The
studies
of
rejuvenation
are
important
for
promoting
health
and
longevity,
preventing
age-related
diseases,
reducing
economic
burdens,
improving
quality
life
addressing
the
challenges
posed
by
an
aging
global
population.
This
review
explores
intersection
aging,
regeneration
bioelectric
fields
examining
emerging
role
membrane
potential
in
processes
like
cell
proliferation,
differentiation,
limb
potentially
aging.
Manipulation
opens
a
novel
dimension
to
landscape
offering
alternative
or
complementary
approach
partial
reprograming
method
presenting
exciting
possibilities
therapeutic
interventions
targeting
cellular
changes.
Theriogenology,
Journal Year:
2025,
Volume and Issue:
236, P. 105 - 113
Published: Feb. 2, 2025
In
vitro
culture
impairs
mitochondrial
metabolism
of
IVP
derived
bovine
embryos
resulting
in
accumulation
reactive
oxygen
species.
Recently,
the
antioxidant
Mito-TEMPO
has
attracted
attention
due
to
its
capability
accumulate
within
mitochondria.
order
investigate
potential
improve
quality
embryos,
this
study
analyzed
developmental
stage
specific
effect
on
capacity,
ROS
balance,
expression
outline
antioxidative
genes
and
cryo-resilience
blastocysts.
three
subsequent
experiments
(1
μM)
was
added
either
maturation
medium
(MTM),
(MTC)
or
both
(MTMC).
Concerning
cleavage-
blastocyst
rates,
no
supplementation
could
be
detected,
although
MTM
and/or
MTC
groups
revealed
significantly
(p
<
0.05)
lower
levels
ROS.
Expression
under
not
affected
group,
whereas
down-regulation
proapoptotic
gene
BAX
observed
as
well
MTMC
groups.
Moreover,
with
functions
mitochondria
(SOD2,
GPX1,
GSTA4)
peroxisomes
(CAT)
group.
contrast,
acting
predominately
outside
(NFE2L2
PRDX1)
affected.
Of
high
impact,
present
for
first
time
greatly
improved
reexpansion
hatching
rates
vitrified-warmed
a
consequence
media.
Collectively,
successfully
proved
that
alleviates
negative
effects
environment
pre-implantation
embryos.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1910 - 1910
Published: Feb. 23, 2025
Reductive
stress
(RS),
characterized
by
excessive
accumulation
of
reducing
equivalents
such
as
NADH
and
NADPH,
is
emerging
a
key
factor
in
metabolic
disorders
cancer.
While
oxidative
(OS)
has
been
widely
studied,
RS
its
complex
interplay
with
endocrine
regulation
remain
less
understood.
This
review
explores
molecular
circuits
bidirectional
crosstalk
between
hormones
RS,
focusing
on
their
role
diabetes,
obesity,
cardiovascular
diseases,
disrupts
insulin
secretion
signaling,
exacerbates
inflammation,
contributes
to
adipose
tissue
dysfunction,
ultimately
promoting
resistance.
In
alters
vascular
smooth
muscle
cell
function
myocardial
metabolism,
influencing
ischemia-reperfusion
injury
outcomes.
cancer,
plays
dual
role:
it
enhances
tumor
survival
buffering
OS
reprogramming,
yet
can
trigger
proteotoxicity
mitochondrial
leading
apoptosis.
Recent
studies
have
identified
RS-targeting
strategies,
including
redox-modulating
therapies,
nanomedicine,
drug
repurposing,
offering
potential
for
novel
treatments.
However,
challenges
remain,
particularly
distinguishing
physiological
from
pathological
conditions
overcoming
therapy-induced
Future
research
should
focus
developing
selective
biomarkers,
optimizing
therapeutic
interventions,
exploring
the
immune
regulation.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 838 - 838
Published: Feb. 28, 2025
This
study
evaluates
the
effects
of
fortifying
bread
with
different
concentrations
(3%,
10%,
and
30%)
Matricaria
chamomilla
L.
(MC)
infusion
powder,
derived
from
plant's
aerial
parts
(stem,
leaf,
flower).
UPLC/MS-MS
analysis
MC
powder
ethanolic
extract
confirmed
presence
polyphenolic
compounds,
including
flavonoids,
contributing
to
enhanced
antioxidant
enzyme
inhibitory
properties.
The
physicochemical,
antioxidant,
sensory
properties
enriched
breads
were
assessed.
Hierarchical
cluster
revealed
that
30%
(BP-MC
(BI-MC
exhibited
superior
overall
quality
compared
other
formulations.
showed
increased
protein,
fiber,
content.
Specifically,
BI-MC
demonstrated
activity,
while
BP-MC
provided
highest
fiber
Sensory
evaluation
indicated
retained
similar
those
control
bread,
despite
nutritional
improvements.
These
findings
suggest
incorporating
chamomilla,
particularly
at
30%,
enhances
profile
maintaining
characteristics
close
traditional
bread.
research
highlights
potential
using
chamomile's
in
valorization
plant-based
by-products
for
functional
bakery
product
development.
Compounds,
Journal Year:
2024,
Volume and Issue:
4(3), P. 479 - 502
Published: Aug. 12, 2024
Cardiovascular
diseases
(CVDs)
are
a
global
health
problem.
The
mortality
associated
with
them
is
one
of
the
highest.
Essentially,
CVDs
occur
when
heart
or
blood
vessels
damaged.
Oxidative
stress
an
imbalance
between
production
reactive
oxygen
species
(free
radicals)
and
antioxidant
defenses.
Increased
can
cause
cardiac
vascular
injuries,
leading
to
CVDs.
Antioxidant
therapy
has
been
shown
have
beneficial
effects
on
Plants
rich
source
bioactive
antioxidants
our
planet.
Several
classes
these
compounds
identified.
Among
them,
carotenoids
phenolic
most
potent
antioxidants.
This
review
summarizes
role
some
(a/β-carotene,
lycopene
lutein),
polyphenols
such
as
acids
(caffeic,
p-coumaric,
ferulic
chlorogenic
acids),
flavonoids
(quercetin,
kaempferol
epigallocatechin
gallate),
hydroxytyrosol
in
mitigating
by
studying
their
biological
mechanisms.
Through
detailed
analysis,
we
aim
provide
deeper
understanding
how
natural
be
integrated
into
cardiovascular
strategies
help
reduce
overall
burden
CVD.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(7), P. 1430 - 1430
Published: July 15, 2023
OSAS
is
a
disease
that
affects
2%
of
men
and
4%
women
middle
age.
It
major
health
public
problem
because
untreated
could
lead
to
cardiovascular,
metabolic,
cerebrovascular
complications.
The
more
accepted
theory
relates
oxidative
stress
due
intermittent
hypoxia,
which
leads,
after
an
intense
inflammatory
response
through
multiple
pathways,
endothelial
damage.
objective
this
study
demonstrate
correlation
between
hearing
loss,
the
effect
CPAP
on
function,
if
also
involved
in
damaging
system.A
review
literature
has
been
executed.
Eight
articles
have
found,
where
seven
were
about
system,
only
one
was
effects.
noted
two
eight
explored
hypoxia.All
studies
showed
significant
function
(p
<
0.05).Untreated
system
at
levels.
Oxidative
hypoxia
main
pathogenetic
mechanism
no
effects
(positive
or
negative)
function.
More
are
needed,
with
evaluation
extended
high
frequencies,
execution
vocal
audiometry
noisy
environments,
potential
biomarkers
stress.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 11, 2024
ABSTRACT
Our
bodies
are
constantly
exposed
to
or
producing
free
radicals
nearly
on
a
daily
basis.
These
highly
reactive
molecules
generated
through
variety
of
internal
and
external
processes
pathways
within
the
body.
If
these
not
neutralized
by
antioxidants,
they
can
lead
state
oxidative
stress,
which
has
been
linked
wide
range
severe
debilitating
disorders
affecting
various
systems
in
human
This
involves
neurodegenerative
diseases,
diabetes,
atherosclerosis,
fatty
liver,
inflammation,
aging.
Thankfully,
body
is
armed
with
repertoire
powerful
antioxidants
different
natures
modes
action.
The
recent
decades
witnessed
publication
enormous
papers
proving
antioxidant
activity
novel
synthesized
compound,
plant
extract,
purified
drug
vitro,
vivo,
even
beings.
However,
efficacy
therapies
clinical
trials,
including
selenium,
vitamin
C,
E,
A,
notably
inconsistent.
inconsistency
be
primarily
ascribed
factors
related
nature
radical
generation,
purpose
specific
type
therapy
employed,
intricate
stress
connected
network,
among
others.
Collectively,
will
explored
this
review
article
decipher
observed
shortcomings
application
settings.
