Neonatology surgery and perinatal medicine,
Journal Year:
2023,
Volume and Issue:
8(4(50)), P. 19 - 27
Published: Oct. 26, 2023
The
management
of
premature
infants
with
persistent
pulmonary
hypertension
(PPH)
remains
a
major
problem
in
modernneonatology.
In
recent
years,
scientifi
c
studies
have
identifi
ed
the
role
oxidative
stress
(OS)
development
and
course
PPH.
reserve
for
reducing
mortality
optimizing
respiratory
distress
syndrome
(RDS)
asphyxia
is
an
algorithm
diff
erentiated
approach
to
PPH
infants,
taking
into
account
severity
dynamics
OS,
its
implementation
clinical
practice.
Aim
study.
To
increase
eff
ectiveness
based
on
levels
as
determined
by
urinary
8-hydroxy-2-deoxyguanosine
(8-OHdG).Material
methods.
100
between
26/1-34/6
weeks
gestation
were
included
study:
groupI
consisted
50
RDS,
group
II
–
newborns
RDS
associated
perinatal
asphyxia.
presence
was
all
fi
rst
third
fth
day
life
echocardiography
(EchoCG),
quantitative
determination
8-OHdG
level
(ng/ml)
44
day,
enzyme-
linked
immunosorbent
assay
(ELISA).
For
radiographic
evaluation
PPH,
underwent
chest
radiography
Moore’s,
Schwedel’s
cardiothoracic
index
(CTI).
research
conducted
compliance
bioethical
requirements
part
planned
work
Department
(state
registration
number
0122U000025).Results.
It
found
that
characteristics
signifi
cantly
lower
mean
pressure
artery
(mPAP)
3-5
days
than
children
noted
factors
high
diagnostic
cance
determining
occurrence
are:
birth
weight
<1500
g;
asphyxia;
low
Apgar
score
1st
(1-3
points)
5th
minute
(<7
points);
gestational
age
<30
weeks;
non-appropriateness
age;
male
sex.
Furthermore,
it
biomarker
OS
preterm
correlated
mPAP
life,
had
value
risk
developing
severe
life.
data
comprehensive
radiological
assessment
indices
Moore,
Schwedel,
CTI
analyzed
correlations
established.
Schwedel
showed
highest
reliability
cases.Conclusion.
On
basis
cally
established
relationships
clinical,
laboratory,
genderaspects
pathology
prognostic
values
8-OHdG,
developed.
Determination
degree
allows
us
adjust
individualize
tactics
support
thus
improving
quality
medical
care
prematurely
born
centers,
additional
urine
predict
adverse
complications:
bronchopulmonary
dysplasia,
intraventricular
hemorrhage
III-IV
grade,
retinopathy
II-III
hearing
impairment,
hypoxic-
ischemic
lesions
central
nervous
system
grade
children.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: June 28, 2024
Oxidative
stress
is
a
known
pathogenic
mechanism
in
cardiovascular
disease
(CVD),
yet
the
association
between
dietary
antioxidants
and
CVD
general
population
remains
underexplored.
This
study
leverages
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
to
investigate
of
composite
antioxidant
index
with
US
adults.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 835 - 835
Published: Jan. 20, 2025
Pulmonary
hypertension
associated
with
lung
diseases
and/or
hypoxia
is
classified
as
group
3
in
the
clinical
classification
of
pulmonary
hypertension.
The
efficacy
existing
selective
vasodilators
for
still
unknown,
and
it
currently
a
poor
prognosis.
mechanisms
by
which
occurs
include
hypoxic
vasoconstriction,
vascular
remodeling,
decrease
beds,
endothelial
dysfunction,
endothelial-to-mesenchymal
transition,
mitochondrial
oxidative
stress,
hypoxia-inducible
factors
(HIFs),
inflammation,
microRNA,
genetic
predisposition.
Among
these,
vasoconstriction
subsequent
remodeling
are
characteristic
involving
vasculature
focus
this
review.
Several
have
been
reported
to
mediate
induced
such
HIF-1α
mechanosensors,
including
TRP
channels.
New
therapies
that
target
novel
molecules,
mechanoreceptors,
inhibit
awaited.
Analytical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
The
physiological
and
pathological
processes
in
lungs
indicated
that
ONOO-
acted
as
an
informative
indicator
for
pulmonary
functioning
status
with
the
corresponding
dynamics,
especially
permissive
hypercapnia.
Herein,
peroxynitrite
(ONOO-)
detection
imaging
living
lung
cells,
imidazo-pyridin
derived
fluorescent
probe
IDPD-ONOO
was
developed.
recognized
to
exhibit
a
fluorescence
response
at
490
nm
excitation
wavelength
355
nm.
advantages
of
developed
included
practical
linear
range
(0-100
μM),
high
sensitivity
(Limit
Detection
0.005
rapid
(within
15
min),
pH
tolerance
(7.0-9.0),
selectivity,
low
cyto-toxicity.
Furthermore,
achieved
intracellular
both
exogenous
endogenous
level,
which
meaningful
research
on
mechanism
optimized
optical
implements.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2136 - 2136
Published: Feb. 27, 2025
To
explore
the
molecular
mechanism
of
aerobic
exercise
to
improve
heart
failure
and
provide
a
theoretical
basis
experimental
reference
for
treatment
failure.
Nine-week-old
male
mice
were
used
establish
left
ventricular
pressure
overload-induced
model
by
transverse
aortic
constriction
(TAC).
The
randomly
divided
into
four
groups:
sham
group
(SHAM),
(HF),
+
SKQ1
(HS)
(HE).
in
HE
subjected
moderate-intensity
interventions.
mitochondrion-targeting
antioxidant
(SKQ1)
contains
lipophilic
cation
TPP,
which
targets
scavenging
mitochondrial
ROS.
HS
was
(100
nmol/kg/d)
interventions,
initiated
1
week
after
surgery,
interventions
lasted
8
weeks.
Cardiac
function
assessed
ultrasound,
cardiomyocyte
size
H&E
WGA
staining,
myocardial
fibrosis
Masson's
tissue
oxidative
stress
apoptosis
DHE
TUNEL
fluorescence
respectively.
Western
blotting
detect
expression
quality
control,
inflammation,
apoptosis-related
proteins.
In
cellular
level,
an
vitro
established
isolating
primary
cardiomyocytes
from
neonatal
(2-3
days)
intervening
with
Ang
II
(1
μM)
mimic
Oxidative
membrane
potential
determined
each
JC-1
Myocardial
increased
significantly
cardiac
reduced
mice.
Aerobic
intervention
improved
hypertrophy
significantly.
Meanwhile,
number
DHE-positive
particles
(p
<
0.01)
inhibited
also
DRP1,
Parkin,
BNIP3
protein
0.05,
p
0.01),
OPA1
PINK1
Moreover,
decreased
TUNEL-positive
inflammation-
proteins
NLRP3,
TXNIP,
Caspase-1,
IL-1β,
BAX,
BAK,
p53
0.01).
addition,
AMPK
agonist
AICAR
mitochondria-targeted
ROS
scavenger
ameliorated
AngII-induced
fragmentation
It
shown
that
inhibition
exercise,
turn
inhibits
damage,
improves
reduces
inflammatory
apoptosis,
may
be
important
exerts
endogenous
protective
effects
function.
