Regulatory Mechanisms in Biosystems,
Journal Year:
2023,
Volume and Issue:
14(4), P. 552 - 558
Published: Oct. 18, 2023
In
the
course
of
radiation
therapy,
normal
cells
surrounding
tumor
are
also
irradiated.
During
and
after
irradiation,
they
undergo
a
series
structural
metabolic
changes,
which
can
lead
to
cell
death
or
transformation.
Therefore,
when
planning
conducting
effects
on
taken
into
account
with
aim
predicting
further
correcting
post-radiation
complications,
including
development
burns
ulcers.
Radiation
skin
characterized
by
prolonged
wound
healing
process,
is
accompanied
sharp
decrease
in
number
viable
affected
tissue
from
first
hours
irradiation.
The
type
significantly
impact
effectiveness
therapy
complication
correction.
it
important
study
their
irradiated
three-dimensional
culture
model
dermal
equivalent,
widely
used
today
for
modeling
biological
processes.
To
detect
pathways
death,
levels
reactive
oxygen
species,
viability,
undergoing
autophagy,
apoptosis,
necrosis,
content
active
caspases
3,
8,
9
was
fluorometrically
measured
3D
laser
scanning
confocal
microscopy.
It
determined
that
transplantation
fibroblasts
keratinocytes
equivalent
contributed
an
increase
overall
viability
led
significant
concentration
free
forms
equivalent.
Cells
within
were
not
evenly
distributed
terms
quantity
count
over
time.
A
cluster
higher
formed
around
transplant.
At
same
time,
transplant
found
be
more
resistant
cytotoxic
factors
post-irradiation
environment
compared
keratinocytes.
demonstrated
non-irradiated
predominantly
through
primarily
introduction
transplant,
occurs
apoptosis.
culture,
both
without
transplantation,
there
effector
caspase
3.
apoptosis
mitochondrial
mechanism
(with
predominance
9),
while
receptor-mediated
dominates
8).
obtained
results
new
effective
methods
burns,
chronic
ulcers
wounds
various
etiologies.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 12, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
complex
condition
marked
by
chronic
respiratory
symptoms,
such
as
cough
and
dyspnoea,
persistent
irreversible
airway
obstruction,
punctuated
acute
episodes
of
exacerbations.
COPD
associated
with
significant
mortality
risk
several
comorbidities,
including
cardiovascular
diseases.
The
link
between
COPD,
exacerbations
diseases
has
been
recently
acknowledged
under
the
unifying
concept
cardiopulmonary
risk.
In
this
context,
endothelial
dysfunction
(ED)
identified
key
contributor
to
systemic
manifestations
an
early
event
in
atherogenesis,
thus
potentially
linking
Assessing
could
therefore
provide
valuable
prognostic
insights
into
while
targeting
it
may
emerge
promising
therapeutic
approach.
Nonetheless,
aspects
clinical
assessment
options
potential
treatment
strategies
are
still
debate,
despite
intense
research
activity
recent
years
results
coming
from
field
rehabilitation
medicine,
which
seems
be
highly
beneficial
for
improvement
ED
patients.
On
these
premises,
mini
review
aims
updated
overview
pathophysiology
context
focus
on
its
attractive
target.
Food Bioscience,
Journal Year:
2024,
Volume and Issue:
58, P. 103761 - 103761
Published: Feb. 16, 2024
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
widespread
global
health
problem
marked
by
increasing
airflow
limitation
and
chronic
airway
inflammation.
Conventional
treatments
for
COPD
offer
limited
efficacy
have
potentially
undesirable
effects,
requiring
the
investigation
of
other
therapeutic
options.
Because
their
anti-inflammatory,
antioxidant,
bronchodilatory
plant-based
chemicals
emerged
as
viable
candidates
therapy.
The
successful
delivery
these
compounds
to
respiratory
system,
on
hand,
remains
an
enormous
challenge.
This
extensive
review
article
explores
promising
potential
therapies
investigates
leading-edge
nanoformulation
technologies
targeted
at
addressing
complex
challenges
that
accompany
natural
compounds.
We
discuss
multiple
plant-derived
(polyphenols,
flavonoids,
alkaloids)
modes
action
in
reducing
COPD-related
indications
complications.
Additionally,
function
nanotechnology
improving
bioavailability,
stability,
pharmaceuticals
treatment
explored.
Nanoformulation
techniques,
such
nanoparticles,
liposomes,
micelles,
are
described,
with
emphasis
precisely
encapsulate
transport
bioactive
afflicted
parts
lung.
Furthermore,
constraints
development
nanoformulations
also
highlighted,
including
safety,
scalability,
regulatory
issues.
current
aims
provide
thorough
understanding
future
combining
knowledge
novel
technologies.
intersection
nature-inspired
medicines
may
hold
key
more
effective,
safer,
patient-centred
choices
people
suffering
from
this
illness.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7395 - 7395
Published: July 5, 2024
Asthma
and
chronic
obstructive
pulmonary
disease
(COPD)
are
among
the
most
common
respiratory
diseases.
Chronic
inflammation
of
airways
leads
to
an
increased
production
inflammatory
markers
by
effector
cells
tract
lung
tissue.
These
biomarkers
allow
assessment
physiological
pathological
processes
responses
therapeutic
interventions.
Lung
cancer,
which
is
characterized
high
mortality,
one
frequently
diagnosed
cancers
worldwide.
Current
screening
methods
tissue
biopsies
have
limitations
that
highlight
need
for
rapid
diagnosis,
patient
differentiation,
effective
management
monitoring.
One
promising
non-invasive
diagnostic
method
diseases
exhaled
breath
condensate
(EBC).
EBC
contains
a
mixture
volatile
non-volatile
such
as
cytokines,
leukotrienes,
oxidative
stress
markers,
molecular
biomarkers,
providing
significant
information
about
neoplastic
states
in
lungs.
This
article
summarizes
research
on
application
development
diagnosing
monitoring
diseases,
focusing
asthma,
COPD,
cancer.
The
process
collecting
condensate,
potential
issues,
selected
groups
detailed
future
discussed.
Further
may
contribute
more
precise
personalized
treatment
methods.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(8), P. 2611 - 2611
Published: April 10, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
progressive
and
debilitating
condition
characterized
by
airflow
limitations
systemic
inflammation.
The
interaction
between
the
metabolic
inflammatory
pathways
plays
key
role
in
progression,
with
leptin
insulin
emerging
as
pivotal
regulators.
Leptin,
an
adipokine
that
regulates
energy
homeostasis,
insulin,
primary
regulator
of
glucose
metabolism,
are
both
altered
COPD
patients.
This
narrative
review
provides
in-depth
examination
roles
pathogenesis,
focusing
on
molecular
mechanisms
through
which
these
regulators
interact
how
their
dysregulation
contributes
to
spectrum
extrapulmonary
manifestations.
These
disturbances
not
only
exacerbate
symptoms
but
also
increase
risk
comorbidities
such
syndrome,
diabetes,
cardiovascular
disease,
or
muscle
wasting.
By
exploring
underlying
COPD,
this
underscores
significance
metabolic-inflammatory
axis,
suggesting
restoring
balance
modulation
could
offer
novel
therapeutic
strategies
for
improving
clinical
outcomes.
Pakistan Journal of Health Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Chronic
Obstructive
Pulmonary
Disease
(COPD)
is
a
major
global
health
concern,
significantly
affecting
quality
of
life
and
healthcare
systems.
Oxidative
stress
plays
critical
role
in
COPD
pathogenesis.
Vitamins
A
E,
as
fat-soluble
antioxidants,
are
believed
to
support
pulmonary
health,
but
studies
report
conflicting
findings.
Objectives:
To
evaluate
associations
between
serum
dietary
concentrations
vitamins
E
with
function
parameters
risk
or
severity,
this
systematic
review
was
conducted.
Methods:
search
conducted
PubMed,
EMBASE,
Scopus,
the
Cochrane
Library.
Of
150
screened
studies,
22
met
inclusion
criteria,
comprising
cross-sectional,
cohort,
case-control,
interventional
designs.
Studies
assessing
levels
their
relationships
(FEV₁,
FVC,
FEV₁/FVC)
were
included.
Results:
Higher
vitamin
linked
improved
FEV₁
FVC
reduced
prevalence.
Vitamin
intake
associated
lower
COPD,
though
its
effects
on
lung
varied.
Supplementation
showed
mixed
results,
benefits
observed
mainly
when
combined
other
antioxidants.
Effects
more
pronounced
smokers
individuals
systemic
inflammation.
Conclusions:
particularly
A,
may
slow
progression.
However,
inconsistencies
highlighted
need
for
well-designed
trials
confirm
management.
Tzu Chi Medical Journal,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 13, 2023
A
BSTRACT
Uremic
toxins
play
a
crucial
role
in
the
development
of
low
bone
turnover
disease
chronic
kidney
(CKD)
through
induction
oxidative
stress.
This
stress
disrupts
delicate
balance
between
formation
and
resorption,
resulting
decline
both
quantity
quality.
Reactive
oxygen
species
(ROS)
activate
nuclear
factor
kappa-B
mitogen-activated
protein
kinase
signaling
pathways,
promoting
osteoclastogenesis.
Conversely,
ROS
hinder
osteoblast
differentiation
by
facilitating
binding
Forkhead
box
O
proteins
(FoxOs)
to
β-catenin,
triggering
apoptosis
FoxOs-activating
phosphorylation.
results
increased
osteoblastic
receptor
activator
ligand
(RANKL)
expression
decreased
erythroid
2-related
2
levels,
compromising
antioxidant
defenses
against
damage.
As
CKD
progresses,
accumulation
protein-bound
uremic
such
as
indoxyl
sulfate
(IS)
p-cresyl
(PCS)
intensifies
stress,
primarily
affecting
osteoblasts.
IS
PCS
directly
inhibit
viability,
induce
apoptosis,
decrease
alkaline
phosphatase
activity,
impair
collagen
1
osteonectin,
impeding
formation.
They
also
reduce
cyclic
adenosine
3’,5’-monophosphate
(cAMP)
production
lower
parathyroid
hormone
(PTH)
osteoblasts,
PTH
hyporesponsiveness.
In
summary,
excessive
not
only
reduces
number
function
osteoblasts
but
induces
hyporesponsiveness,
contributing
initiation
progression
CKD.
International Journal of COPD,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1479 - 1489
Published: June 1, 2024
Objective:
Given
the
established
impact
of
exercise
in
reducing
arterial
stiffness
and
potential
for
intermittent
hypoxia
to
induce
its
elevation,
this
study
aims
understand
how
oxygen
desaturation
during
affects
individuals
with
COPD.
Methods:
We
enrolled
patients
stable
COPD
from
China-Japan
Friendship
Hospital
November
2022
June
2023.
The
6-minute
walk
test
(6-MWT)
was
performed
continuous
blood
saturation
(SpO
2
)
monitoring
these
patients.
were
classified
into
three
groups:
non-exercise
induced
(EID),
mild-EID
severe-EID,
according
changes
SpO
6-MWT.
Cardio-Ankle
Vascular
Index
(CAVI)
change
CAVI
(ΔCAVI,
calculated
as
before
6MWT
minus
after
6MWT)
measured
immediately
assess
acute
effects
on
stiffness.
GOLD
Stage,
pulmonary
function,
other
functional
outcomes
also
study.
Results:
A
total
37
underwent
evaluation
(ΔCAVI)
Stratification
based
revealed
subgroups:
non-EID
(n=12),
(n=15),
severe-EID
(n=10).
ΔCAVI
values
−
0.53
(−
0.95
0.31)
group,
0.20
1.45
0.50)
0.6
(0.08
0.73)
group.
Parametric
tests
indicated
significant
differences
among
EID
groups
(p
=
0.005).
Pairwise
comparisons
demonstrated
distinctions
between
groups,
well
0.048
p
0.003,
respectively).
Multivariable
analysis,
adjusting
age,
sex,
stage,
diffusion
capacity,
pressure,
identified
an
independent
factor
associated
(B
1.118,
0.038).
Conclusion:
Patients
may
experience
worsening
even
short
periods
exercise.
Keywords:
COPD,
stiffness,
exercise-induced
desaturation,
rehabilitation
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(5), P. 1457 - 1457
Published: March 2, 2024
Background:
Post-COVID-19
syndrome,
characterized
by
persistent
symptoms
emerging
more
than
12
weeks
after
acute
infection,
displays
diverse
manifestations.
This
study
aimed
to
analyze
co-existing
organ
dysfunctions
in
post-COVID-19
patients
and
explore
their
potential
association
with
the
COVID-19
episode
functional
impairment.
Methods:
Data
from
238
attending
outpatient
care
between
1
March
2021
2022,
previous
hospitalization
for
COVID-19,
were
retrospectively
analyzed
80
having
comprehensive
mapping
of
involvement.
Results:
The
average
time
was
149
days.
Spirometry
indicated
significant
abnormalities
lung
function.
Predominant
included
respiratory
(75%),
fatigue
(73%),
neurological
(62.5%),
ear-nose-throat
issues
(51.25%).
Multiorgan
observed
87.5%
patients,
contributing
an
18.33%
reduction
health
quality
compared
pre-acute
levels.
Subgroup
analysis
identified
four
distinct
syndrome
subgroups,
highlighting
coexistence
disorders
as
indicators
drivers
further
Our
results
reveal
that
most
suffer
multiorgan
disorders.
Conclusions:
presence
coexisting
suggests
involvement
other
systems
well.
complexity
requires
studies
provide
insights
into
different
symptom
clusters
identify
targets
personalized
preventive
therapeutic
interventions
improve
patient
outcome.