Endocrines,
Journal Year:
2024,
Volume and Issue:
5(2), P. 225 - 243
Published: May 22, 2024
Resveratrol
is
a
natural
polyphenol
with
important
anti-inflammatory
and
antioxidant
properties
for
treating
cardiometabolic
disorders.
Therefore,
the
present
meta-analysis
aimed
to
review
investigate
oral
resveratrol
supplementation
effects
on
metabolic
syndrome
(MetS)
components.
The
bibliographic
search
was
carried
out
in
2023
following
databases:
PubMed,
Web
of
Science,
Scopus.
Studies
that
investigated
MetS
parameters
were
included.
Statistical
analyses
performed
using
RevMan
Software
V.5.3.
main
findings
showed
significantly
decreased
systolic
diastolic
blood
pressure
while
having
no
significant
waist
circumference
high-density
lipoprotein
levels.
In
addition,
glucose
level
subgroup
studies
reporting
change
from
baseline
means,
although
overall
effect
not
statistically
(p
=
0.81),
triglyceride
levels
increased
after
treatment
period.
conclusion,
evidenced
potential
therapeutic
improving
some
features,
especially
regarding
pressure,
reduction;
however,
results
are
still
borderline
sometimes
controversial,
which
might
be
justified
by
methodological
statistical
heterogeneity
studies,
latter
varying
17
57%.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 942 - 942
Published: Aug. 2, 2024
We
aimed
to
investigate
the
role
of
capsaicin
(CAP)
in
modulating
lipopolysaccharide
(LPS)-induced
hepatic
and
intestinal
inflammation,
oxidative
stress,
its
colonic
microflora
mice.
Thirty
healthy
male
Kunming
mice
with
similar
body
weights
were
randomly
assigned
three
groups:
control
group
(CON),
LPS
group,
CAP
ten
each
group.
The
CON
groups
received
a
daily
dose
normal
saline,
respectively,
while
an
equivalent
CAP.
On
28th
day
experiment,
intraperitoneally
injected
LPS,
was
equal
volume
saline.
results
lead
following
conclusions.
Compared
improved
loss
lobular
structure
significantly
increased
duodenal
villus
length
ratio
crypt
depth.
colon
interleukin-10
(IL-10)
decreased
IL-6,
IL-1β,
tumor
necrosis
factor
(TNF-α)
levels.
also
catalase
(CAT),
glutathione
peroxidase
(GSH-Px),
superoxide
dismutase
(SOD)
expression,
malondialdehyde
(MDA)
relative
abundances
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(8), P. 1031 - 1031
Published: Aug. 19, 2024
Oxidative
stress
is
a
key
factor
in
the
pathological
processes
that
trigger
various
chronic
liver
diseases,
and
significantly
contributes
to
development
of
hepatocarcinogenesis.
Natural
antioxidants
reduce
oxidative
by
neutralizing
free
radicals
play
crucial
role
treatment
free-radical-induced
diseases.
However,
their
efficacy
often
limited
poor
bioavailability
metabolic
stability.
To
address
these
limitations,
recent
advances
have
focused
on
developing
nano-drug
delivery
systems
protect
them
from
degradation
enhance
therapeutic
potential.
Among
several
critical
benefits,
they
showed
be
able
improve
targeted
delivery,
thereby
reducing
off-target
effects
specifically
directing
antioxidant
tumor
site.
Moreover,
nanosystems
led
sustained
release,
prolonging
effect
over
time.
Some
also
exhibited
synergistic
when
combined
with
other
agents,
allowing
for
improved
overall
efficacy.
This
review
aims
discuss
scientific
nano-formulations
containing
natural
molecules,
highlighting
potential
as
promising
approaches
cancer.
The
novelty
this
lies
its
comprehensive
focus
latest
developments
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 14148 - 14148
Published: Sept. 15, 2023
Oxidative
stress
is
a
common
phenomenon
of
many
liver
disorders;
it
both
affects
patient
survival
and
directly
influences
the
applicability,
effectiveness,
toxicity
drugs.
In
pursuit
reliable
natural
remedies
for
hepatoprotection,
this
study
reports
on
complete
phytochemical
characterization,
antioxidant,
hepatoprotective
activities
Prenanthes
purpurea
methanol-aqueous
extract
in
an
vitro
model
diclofenac-induced
injury
(DILI).
An
ultra
high-performance
liquid
chromatography-high-resolution
mass
spectrometry
analysis
(UHPLC-HRMS)
was
conducted,
delineating
more
than
100
secondary
metabolites
first
time
species,
including
series
phenolic
acid-hexosides,
acylquinic,
acylhydroxyquinic
acyltartaric
acids,
flavonoids.
Quinic
acid,
chlorogenic,
3,5-dicaffeoylquinic
5-feruloylhydroxyquinic
caffeoyltartaric
cichoric
eryodictiol-O-hexuronide,
luteolin
O-hexuronide
dominated
profile
most
likely
contributed
to
observed
activity
studied
P.
leaf
extract.
The
potency
molecular
basis
cellular
protection
were
investigated
parallel
with
pure
caffeoylquinic
acids
pretreatment
experiments
that
verified
antiapoptotic
antioxidant
properties
products.
Endocrines,
Journal Year:
2024,
Volume and Issue:
5(2), P. 225 - 243
Published: May 22, 2024
Resveratrol
is
a
natural
polyphenol
with
important
anti-inflammatory
and
antioxidant
properties
for
treating
cardiometabolic
disorders.
Therefore,
the
present
meta-analysis
aimed
to
review
investigate
oral
resveratrol
supplementation
effects
on
metabolic
syndrome
(MetS)
components.
The
bibliographic
search
was
carried
out
in
2023
following
databases:
PubMed,
Web
of
Science,
Scopus.
Studies
that
investigated
MetS
parameters
were
included.
Statistical
analyses
performed
using
RevMan
Software
V.5.3.
main
findings
showed
significantly
decreased
systolic
diastolic
blood
pressure
while
having
no
significant
waist
circumference
high-density
lipoprotein
levels.
In
addition,
glucose
level
subgroup
studies
reporting
change
from
baseline
means,
although
overall
effect
not
statistically
(p
=
0.81),
triglyceride
levels
increased
after
treatment
period.
conclusion,
evidenced
potential
therapeutic
improving
some
features,
especially
regarding
pressure,
reduction;
however,
results
are
still
borderline
sometimes
controversial,
which
might
be
justified
by
methodological
statistical
heterogeneity
studies,
latter
varying
17
57%.
