OncoTargets and Therapy, Journal Year: 2024, Volume and Issue: Volume 17, P. 863 - 870
Published: Oct. 1, 2024
Hydrogen (H
Language: Английский
Theranostics, Journal Year: 2024, Volume and Issue: 14(9), P. 3739 - 3759
Published: Jan. 1, 2024
The repair of osteoporotic bone defects remains challenging due to excessive reactive oxygen species (ROS), persistent inflammation, and an imbalance between osteogenesis osteoclastogenesis.
Language: Английский
Citations
15
Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 90 - 90
Published: Jan. 11, 2024
Chronic kidney disease (CKD), which is globally on the rise, has become an urgent challenge from perspective of public health, given its risk factors such as end-stage renal failure, cardiovascular diseases, and infections. The pathophysiology CKD, including dialysis patients, deeply associated with enhanced oxidative stress in both kidneys entire body. Therefore, introduction a safe widely applicable antioxidant therapy expected measure against CKD. Electrolyzed hydrogen water (EHW) generated through electrolysis been confirmed to possess chemical capabilities. In Japan, devices producing this have popular for household drinking water. CKD model experiments conducted date, EHW shown suppress progression damage related hypertension. Furthermore, clinical studies reported that systemic patients undergoing treatment using suppressed, leading reduction incidence complications. future, considering one comprehensive measures holds significant importance. medical utility believed be substantial, further investigation warranted.
Language: Английский
Citations
8
BioFactors, Journal Year: 2024, Volume and Issue: 50(4), P. 756 - 771
Published: Jan. 9, 2024
Abstract Citrus flavanones are recognized as promising bioactives within the concept of healthy aging. Thus, present study investigated effects a nutritionally relevant dose lemon extract (LE) on liver redox regulation and persulfidation levels in 24‐month‐old Wistar rats. LE (40 mg/kg b.m.) was administered orally once daily for 4 weeks. Control groups received either vehicle (sunflower oil) or remained intact. The applied methodology considered qPCR, Western blot, protein evaluation, histochemistry line with immunofluorescence, biochemical assays (glutathione, total ‐SH malonaldehyde; MDA), enzymes serum silico analysis to explore potential interaction/binding between proteins studied paper. Our results showed that increased glutathione peroxidase (GPx), reductase (GR), glutamate–cysteine ligase catalytic modifier subunit, respectively, well Nrf2 gene expressions, but decreased expression superoxide dismutase 2 (SOD2). Upon application, upregulation NRF2, SOD2, GPx, GR, thioredoxin 1 (Trx1). significantly concentration MDA, marker oxidative damage cell. Histological normal histoarchitecture without pathological changes, aligning level hepatic enzymes. Obtained LE, by modulating regulators Trx1, diminishes stress alters levels, suggesting considerable beneficial antioxidant old‐aged liver.
Language: Английский
Citations
4
Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(3)
Published: Feb. 1, 2025
ABSTRACT Ischaemic heart disease (IHD) remains a leading cause of global morbidity and mortality. One significant contributor to the pathology IHD is excessive release inflammatory mediators during progression. Pyroptosis form programmed cell death (PCD) triggered by activation inflammasomes caspase 1. The 1 proteolytically cleaves gasdermin D (GSDMD) activated amino acid terminus (GSDMD‐NT), disruption plasma membrane. This cascade events considered canonical pathway pyroptosis. also caused oxidative stress, thereby triggering noncanonical pyroptosis via caspases 4/5/11. Previous studies have provided compelling evidence close relationship between aetiology (e.g., acute myocardial infarction, ischaemia reperfusion injury chronic infarction), as well association with unfavourable clinical outcomes. Several interventions aimed at targeting demonstrated promising therapeutic benefits against IHD‐related pathologies. review provides mechanistic insights into roles in from vitro, vivo perspectives. In‐depth understanding this area could pave way for future development novel strategies IHD.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Abstract Excessive exposure to ultraviolet (UV) radiation is a major factor in the development of skin photoaging wrinkles. While current treatments can slow progression photoaging, it very difficult achieve complete reversal. This study introduces galvanic cell microneedle (GCMN) patches with magnesium‐containing bipolar electrodes. These operate through mechanism, generating microcurrents and releasing hydrogen gas magnesium ions via redox reaction. The combination hydrogen's antioxidant anti‐inflammatory properties, microcurrent‐induced stimulation migration, magnesium's promotion angiogenesis macrophage M2 polarization synergistically works reverse wrinkles rejuvenate skin. Furthermore, this work examines how GCMNs may influence transforming growth factor‐β/Smad (TGF‐β/Smad) pathway. approach shows promise for advancing research field medical cosmetology.
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41800 - e41800
Published: March 7, 2025
Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses mechanism of molecular hydrogen alleviating oxidative stress. Considering current antioxidant demand clinical dental treatment, we summarize progress and future potential hydrogen's application periodontitis. Finally, taking its treatment periodontitis example, develop Essence-Necessity-Feasibility-Practice (ENFP) benefit evaluation model for whether introduce reagents medical propose our conclusions on before, during, after periodontal surgeries.
Language: Английский
Citations
0
Molecular & Cellular Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Language: Английский
Citations
1
Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 231 - 242
Published: Jan. 1, 2024
Language: Английский
Citations
0
Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 113 - 123
Published: Jan. 1, 2024
Language: Английский
Citations
0
Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)
Published: April 15, 2024
Abstract The gut microbiota (GM) and its potential functions play a crucial role in maintaining host health longevity. aim of this study was to investigate the relationship between GM We collected fecal samples from 92 healthy volunteers (middle-aged elderly: 43–79 years old; longevity: ≥ 90 old) Changshou Town, Zhongxiang City, Hubei, China. In addition, we 30 middle-aged elderly controls (aged 51–70 years) Wuhan, Hubei. 16S rDNA V3 + V4 region sequenced using high-throughput sequencing technology. Diversity analysis results showed that group with longevity low body mass index (BMI) exhibited higher α diversity. However, no significant difference observed β microbiome composition indicate Firmicutes , Proteobacteria Bacteroidota are core phyla all groups. Compared younger individuals, Akkermansia Lactobacillus significantly enriched long-lived group, while Megamonas is reduced. high abundance characteristic populations BMI values. Furthermore, functional prediction had abilities short-chain fatty acid metabolism, amino xenobiotic biodegradation. Taken together, our provides information on population Town. This can serve as valuable addition current research age-related GM. Key points • individuals exhibit alpha diversity Gut did not differ genders Several potentially beneficial bacteria (e.g., Lactobacillus)
Language: Английский
Citations
0