussing
how
stresses
modulate
system.
This
review
also
updates
recent
advances
understanding
machinery
well
responses
discusses
some
important
questions
may
warrant
future
investigation.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Jan. 23, 2024
MEK
inhibitors
(MEKi)
were
shown
to
be
clinically
insufficiently
effective
in
patients
suffering
from
BRAF
wild-type
(BRAF
WT)
melanoma,
even
if
the
MAPK
pathway
was
constitutively
activated
due
mutations
NRAS
or
NF-1.
Thus,
novel
combinations
are
needed
increase
efficacy
and
duration
of
response
MEKi
WT
melanoma.
Disulfiram
its
metabolite
diethyldithiocarbamate
known
have
antitumor
effects
related
cellular
stress,
induction
endoplasmic
reticulum
(ER)
stress
found
synergize
with
NRAS-mutated
melanoma
cells.
Therefore,
we
investigated
combination
both
therapeutics
test
their
on
BRAF-WT
cells
compared
them
monotherapy
using
trametinib.
The
combined
therapy
disulfiram
trametinib
evaluated
a
series
cell
lines
by
measuring
viability
apoptosis
induction.
Cytotoxicity
additionally
assessed
3D
spheroids,
ex
vivo
slice
cultures,
xenograft
mouse
models.
treatment
studied
at
RNA
protein
levels
decipher
mode
action.
Intracellular
intratumoral
copper
measurements
performed
investigate
role
ions
cytotoxicity
MEKi.
Diethyldithiocarbamate
enhanced
trametinib-induced
2D
culture
Mechanistically,
copper-dependent
oxidative
ER
led
Janus
kinase
(JNK)-mediated
This
mechanism
also
detectable
patient-derived
models
resulted
significantly
improved
therapeutic
effect
represent
an
attractive
pharmaceutical
approach
induce
that
potentiates
inhibition
may
interesting
candidate
for
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
T-2
toxin
is
a
highly
toxic
fungal
that
threatens
humans
and
animals'
health.
As
major
detoxifying
metabolic
organ,
the
kidney
also
target
of
toxin.
This
article
reviews
nephrotoxicity
research
progress,
covering
renal
structure
function
damage,
mechanisms,
detoxification
methods
to
future
directions.
damages
structure,
causing
dysfunction.
The
mechanism
involves
multiple
factors
including
oxidative
stress,
endoplasmic
reticulum
mitophagy,
inflammatory
responses,
apoptosis,
which
are
intertwined
interdependent.
Current
strategies
mainly
involve
reducing
in
feedstuff
using
antioxidant
substances,
but
both
have
limits.
Future
should
focus
on
cells
sensitivity
toxin,
exploring
key
molecules
toxin's
nephrotoxicity,
injury's
impact
other
organs,
better
methods.
review
aims
guide
underpin
toxin-induced
prevention
treatment.
Journal of drug targeting,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 30, 2025
Endoplasmic
Reticulum
(ER)
stress
is
intricately
involved
in
cancer
development,
progression
and
response
to
chemotherapy.
ER
related
genes
might
play
an
important
role
predicting
the
prognosis
lung
adenocarcinoma
patients
may
be
manipulated
improve
treatment
outcome
overall
survival
rate.
In
this
review,
we
analyzed
contribution
of
three
major
pathways-IRE1,
ATF6,
PERK-in
pathogenesis
via
modulation
tumor
microenvironment
(TME)
processes
as
metastasis,
angiogenesis,
apoptosis
N-glycosylation.
Furthermore,
discuss
regulatory
microRNAs
fine-tuning
pathways
Non-Small
Cell
Lung
Cancer
(NSCLC).
Our
review
also
highlights
various
promising
strategies
overcome
chemoresistance
by
targeting
pathways,
offering
new
therapeutic
opportunities.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 568 - 568
Published: May 4, 2024
Age-related
macular
degeneration
(AMD)
severely
affects
central
vision
due
to
progressive
and
its
staggering
prevalence
is
rising
globally,
especially
in
the
elderly
population
above
55
years.
Increased
oxidative
stress
with
aging
considered
an
important
contributor
AMD
pathogenesis
despite
multifaceted
risk
factors
including
genetic
predisposition
environmental
agents.
Wet
can
be
managed
routine
intra-vitreal
injection
of
angiogenesis
inhibitors,
but
no
satisfactory
medicine
has
been
approved
for
successful
management
dry
form.
The
toxic
carbonyls
photo-oxidative
degradation
accumulated
bisretinoids
within
lysosomes
initiate
a
series
events
protein
adduct
formation,
impaired
autophagy
flux,
complement
activation,
chronic
inflammation,
which
implicated
AMD.
Therapy
based
on
antioxidants
extensively
studied
promising
effect
reducing
impact
stress.
This
paper
reviews
pathogenesis,
delineates
effectiveness
dietary
nutrition
supplements
clinical
studies,
explores
pre-clinical
studies
antioxidant
molecules,
extracts,
formulations
their
mechanistic
insights.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 353 - 353
Published: March 8, 2024
Many
pathologic
states
can
lead
to
the
accumulation
of
unfolded/misfolded
proteins
in
cells.
This
causes
endoplasmic
reticulum
(ER)
stress
and
triggers
unfolded
protein
response
(UPR),
which
encompasses
three
main
adaptive
branches.
One
these
UPR
branches
is
mediated
by
kinase
RNA-like
ER
(PERK),
an
sensor.
The
primary
consequence
PERK
activation
suppression
global
synthesis,
reduces
workload
facilitates
recovery
function.
Ischemic
stroke
induces
activates
UPR.
Studies
have
demonstrated
involvement
pathway
pathophysiology;
however,
its
role
outcomes
requires
further
clarification.
Importantly,
considering
mounting
evidence
that
supports
therapeutic
potential
aging-related
cognitive
decline
neurodegenerative
diseases,
this
may
represent
a
promising
target
stroke.
Therefore,
review,
our
aim
discuss
current
understanding
ischemic
stroke,
summarize
pharmacologic
tools
for
translational
research
targets
associated
pathways.
