The determination of fibroblast and keratinocyte death types after their transplantation into γ-irradiated porous scaffold in vitro DOI Creative Commons
Yurii Kot, Kateryna Kot,

Рашад Афатович Курбанов

et al.

Regulatory Mechanisms in Biosystems, Journal Year: 2023, Volume and Issue: 14(4), P. 552 - 558

Published: Oct. 18, 2023

In the course of radiation therapy, normal cells surrounding tumor are also irradiated. During and after irradiation, they undergo a series structural metabolic changes, which can lead to cell death or transformation. Therefore, when planning conducting effects on taken into account with aim predicting further correcting post-radiation complications, including development burns ulcers. Radiation skin characterized by prolonged wound healing process, is accompanied sharp decrease in number viable affected tissue from first hours irradiation. The type significantly impact effectiveness therapy complication correction. it important study their irradiated three-dimensional culture model dermal equivalent, widely used today for modeling biological processes. To detect pathways death, levels reactive oxygen species, viability, undergoing autophagy, apoptosis, necrosis, content active caspases 3, 8, 9 was fluorometrically measured 3D laser scanning confocal microscopy. It determined that transplantation fibroblasts keratinocytes equivalent contributed an increase overall viability led significant concentration free forms equivalent. Cells within were not evenly distributed terms quantity count over time. A cluster higher formed around transplant. At same time, transplant found be more resistant cytotoxic factors post-irradiation environment compared keratinocytes. demonstrated non-irradiated predominantly through primarily introduction transplant, occurs apoptosis. culture, both without transplantation, there effector caspase 3. apoptosis mitochondrial mechanism (with predominance 9), while receptor-mediated dominates 8). obtained results new effective methods burns, chronic ulcers wounds various etiologies.

Language: Английский

Endothelial dysfunction in chronic obstructive pulmonary disease: an update on mechanisms, assessment tools and treatment strategies DOI Creative Commons
Giuseppina Marcuccio, Claudio Candia, Mauro Maniscalco

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 12, 2025

Chronic obstructive pulmonary disease (COPD) is a complex condition marked by chronic respiratory symptoms, such as cough and dyspnoea, persistent irreversible airway obstruction, punctuated acute episodes of exacerbations. COPD associated with significant mortality risk several comorbidities, including cardiovascular diseases. The link between COPD, exacerbations diseases has been recently acknowledged under the unifying concept cardiopulmonary risk. In this context, endothelial dysfunction (ED) identified key contributor to systemic manifestations an early event in atherogenesis, thus potentially linking Assessing could therefore provide valuable prognostic insights into while targeting it may emerge promising therapeutic approach. Nonetheless, aspects clinical assessment options potential treatment strategies are still debate, despite intense research activity recent years results coming from field rehabilitation medicine, which seems be highly beneficial for improvement ED patients. On these premises, mini review aims updated overview pathophysiology context focus on its attractive target.

Language: Английский

Citations

1
Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges DOI Creative Commons

Sofia Kokkinis,

Manisha Singh, Keshav Raj Paudel

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103761 - 103761

Published: Feb. 16, 2024

Chronic obstructive pulmonary disease (COPD) is a widespread global health problem marked by increasing airflow limitation and chronic airway inflammation. Conventional treatments for COPD offer limited efficacy have potentially undesirable effects, requiring the investigation of other therapeutic options. Because their anti-inflammatory, antioxidant, bronchodilatory plant-based chemicals emerged as viable candidates therapy. The successful delivery these compounds to respiratory system, on hand, remains an enormous challenge. This extensive review article explores promising potential therapies investigates leading-edge nanoformulation technologies targeted at addressing complex challenges that accompany natural compounds. We discuss multiple plant-derived (polyphenols, flavonoids, alkaloids) modes action in reducing COPD-related indications complications. Additionally, function nanotechnology improving bioavailability, stability, pharmaceuticals treatment explored. Nanoformulation techniques, such nanoparticles, liposomes, micelles, are described, with emphasis precisely encapsulate transport bioactive afflicted parts lung. Furthermore, constraints development nanoformulations also highlighted, including safety, scalability, regulatory issues. current aims provide thorough understanding future combining knowledge novel technologies. intersection nature-inspired medicines may hold key more effective, safer, patient-centred choices people suffering from this illness.

Language: Английский

Citations

4
The Role of Exhaled Breath Condensate in Chronic Inflammatory and Neoplastic Diseases of the Respiratory Tract DOI Open Access
Karolina Kita-Milczarska, Marika Gawinowska, Marta Chełmińska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7395 - 7395

Published: July 5, 2024

Asthma and chronic obstructive pulmonary disease (COPD) are among the most common respiratory diseases. Chronic inflammation of airways leads to an increased production inflammatory markers by effector cells tract lung tissue. These biomarkers allow assessment physiological pathological processes responses therapeutic interventions. Lung cancer, which is characterized high mortality, one frequently diagnosed cancers worldwide. Current screening methods tissue biopsies have limitations that highlight need for rapid diagnosis, patient differentiation, effective management monitoring. One promising non-invasive diagnostic method diseases exhaled breath condensate (EBC). EBC contains a mixture volatile non-volatile such as cytokines, leukotrienes, oxidative stress markers, molecular biomarkers, providing significant information about neoplastic states in lungs. This article summarizes research on application development diagnosing monitoring diseases, focusing asthma, COPD, cancer. The process collecting condensate, potential issues, selected groups detailed future discussed. Further may contribute more precise personalized treatment methods.

Language: Английский

Citations

4
Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis—A Narrative Review DOI Open Access

Oana Maria Catana,

Alexandra Floriana Nemeş,

Ramona Cioboată

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2611 - 2611

Published: April 10, 2025

Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition characterized by airflow limitations systemic inflammation. The interaction between the metabolic inflammatory pathways plays key role in progression, with leptin insulin emerging as pivotal regulators. Leptin, an adipokine that regulates energy homeostasis, insulin, primary regulator of glucose metabolism, are both altered COPD patients. This narrative review provides in-depth examination roles pathogenesis, focusing on molecular mechanisms through which these regulators interact how their dysregulation contributes to spectrum extrapulmonary manifestations. These disturbances not only exacerbate symptoms but also increase risk comorbidities such syndrome, diabetes, cardiovascular disease, or muscle wasting. By exploring underlying COPD, this underscores significance metabolic-inflammatory axis, suggesting restoring balance modulation could offer novel therapeutic strategies for improving clinical outcomes.

Language: Английский

Citations

0
PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis DOI Creative Commons
Mario Cazzola, Clive P. Page, Paola Rogliani

et al.

Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
The Association Between Systemic Immune-Inflammation Index and Cardiovascular Diseases: An In-depth Umbrella Review of Meta-Analyses with Grade Assessment DOI Creative Commons
Ehsan Amini‐Salehi,

Nimra Shafi,

Rafael Contreras

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42736 - e42736

Published: Feb. 1, 2025

Language: Английский

Citations

0
Role of Serum and Dietary Vitamins A and E in Pulmonary Function and Chronic Obstructive Pulmonary Disease: A Systematic Review DOI Creative Commons

Shabina Saifullah,

Amna Ihsan,

Syed Wajahat Ali Shah

et al.

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Chronic Obstructive Pulmonary Disease (COPD) is a major global health concern, significantly affecting quality of life and healthcare systems. Oxidative stress plays critical role in COPD pathogenesis. Vitamins A E, as fat-soluble antioxidants, are believed to support pulmonary health, but studies report conflicting findings. Objectives: To evaluate associations between serum dietary concentrations vitamins E with function parameters risk or severity, this systematic review was conducted. Methods: search conducted PubMed, EMBASE, Scopus, the Cochrane Library. Of 150 screened studies, 22 met inclusion criteria, comprising cross-sectional, cohort, case-control, interventional designs. Studies assessing levels their relationships (FEV₁, FVC, FEV₁/FVC) were included. Results: Higher vitamin linked improved FEV₁ FVC reduced prevalence. Vitamin intake associated lower COPD, though its effects on lung varied. Supplementation showed mixed results, benefits observed mainly when combined other antioxidants. Effects more pronounced smokers individuals systemic inflammation. Conclusions: particularly A, may slow progression. However, inconsistencies highlighted need for well-designed trials confirm management.

Language: Английский

Citations

0
The influence of uremic toxins on low bone turnover disease in chronic kidney disease DOI Creative Commons
Giou‐Teng Yiang, Wen‐Lin Su, Cai‐Mei Zheng

et al.

Tzu Chi Medical Journal, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 13, 2023

A BSTRACT Uremic toxins play a crucial role in the development of low bone turnover disease chronic kidney (CKD) through induction oxidative stress. This stress disrupts delicate balance between formation and resorption, resulting decline both quantity quality. Reactive oxygen species (ROS) activate nuclear factor kappa-B mitogen-activated protein kinase signaling pathways, promoting osteoclastogenesis. Conversely, ROS hinder osteoblast differentiation by facilitating binding Forkhead box O proteins (FoxOs) to β-catenin, triggering apoptosis FoxOs-activating phosphorylation. results increased osteoblastic receptor activator ligand (RANKL) expression decreased erythroid 2-related 2 levels, compromising antioxidant defenses against damage. As CKD progresses, accumulation protein-bound uremic such as indoxyl sulfate (IS) p-cresyl (PCS) intensifies stress, primarily affecting osteoblasts. IS PCS directly inhibit viability, induce apoptosis, decrease alkaline phosphatase activity, impair collagen 1 osteonectin, impeding formation. They also reduce cyclic adenosine 3’,5’-monophosphate (cAMP) production lower parathyroid hormone (PTH) osteoblasts, PTH hyporesponsiveness. In summary, excessive not only reduces number function osteoblasts but induces hyporesponsiveness, contributing initiation progression CKD.

Language: Английский

Citations

4
Exercise-Induced Oxygen Desaturation Increases Arterial Stiffness in Patients with COPD During the 6WMT DOI Creative Commons
Siyuan Wang, Beiyao Gao, Minghui Shi

et al.

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 1479 - 1489

Published: June 1, 2024

Objective: Given the established impact of exercise in reducing arterial stiffness and potential for intermittent hypoxia to induce its elevation, this study aims understand how oxygen desaturation during affects individuals with COPD. Methods: We enrolled patients stable COPD from China-Japan Friendship Hospital November 2022 June 2023. The 6-minute walk test (6-MWT) was performed continuous blood saturation (SpO 2 ) monitoring these patients. were classified into three groups: non-exercise induced (EID), mild-EID severe-EID, according changes SpO 6-MWT. Cardio-Ankle Vascular Index (CAVI) change CAVI (ΔCAVI, calculated as before 6MWT minus after 6MWT) measured immediately assess acute effects on stiffness. GOLD Stage, pulmonary function, other functional outcomes also study. Results: A total 37 underwent evaluation (ΔCAVI) Stratification based revealed subgroups: non-EID (n=12), (n=15), severe-EID (n=10). ΔCAVI values − 0.53 (− 0.95 0.31) group, 0.20 1.45 0.50) 0.6 (0.08 0.73) group. Parametric tests indicated significant differences among EID groups (p = 0.005). Pairwise comparisons demonstrated distinctions between groups, well 0.048 p 0.003, respectively). Multivariable analysis, adjusting age, sex, stage, diffusion capacity, pressure, identified an independent factor associated (B 1.118, 0.038). Conclusion: Patients may experience worsening even short periods exercise. Keywords: COPD, stiffness, exercise-induced desaturation, rehabilitation

Language: Английский

Citations

1
Co-Morbidity Clusters in Post-COVID-19 Syndrome DOI Open Access

Anna Sárközi,

Ilona Tornyi,

Erik Békési

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1457 - 1457

Published: March 2, 2024

Background: Post-COVID-19 syndrome, characterized by persistent symptoms emerging more than 12 weeks after acute infection, displays diverse manifestations. This study aimed to analyze co-existing organ dysfunctions in post-COVID-19 patients and explore their potential association with the COVID-19 episode functional impairment. Methods: Data from 238 attending outpatient care between 1 March 2021 2022, previous hospitalization for COVID-19, were retrospectively analyzed 80 having comprehensive mapping of involvement. Results: The average time was 149 days. Spirometry indicated significant abnormalities lung function. Predominant included respiratory (75%), fatigue (73%), neurological (62.5%), ear-nose-throat issues (51.25%). Multiorgan observed 87.5% patients, contributing an 18.33% reduction health quality compared pre-acute levels. Subgroup analysis identified four distinct syndrome subgroups, highlighting coexistence disorders as indicators drivers further Our results reveal that most suffer multiorgan disorders. Conclusions: presence coexisting suggests involvement other systems well. complexity requires studies provide insights into different symptom clusters identify targets personalized preventive therapeutic interventions improve patient outcome.

Language: Английский

Citations

1