Foods,
Journal Year:
2024,
Volume and Issue:
13(24), P. 4176 - 4176
Published: Dec. 23, 2024
Type
2
diabetes
mellitus
(T2DM)
and
cancer
are
significant
contributors
to
morbidity
mortality
worldwide.
Recent
studies
have
increasingly
highlighted
the
potential
of
phytochemicals
found
in
plants
plant-based
foods
for
preventing
treating
these
chronic
diseases.
Mexico’s
agrobiodiversity
provides
a
valuable
resource
phytochemistry.
This
review
presents
an
examination
essential
within
Mexican
that
shown
promising
anti-cancer
anti-diabetic
properties,
including
their
roles
as
antioxidants,
insulin
sensitizers,
enzyme
inhibitors.
Notable
compounds
identified
include
flavonoids
(such
quercetin
catechins),
phenolic
acids
(chlorogenic,
gallic,
caffeic
acids),
methylxanthines
(like
theobromine),
xanthones
mangiferin),
capsaicinoids
(capsaicin),
organosulfur
alliin),
various
lipids
(avocatins).
Although
promise
laboratory
animal
studies,
there
is
scarcity
clinical
trial
data
involving
humans,
underscoring
important
area
future
research.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 506 - 506
Published: Feb. 10, 2024
The
healthy
properties
of
pomegranate
fruit,
a
highly
consumed
food,
have
been
known
for
long
time.
However,
the
supply
chain
is
still
rather
inefficient,
with
non-edible
fraction,
whose
weight
roughly
half
total
and
endowed
plenty
valuable
bioactive
compounds,
either
disposed
or
underutilized.
A
novel
extract
obtained
from
byproducts
(called
PPE),
using
hydrodynamic
cavitation,
green,
efficient,
scalable
technique,
was
investigated
its
cardiovascular
effects
in
vivo.
PPE
showed
efficacy
an
acute
phenylephrine
(PE)-induced
hypertensive
rat
model,
similar
to
whole
fruit
(PFE)
same
extractive
along
good
intestinal
bioaccessibility
after
oral
administration.
Finally,
when
chronically
administered
6
weeks
spontaneously
rats,
shown
significantly
contain
increase
systolic
blood
pressure,
comparable
reference
drug
Captopril,
at
dose
remarkably
lower
than
reported
effective
ellagic
acid.
fraction
also
anti-inflammation
anti-fibrotic
effects.
findings
this
study,
extraction
could
contribute
enhancing
value
chain,
relieve
related
environmental
burden,
potentially
improve
public
health.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(3)
Published: Jan. 1, 2025
Abstract
The
side
effects
of
the
cancer
treatment
medications
that
have
sparked
renewed
interest
in
herbal
formulation
research.
Due
to
its
high
phytochemical
content,
Punica
granatum
L.
(different
parts
pomegranate),
a
basic
traditional
medicine
source,
is
an
excellent
option
for
anticancer
In
this
study,
activity
(Hicaz
variety)
peel
extract
on
Hep3B
cell
line
was
determined
by
MTT
test.
results
showed
P.
cytotoxic
effect
(cancer)
but
no
AML12
(healthy).
To
explain
effect,
main
bioactive
components
peel,
which
are
ellagic
acid,
abscisic
ethyl
gallate,
phlorizin,
gallic
and
myricetin,
were
performed
docking
study
with
EGFR‐TK
(PDB
ID:
1M17).
poses
all
selected
compounds
bind
same
site
as
inhibitor
erlotinib,
while
acid
(−8.8
kcal/mol),
myricetin
(−8.9
phlorizin
(−8.7
kcal/mol)
lower
binding
energy.
Also,
drug
similarity,
physicochemical,
ADMET
properties
these
phenolic
evaluated.
All
indicated
could
be
potential
therapeutic
candidate
against
liver
cancer.
Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi,
Journal Year:
2025,
Volume and Issue:
16(1), P. 75 - 81
Published: April 24, 2025
Objective:
Epicatechin
(EC)
is
one
of
the
major
components
green
tea
catechins.
This
study
investigated
effect
amount
epicatechin
obtained
by
brewing
under
optimal
conditions
against
oxidative
stress
induced
hydrogen
peroxide
(H2O2).
Materials
and
Methods:
In
peripheral
blood
mononuclear
cells
(PBMCs),
determined
optimum
was
applied
250
µM
H2O2
cell
viability
MTT
test,
total
antioxidant
status
(TAS)
oxidant
(TOS)
were
biochemical
analysis,
apoptosis-related
Bax,
Bcl2,
p53
expression
analysis
qRT-PCR
method.
Results:
The
significantly
higher
in
H2O2+EC
group
than
(p
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1102 - 1102
Published: Feb. 29, 2024
Certain
food
by-products,
including
not-good-for-sale
apples
and
pomegranate
peels,
are
rich
in
bioactive
molecules
that
can
be
collected
reused
formulations.
Their
extracts,
pectin
antioxidant
compounds,
were
obtained
using
hydrodynamic
cavitation
(HC),
a
green,
efficient,
scalable
extraction
technique.
The
extracts
chemically
physically
characterized
used
gluten-free
vegan
cookie
formulations
to
replace
part
of
the
flour
sugar
study
whether
they
mimic
role
these
ingredients.
amount
+
removed
replaced
with
was
5%
10%
total.
Physical
(dimensions,
color,
hardness,
moisture
content,
water
activity),
chemical
(total
phenolic
DPPH
radical-scavenging
sensory
characteristics
samples
studied.
Cookies
supplemented
apple
extract
endowed
similar
or
better
compared
control
cookies:
high
spread
ratio,
characteristics.
In
contrast,
peel
enriched
cookies
but
significantly
changed
their
physical
characteristics:
hardness
value,
different
bitter
astringent
taste.
HC
emerged
as
feasible
technique
enable
biofortification
consumer
products
at
real
scale
from
agri-food
by-products.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(10), P. 1796 - 1796
Published: Sept. 23, 2023
Pomegranate
(Punica
granatum
L.)
is
well
known
for
its
high
content
of
bioactives,
including
polyphenols,
flavonoids,
and
tannins,
which
have
been
shown
to
exhibit
a
wide
range
biological
activities,
such
as
antioxidant,
antimicrobial,
anticancer
effects.
It
worth
noting
that
the
majority
these
molecules
are
found
in
peels,
usually
disposed
after
processing,
causing
significant
amount
waste,
amounting
more
than
3.6
million
t/y.
This
work
investigates
microwave-assisted
extraction
(MAE)
water
recovery
antioxidants
from
pomegranate
peels
(PP),
optimisation
temperature
times.
The
total
phenolic,
anthocyanin,
flavonoid,
tannin
contents
recovered
extracts
were
determined,
their
antioxidant
be
356.35
mgGAE/gExtr,
303.97
µgCy3G/gExtr,
37.28
mgQE/gExtr,
56.48
5.72
mmolTE/gExtr,
respectively
(according
adopted
reference).
All
results
compared
with
those
obtained
using
conventional
protocol.
In
addition,
potential
recycling
by
means
downstream
nanofiltration
optimised
MAE
was
investigated,
leading
overall
reuse
approx.
75%.
Power
consumption
(20.92
W/mgGAE)
common
green
metrics,
Reaction
Mass
Efficiency
(RME),
E-Factor,
Process
Intensiti/efficiency
(PMI,
PME),
considered
evaluating
proposed
PP
valorisation
strategy.
Finally,
activities
main
products
assessed.
antimicrobial
properties
against
three
Gram-positive
Gram-negative
bacteria
antiproliferative
activity
towards
human
cancer
cells
tested.
S.
aureus
most
susceptible
extracts.
tested
displayed
HeLa
when
higher
concentrations
tested,
D-PP/NF
(obtained
dried
sequential
nanofiltration)
being
effective.
result
also
confirmed
via
clonogenic
analysis,
generally
indicated
possible
anti-cancer
peel
this
approach.
Dose-Response,
Journal Year:
2024,
Volume and Issue:
22(2)
Published: April 1, 2024
This
research
investigated
the
anticancer
properties
of
punicalagin,
a
prominent
bioactive
polyphenol
extracted
from
Punica
granatum
L,
in
human
gastric
cancer
cell
lines.
Normal
and
cells
were
exposed
to
different
doses
punicalagin
for
various
durations.
Punicalagin
exhibited
cytotoxic
effects
on
dose-
time-dependent
fashion,
while
sparing
normal
epithelial
cells.
It
is
noteworthy
that
among
3
cells,
HGC-27
more
resistant
than
23,132/87
AGS
Furthermore,
triggered
apoptosis
evidenced
by
rise
both
early
late
apoptotic
percentages.
Western
blot
analysis
further
revealed
elevated
levels
activated
caspase-3.
Conversely,
curtailed
invasion
reduced
expression
MMP-2,
MMP-9,
Snail,
Slug.
From
mechanistic
standpoint,
blotting
indicated
might
inhibit
Erk
NF-κB
pathways,
leading
induction
inhibition
These
results
indicate
promotes
inhibits
activating
caspase-3
suppressing
Slug
through
pathways.
Natural Product Sciences,
Journal Year:
2024,
Volume and Issue:
30(2), P. 80 - 92
Published: June 30, 2024
The
study
investigated
the
potential
antiurolithiatic
effects
of
an
aqueous
extract
from
dried
Punica
granatum
leaves.
extract,
obtained
using
Soxhlet
extraction
method,
yielded
less
than
22%.
Acute
toxicity
studies
established
LDSUB50/SUB
values
and
safety
indicating
no
harmful
even
at
concentrations
up
to
2000
mg/kg
body
weight.
A
starting
therapeutic
dose
1/10SUPth/SUP
(200
mg)
was
chosen,
setting
a
dosage
range
100
400
weight
for
subsequent
experiments.
Male
rats
were
selected
induce
urolithiasis
due
similarity
their
urinary
system
humans.
induced
in
by
administering
ethylene
glycol,
effectively
replicating
stone
formation
observed
Microscopic
examination
highlighted
extract's
impede
crystal
growth,
critical
factor
urolithiasis.
Urine
volume
emphasized
kidney
function
disruption
calculi-induced
group,
while
groups
treated
with
Cystone
test
phytochemical
showed
increased
urine
output,
potentially
aiding
flushing
out
calculi.
further
explored
changes,
pH,
routine
analysis,
formation,
calcium
oxalate
excretion,
serum
biochemical
analysis.
Treatment
specific
doses
prevented
increase
markers
associated
damage,
suggesting
protective
effect
against
nephritic
damage.
Histopathological
revealed
mitigate
depositions
renal
tissue
abnormalities.
Additionally,
exhibited
nephroprotective
gentamicin-induced
nephrotoxicity,
underlining
its
broader
on
health.
