Unhealthy Food Consumption Is Associated with Post-Acute Sequelae of COVID-19 in Brazilian Elderly People

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 25 - 25

Published: March 13, 2025

Background/Objectives: The factors associated with post-acute sequelae of COVID-19 (PASC) are not yet fully understood in developing countries. Our objective was to investigate the relationship between food consumption and occurrence PASC Brazilian elderly people. Methods: This cross-sectional study included 1322 people aged 60 or over, infected SARS-CoV-2 2020, living state Roraima Brazil. Using National Food Nutrition Surveillance System (SISVAN, Portuguese) tool, markers were evaluated. persistence assessed three months after infection. Poisson regression robust variance performed estimate prevalence ratio (PR) a 95% confidence interval (95% CI). Results: Fruit [PR 0.92; CI: 0.85–0.99] lower PASC, significant interaction individuals 69 years old, hospitalized, those without chronic kidney disease. In addition, sugar-sweetened beverages 1.23; 1.12–1.35], sandwich cookies, sweets, treats 1.12; CI 1.03–1.22] positively people, capital hypercholesterolemia. Conclusions: Unhealthy An improvement diet quality is necessary minimize health complications PASC.

Language: Английский

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The Role of Ultra-Processed Foods in Inflammation and Aging

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Processed foods are that undergo physical, chemical, or biological processes to enhance durability, extend shelf life, improve taste and texture, alter nutritional content, facilitate consumption. While traditional processed preserved packaged through methods such as canning salting, ultra-processed (UPFs) industrially produced formulations ready-to-eat ready-to-heat typically contain little no whole food ingredients. Recent evidence suggests the adverse health effects of UPFs may not only be due nutrients they provide but also non-nutritive components their impact on gut health. Diets rich in associated with cellular changes leading oxidative stress, which turn contributes inflammation aging processes. In this context, reducing consumption UPFs, limiting refined carbohydrates, modifying meal timing frequency recommended for improving

Language: Английский

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Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions

European Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Cognitive impairment is a prevalent complication in chronic kidney disease (CKD), ranging from mild deficits early stages to more severe conditions, such as cognitive and dementia advanced stages. CKD patients exhibit reduced performance memory, attention, language, visuospatial abilities executive functions. Contributing factors include uraemic toxins, structural brain changes, blood-brain barrier dysfunction, anaemia comorbidities like diabetes mellitus. Malnutrition, affecting nearly half of patients, exacerbates decline through inflammation, oxidative stress protein-energy wasting. Nutritional deficiencies, particularly protein, vitamin D, B vitamins, omega-3 fatty acids antioxidants, are linked impaired cognition. Emerging evidence highlights the role gut-brain axis, with gut-derived toxins microbiome alterations contributing dysfunction. Processed foods microplastics further compound risks by promoting inflammation neurotoxicity. Dialysis transplantation offer opportunities for recovery, though challenges remain, haemodialysis patients. interventions, including tailored protein intake, micronutrient supplementation dietary counselling, critical mitigating decline. Addressing comorbidities, targeted nutritional pharmacological strategies, improves outcomes. Integrating psychological social support enhances quality life, given high prevalence anxiety depression Future research should focus on personalized nutrition, gut microbiota modulation routine assessments optimise care. A holistic approach combining medical, psychosocial strategies essential improving overall health

Language: Английский

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Joint Analysis of Diet Quality, Inflammatory Potential of Diet and Ultra-Processed Food Exposure in Relation to Chronic Respiratory Diseases and Lung Cancer Mortality

Respiratory Medicine, Journal Year: 2025, Volume and Issue: 243, P. 108138 - 108138

Published: May 2, 2025

Language: Английский

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The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7827 - 7827

Published: July 17, 2024

Oxidative stress has been known about in biological sciences for several decades; however, the understanding of this concept evolved greatly since its foundation. Over past years, reactive oxygen species, once viewed as solely deleterious, have become recognized intrinsic components life. In contrast, antioxidants, initially believed to be cure-all remedies, failed prove their efficacy clinical trials. Fortunately, research on health-promoting properties antioxidants ongoing. Subsequent years showed that former assumption all acted similarly was oversimplified. Redox-active compounds differ chemical structures, electrochemical properties, mechanisms action, and bioavailability; therefore, protecting against oxidative also varies. review, we discuss changing perception sources, emphasizing everyday-life exposures, particularly those dietary origin. Finally, posit a better physicochemical outcomes is crucial fully utilize beneficial impact health.

Language: Английский

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8-OxodG: A Potential Biomarker for Chronic Oxidative Stress Induced by High-LET Radiation

DNA, Journal Year: 2024, Volume and Issue: 4(3), P. 221 - 238

Published: Aug. 1, 2024

Oxidative stress-mediated biomolecular damage is a characteristic feature of ionizing radiation (IR) injury, leading to genomic instability and chronic health implications. Specifically, dose- linear energy transfer (LET)-dependent persistent increase in oxidative DNA has been reported many tissues biofluids months after IR exposure. Contrary low-LET photon radiation, high-LET exposure known cause significantly higher accumulations damage, even at sublethal doses, compared IR. High-LET prevalent the deep space environment (i.e., beyond Earth's magnetosphere), its could potentially impair astronauts' health. Therefore, development biomarkers assess monitor levels can aid early detection risks would also allow timely intervention. Among recognized 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OxodG) emerged as promising candidate, indicative stress. It exhibit differing following equivalent doses low- This review discusses 8-OxodG potential biomarker radiation-induced stress, with special emphasis on sources, formation, repair mechanisms, methods. Furthermore, this addresses pathobiological implications association 8-OxodG. Understanding between exposure-induced systemic 8-OxodG, their provide framework for developing comprehensive monitoring system safeguard well-being astronauts during missions optimize long-term outcomes.

Language: Английский

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Food contamination and cardiovascular disease: a narrative review

Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: 19(6), P. 1693 - 1703

Published: May 14, 2024

Cardiovascular disease is a significant cause of morbidity and mortality among non-communicable diseases worldwide. Evidence shows that healthy dietary pattern positively influences many risk factors cardiometabolic health, stroke, heart disease, supported by the effectiveness diet lifestyles for prevention CVD. High quality safety foods are prerequisites to ensuring food security beneficial effects. Contaminants can be present in mainly because contamination from environmental sources (water, air, or soil pollution), artificially introduced human. Moreover, cross-contamination formation during processing, packaging, presence natural toxins, use unapproved additives adulterants. Numerous studies reported association between contaminants cardiovascular demonstrating (1) artificial sweeteners, additives, adulterants processing major adverse events (2) factors, such as heavy metals chemical products also contributors with negative impact on systems. Furthermore, oxidative stress common mechanism mediates contamination-associated CVDs substantiated showing impaired biomarkers after exposure contaminants.This narrative review summarizes data suggesting how may elicit artery injury proposing mediator damage.

Language: Английский

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The association between ultra-processed food and common pregnancy adverse outcomes: a dose-response systematic review and meta-analysis

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 15, 2024

Abstract Objectives Given the increasing incidence of negative outcomes during pregnancy, our research team conducted a dose-response systematic review and meta-analysis to investigate relationship between ultra-processed foods (UPFs) consumption common adverse pregnancy including gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth (PTB), low weight (LBW), small for age (SGA) infants. UPFs are described as formulations food substances often modified by chemical processes then assembled into ready-to-consume hyper-palatable drink products using flavors, colors, emulsifiers, other cosmetic additives. Examples include savory snacks, reconstituted meat products, frozen meals that have already been made, soft drinks. Methods A comprehensive search was performed Scopus, PubMed, Web Science databases up December 2023. We pooled relative risk (RR) 95% confidence intervals (CI) random-effects model. Results Our analysis (encompassing 54 studies with 552,686 individuals) revealed significant association intake increased risks GDM (RR = 1.19; CI: 1.10, 1.27; I 2 77.5%; p < 0.001; 44; number participants 180,824), PE 1.28; 1.03, 1.59; 80.0%; 0.025; 12; 54,955), while no relationships were found PTB, LBW SGA Importantly, 100 g increment in related 27% increase 1.07, 1.51; 81.0%; 0.007; 9; 39,812). The non-linear further indicated positive, P nonlinearity 0.034, 0.034), although such observed (P 0.696, 0.812). Conclusion In summary, both prior chronic excessive is associated an PE. However, observational studies, particularly among diverse ethnic groups precise measurement tools, imperative more understanding.

Language: Английский

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Role of Dietary Factors on DNA Methylation Levels of TNF-Alpha Gene and Proteome Profiles in Obese Men

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 877 - 877

Published: March 18, 2024

Integrated omics-based platforms from epigenomics and proteomics technologies are used to identify several important mechanisms in obesity etiology, food components, dietary intake, regulation of biological pathways, potential new intervention targets. Therefore, this study aimed analyze whether factors involved the methylation tumor necrosis factor (TNF)-α implicated differential protein expression people with normal weight obesity. Methods: The participants were classified into non-obese (N = 100) obese 133) groups. DNA levels TNF-alpha gene analyzed using pyrosequencing method LC-MS-MS, respectively. Results: Comparison between geometric means TNF-α showed lower subjects than those without (p < 0.05). There associations some metabolic syndrome components levels. Proteomic analysis signaling pathways related obesity, 95 significantly downregulated proteins 181 upregulated group compared group. Conclusion: This shows an association However, a large sample size future studies is required confirm our results.

Language: Английский

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