Impact of serum carotenoids on cardiovascular mortality risk in middle-aged and elderly adults with metabolic syndrome DOI Creative Commons
Jing Han, Ruiyun Wang, Lijuan Bai

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 13, 2024

Background Metabolic syndrome (MetS), characterized by abdominal adiposity, hypertension, hyperglycemia, and dyslipidemia, is associated with dysregulated immune function, elevated oxidative stress, chronic low-grade inflammation. Aging exacerbates insulin resistance the prevalence of MetS. Dietary antioxidants, such as carotenoids, may play a role in preventing cardiovascular disease (CVD) mortality, but evidence remains mixed, particularly among middle-aged elderly individuals Methods We analyzed data from 6,601 participants aged 40 years above MetS National Health Nutrition Examination Survey (NHANES) III (1988–1994) NHANES 2001–2006 cycles. Serum concentrations α -carotene, β lycopene, β-cryptoxanthin, combined lutein/zeaxanthin were quantified. Participants followed for median 16.8 years. Cox proportional-hazards models used to assess association between serum carotenoid CVD mortality risk, adjustment potential confounders. Results During follow-up period, 1,237 deaths identified. Analysis revealed an inverse dose–response relationship lycopene levels risk. Compared lowest quartile, multivariable-adjusted hazard ratios (95% confidence intervals) ascending quartiles 0.84 (0.71, 1.00), 0.87 (0.74, 1.03), 0.77 (0.61, 0.97), significant trend ( p = 0.039). No associations observed other carotenoids. Conclusion In this prospective cohort study 40-year-old older MetS, we

Language: Английский

Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe DOI Creative Commons
Xinjian Song, Xumei Wang, Yan Wang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(45), P. 18132 - 18140

Published: Oct. 30, 2024

Maintaining tissue homeostasis necessitates the coordinated efforts of various cell types to regulate inflammation. Endoplasmic reticulum (ER) stress, a hallmark inflammation, exacerbates pathology in human diseases. Glutathione (GSH), pivotal regulator cellular redox balance, controls disulfide bond formation ER, thereby shielding cells from oxidative stress. In this study, we developed two-photon fluorescent probe, ER-GSH, with specific ER targeting and demonstrated its high sensitivity rapid response GSH. Experiments conducted on BV2 mice model neuroinflammation induced by scrap leather revealed that inflammatory reactions led stress substantial reduction GSH levels. Notably, anti-inflammatory drug NS-398 effectively inhibited inflammation maintaining These findings underscore potential therapeutic significance modulating levels alleviate impact neuroinflammation.

Language: Английский

Citations

5
Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways DOI
Mega O. Oyovwi,

Ejime A. Chijiokwu,

Benneth Ben‐Azu

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Lipid Oxidation in Meat: From Fundamental Mechanisms to Latest Control Solutions DOI
Wei Luo, Jingnan Zhang, Haizhou Wu

et al.

Advances in food and nutrition research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Impact of serum carotenoids on cardiovascular mortality risk in middle-aged and elderly adults with metabolic syndrome DOI Creative Commons
Jing Han, Ruiyun Wang, Lijuan Bai

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 13, 2024

Background Metabolic syndrome (MetS), characterized by abdominal adiposity, hypertension, hyperglycemia, and dyslipidemia, is associated with dysregulated immune function, elevated oxidative stress, chronic low-grade inflammation. Aging exacerbates insulin resistance the prevalence of MetS. Dietary antioxidants, such as carotenoids, may play a role in preventing cardiovascular disease (CVD) mortality, but evidence remains mixed, particularly among middle-aged elderly individuals Methods We analyzed data from 6,601 participants aged 40 years above MetS National Health Nutrition Examination Survey (NHANES) III (1988–1994) NHANES 2001–2006 cycles. Serum concentrations α -carotene, β lycopene, β-cryptoxanthin, combined lutein/zeaxanthin were quantified. Participants followed for median 16.8 years. Cox proportional-hazards models used to assess association between serum carotenoid CVD mortality risk, adjustment potential confounders. Results During follow-up period, 1,237 deaths identified. Analysis revealed an inverse dose–response relationship lycopene levels risk. Compared lowest quartile, multivariable-adjusted hazard ratios (95% confidence intervals) ascending quartiles 0.84 (0.71, 1.00), 0.87 (0.74, 1.03), 0.77 (0.61, 0.97), significant trend ( p = 0.039). No associations observed other carotenoids. Conclusion In this prospective cohort study 40-year-old older MetS, we

Language: Английский

Citations

1