Grains in a Modern Time: A Comprehensive Review of Compositions and Understanding Their Role in Type 2 Diabetes and Cancer DOI Creative Commons

Jabir Khan,

Palwasha Gul,

Kunlun Liu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2112 - 2112

Published: July 2, 2024

Globally, type 2 diabetes (T2D) and Cancer are the major causes of morbidity mortality worldwide considered to be two most significant public health concerns 21st century. Over next decades, global burden is expected increase by approximately 60%. Several observational studies as well clinical trials have demonstrated benefits consuming whole grains lower risk several chronic non-communicable diseases including T2D cancer. Cereals primary source energy in human diet. The widely consumed pseudo cereals include (quinoa, amaranth, buckwheat) (wheat, rice, corn). From a nutritional perspective, both recognized for their complete protein, essential amino acids, dietary fibers, phenolic acids. bran layer seed contains majority these components. Greater intake rather than refined has been consistently linked Due superior compositions, make them preferred choice over grains. modulatory effects on cancer also likely influenced mechanisms; some may direct while others involve altering composition gut microbiota, increasing abundance beneficial bacteria, lowering harmful insulin sensitivity, solubility free bile breaking protein down into peptides producing short-chain fatty acids (SCFAs), other metabolites that promote proliferation colon which modulate antidiabetic anticancer pathway. Thus, present review had aims. First, it summarized recent knowledge about bioactive corn); second section discussed progress studies, such (cross-sectional case-control cohort studies) intervention understand role potential mechanism. Overall, according scientific data, grain consumption reduce incidence Future should carry out randomized controlled validate results establish causality. In addition, current manuscript encourages researchers investigate specific mechanisms exert examining different types might help prevent or treat

Language: Английский

Functional iridoid synthases from iridoid producing and non-producing Nepeta species (subfam. Nepetoidae, fam. Lamiaceae) DOI Creative Commons
Neda Aničić, Dragana Matekalo, Marijana Škorić

et al.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

Iridoids, a class of atypical monoterpenes, exhibit exceptional diversity within the Nepeta genus (subfam. Nepetoidae, fam. Lamiaceae).The majority these plants produce iridoids unique stereochemistry, with nepetalactones (NLs) predominating; however, few species lack compounds. By comparatively analyzing metabolomics, transcriptomics, gene co-expression, and phylogenetic data iridoid-producing N. rtanjensis Diklić & Milojević iridoid-lacking nervosa Royle Bentham, we presumed that one factors responsible for absence compounds in is iridoid synthase (ISY). Two orthologues ISY were mined from leaves transcriptome ( Nr PRISE1 PRISE2), while only Nn PRISE) was identified, it phylogenetically closer to representatives Family 1 isoforms, designated as P5βRs. Organ-specific MeJA-elicited profiling content co-expression analysis IBG candidates, highlighted NrPRISE2 NnPRISE promising candidates orthologues, their function confirmed using vitro assays recombinant proteins, after heterologous expression proteins E. coli His-tag affinity purification. PRISE2 demonstrated activity both likely planta , which supported by 3D modeling molecular docking analysis, thus reclassification accordingly recommended. PRISE also displays ISY-like activity, its role under vivo conditions not here unambiguously confirmed. Most probably lacks substrates act upon, result loss some upstream enzymes pathway. Our ongoing work conducted towards re-establishing biosynthesis .

Language: Английский

Citations

6
A systematic UHPLC Q-ToF MS approach for the characterization of bioactive compounds from freeze-dried red goji berries (L. barbarum L.) grown in Serbia: Phenolic compounds and phenylamides DOI
Danijel D. Milinčić, Bojana Vidović, Uroš Gašić

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 140044 - 140044

Published: June 12, 2024

Language: Английский

Citations

5
Broccoli, Amaranth, and Red Beet Microgreen Juices: The Influence of Cold-Pressing on the Phytochemical Composition and the Antioxidant and Sensory Properties DOI Creative Commons

Spasoje D. Belošević,

Danijel D. Milinčić, Uroš Gašić

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 757 - 757

Published: Feb. 29, 2024

The aim of this study was to analyze in detail the phytochemical composition amaranth (AMJ), red beet (RBJ), and broccoli (BCJ) microgreens cold-pressed juices evaluate antioxidant sensory properties juices. results showed presence various phenolic compounds all samples, namely betalains microgreens, while glucosinolates were only detected microgreens. Phenolic acids derivatives dominated apigenin C-glycosides most abundant Cold-pressing into juice significantly altered profiles bioactive compounds. Various isothiocyanates BCJ, more acid aglycones their with organic (quinic malic acid) identified Microgreen exhibited good properties, especially ABTS•+ scavenging activity ferric reducing power. had mild acidity, low sugar content, acceptability quality typical flavors respective microgreen species. Cold-pressed from AMJ, RBJ, BCJ represent a rich source can be characterized as novel functional products.

Language: Английский

Citations

4
Encapsulated horseradish (Armoracia rusticana L.) root juice: Physicochemical characterization and the effects of its addition on the oxidative stability and quality of mayonnaise DOI
Jovana Marković, Ana Salević-Jelić, Danijel D. Milinčić

et al.

Journal of Food Engineering, Journal Year: 2024, Volume and Issue: 381, P. 112189 - 112189

Published: June 12, 2024

Language: Английский

Citations

4
Characterization and differentiation of beech and chestnut honeydew honeys: A comparative study DOI

Ana Barbarić,

Lara Saftić Martinović, Danijel D. Milinčić

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 477, P. 143446 - 143446

Published: Feb. 20, 2025

Language: Английский

Citations

0
Phytochemical Profile and Biological Activities of Rtanj’s Hypericum perforatum Infusion Tea and Methanolic Extracts: Insights from LC-MS/MS and HPTLC–Bioautography DOI Creative Commons
Sofija Kilibarda, Marko Jović, Danijel D. Milinčić

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(9), P. 1377 - 1377

Published: May 1, 2025

This study aimed to examine wild-growing Hypericum perforatum L. tea (Hyperici herba) collected from Rtanj Mountain (Serbia). research includes the following approaches: phytochemical and antioxidant characterization of H. infusion determine its realistic composition (What do we consume when drinking tea?), as well a detailed examination methanol(ic) extracts optimal extraction system. Due broad spectrum both polar nonpolar metabolites, 80% methanolic pure methanol were prepared for ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC Q-ToF) through untargeted metabolomics analysis. Given high diversity compounds identified, extract was selected further bioautographic characterization, including an antimicrobial activity assessment. UHPLC Q-ToF analysis identified 35 phenolics in extract, compared 25 metabolites tea. The main differences observed flavonol/flavan-3-ol aglycones, xantones, coumestans, which are more found only Notably, specific entirely absent Specifically, pseudohypericin, pseudoprotohypricin, adhyperfirin detected whereas hyperfirin present extracts. Additionally, eight furano-polycyclic polyprenylated acilphloroglucinols (FPPAPs) possible products thermal degradation and/or oxidation hypericin/hyperforin. Both exhibited excellent properties, variations depending on applied assay. High-performance thin-layer (HPTLC) also confirmed presence wide classes. Bioautography promising against Staphylococcus aureus Klebsiella pneumoniae.

Language: Английский

Citations

0
Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia DOI Creative Commons
Petar Batinić, Aleksandra Jovanović, Dejan Stojković

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 518 - 518

Published: April 17, 2024

Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended use in human therapy require specific knowledge about the chemistry and biological activities. In this study, ethanol–water extracts were prepared by maceration microwave- ultrasound-assisted extractions (MAE UAE, respectively) order to obtain bioactive molecules from Paeonia tenuifolia L., peregrina Mill., officinalis L. wild growing Serbia. Chemical characterization; polyphenol flavonoid content; antioxidant, multianti-enzymatic, antibacterial activities extracts; vitro gastrointestinal digestion (GID) hot water performed. The strongest anti-cholinesterase activity was observed PT extracts. highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), best results achieved with PO Regarding activity, strongly potent Bacillus cereus. A molecular docking simulation conducted gather insights into binding affinity interactions polyphenols other Paeonia-specific active sites tested enzymes. GID teas showed a different recovery behavior individual bioactives, an increased methyl gallate digallate decreased paeoniflorin its derivatives. (Gulenovci) (Pirot) obtained UAE M more efficient majority bioactivity assays. This study represents initial step toward possible application root pharmacy, medicine, food technologies.

Language: Английский

Citations

3
Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro DOI Creative Commons
Mateo Jakac, Irena Brčić Karačonji, Andreja Jurić

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 194 - 194

Published: March 8, 2025

Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have remarkable antioxidant activity. Since phenolics may exert dual nature (pro-oxidant antioxidant) the aim this study was investigate safety profile ethanolic extract propolis related flavonoid galangin their ability protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood were exposed 3 h three concentrations corresponding average daily dose 0.25 mL [propolis 70% ethanol (3:7, w/w)], five- ten-fold higher concentration. Cyto- genoprotective effects tested using cytokinesis-block micronucleus cytome assay. Treatment with selected exerted biocompatibility diminished level cytogenetic damage caused by irinotecan. at same concentration offered stronger protective effect than single galangin. Also, apoptosis prevailing mechanism cell death our experimental conditions. These preliminary results speak favour future investigations other available methods models.

Language: Английский

Citations

0
Patterns of Genetic Variation of Nepeta nuda L. from the Central Balkans: Understanding Drivers of Chemical Diversity DOI Creative Commons
Luka Petrović, Marijana Škorić, Branislav Šiler

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(11), P. 1483 - 1483

Published: May 27, 2024

Nepeta nuda L., a notable medicinal species in the tradition of Balkan region, is rich source bioactive iridoids and phenolics previously described as high-resolution taxonomical classifiers for genus Nepeta. However, their potential investigating intra-species differentiation here first time. The aim was to recognize sources natural chemical diversity association with genetic variability both within among N. populations Central Balkans. Chemical assessed from methanol extracts essential oils through untargeted targeted metabolomics using state-of-the-art analytical tools, covering broad spectrum compounds that represent metabolome. We found chemodiversity primarily resides nuda, similar results were obtained at DNA level microsatellite markers. low studied implies metabolomic profiles may be less influenced by geographic distance variable environmental conditions Balkans, they are under pivotal control backgrounds. Screening distribution major belonging (phenolic acids flavonoids) (both aglycones glycosylated forms), populations, able guarantee mass spectrometry-based tools selection elite representative genotypes practical importance. knowledge acquired will allow us delve deeper into molecular background diversity, which course our further work.

Language: Английский

Citations

3
Unlocking Quercetin's Neuroprotective Potential: A Focus on Bee‐Collected Pollen DOI
Aleksandar Ž. Kostić, Dılhun Keriman Arserim‐Uçar, Małgorzata Materska

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(6)

Published: Feb. 22, 2024

Abstract In the quest to evade side effects associated with synthetic drugs, mankind is continually exploring natural sources. recent decades, neurodegenerative disorders (NDDs) have surged dramatically compared other human diseases. Flavonoids, naturally occurring compounds, emerged as potential preventers of NDD development. Notably, quercetin and its derivatives demonstrated excellent antioxidant properties in fight against NDDs. Recognizing bee‐collected pollen (BP) a well‐established source derivatives, this review seeks consolidate available data on prevalence flavonoid BP, contingent upon botanical geographical origins. It aims advocate for BP superb “drugs” that could serve preventative measures Examination numerous published articles, detailing phenolic profile suggests it can be great quercetin, an average range up 1000 mg/kg. addition 24 (with rutin being most predominant) been identified. Theoretical calculations, based recommended dietary intake indicate fulfil from 0.1 over 100 % requirement, depending BP's origin bioaccessibility/bioavailability during digestion.

Language: Английский

Citations

2