Critical Reviews in Microbiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 31
Published: April 11, 2024
Periodontitis
is
an
immuno-inflammatory
disease
of
the
soft
tissues
surrounding
teeth.
linked
to
many
communicable
and
non-communicable
diseases
such
as
diabetes,
cardiovascular
disease,
rheumatoid
arthritis,
cancers.
The
oral-systemic
link
between
periodontal
systemic
attributed
spread
inflammation,
microbial
products
microbes
distant
organ
systems.
Oral
bacteria
reach
gut
via
swallowed
saliva,
whereby
they
induce
dysbiosis
gastrointestinal
dysfunctions.
Some
pathogens
like
Porphyromonas.
gingivalis,
Klebsiella,
Helicobacter.
Pylori,
Streptococcus,
Veillonella,
Parvimonas
micra,
Fusobacterium
nucleatum,
Peptostreptococcus,
Haemophilus,
Aggregatibacter
actinomycetomcommitans
Streptococcus
mutans
can
withstand
unfavorable
acidic,
survive
in
result
dysbiosis.
Gut
increases
dysplastic
changes
that
lead
dysfunction.
Various
studies
have
oral
bacteria,
oral-gut
axis
various
GIT
disorders
inflammatory
bowel
liver
diseases,
hepatocellular
pancreatic
ductal
carcinoma,
ulcerative
colitis,
Crohn's
disease.
Although
correlation
periodontitis
well
established,
intricate
molecular
mechanisms
by
which
microflora
these
not
been
discussed
extensively.
This
review
comprehensively
discusses
unique
immunological
Exploration of Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
The
gut
microbiota,
a
complex
ecosystem
of
microorganisms,
plays
an
essential
role
in
maintaining
immune
and
metabolic
homeostasis.
Disruption
this
microbial
balance,
known
as
dysbiosis,
has
been
increasingly
implicated
the
pathogenesis
chronic
inflammatory
conditions,
including
cardiovascular,
gastrointestinal,
autoimmune
diseases,
well
disorders
such
diabetes
obesity.
A
crucial
mechanism
through
which
microbiota
exerts
its
effects
on
host
physiology
is
via
production
bioactive
metabolites.
These
metabolites,
short-chain
fatty
acids,
bile
tryptophan
derivatives,
are
key
modulating
responses
regulating
functions.
Dysbiosis
disrupts
function
these
thereby
contributing
to
dysregulation,
inflammation,
disease
progression.
This
review
examines
microbiota-derived
metabolites
with
focus
their
immunomodulatory
effects.
deeper
understanding
mechanisms
may
open
way
for
novel
therapeutic
strategies
aimed
at
restoring
homeostasis
mitigating
global
burden
diseases.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
This
article
provides
an
overview
of
the
advancements
in
application
fecal
microbiota
transplantation
(FMT)
treating
diseases
related
to
intestinal
dysbiosis.
FMT
involves
transfer
healthy
donor
into
patient's
body,
aiming
restore
balance
and
thereby
treat
a
variety
such
as
recurrent
Clostridioides
difficile
infection
(rCDI),
inflammatory
bowel
disease
(IBD),
constipation,
short
syndrome
(SBS),
irritable
(IBS).
While
has
shown
high
efficacy
treatment
rCDI,
further
research
is
needed
for
its
other
chronic
conditions.
elaborates
on
mechanisms
dysbiosis,
well
discusses
key
factors
influencing
effectiveness
FMT,
including
selection,
recipient
characteristics,
protocols,
methods
assessing
microbiota.
Additionally,
it
emphasizes
successful
FMT.
Future
should
focus
optimizing
process
ensure
long‐term
safety
explore
potential
broader
range
medical
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 5, 2024
The
source
of
protein
in
a
persons
diet
affects
their
total
life
expectancy.
However,
the
mechanisms
by
which
dietary
sources
differentially
impact
human
health
and
expectancy
are
poorly
understood.
Dietary
choices
have
major
impacts
on
composition
function
intestinal
microbiota
that
ultimately
mediate
host
health.
This
raises
possibility
outcomes
based
might
be
driven
interactions
between
gut
microbiota.
In
this
study,
we
determine
effects
seven
different
mice.
We
apply
an
integrated
metagenomics-metaproteomics
approach
to
simultaneously
investigate
these
microbiotas
function.
abundances
measured
metaproteomics
can
provide
microbial
species
abundances,
evidence
for
phenotype
members
molecular
level
because
proteins
allow
us
infer
metabolic
physiological
processes
used
community.
showed
significantly
altered
overall
Different
led
changes
abundance
amino
acid
degrading
involved
degradation
glycosylations
protein.
particular,
brown
rice
egg
white
increased
enzymes
bacteria
usually
associated
with
mucus
barrier.
These
results
show
change
metabolism,
could
implications
context
mediated
diseases.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(6), P. 633 - 633
Published: May 29, 2024
Ulcerative
colitis
(UC)
is
an
autoimmune
disease
in
which
the
immune
system
attacks
colon,
leading
to
ulcer
development,
loss
of
colon
function,
and
bloody
diarrhea.
The
human
gut
ecosystem
consists
almost
2000
different
species
bacteria,
forming
a
bioreactor
fueled
by
dietary
micronutrients
produce
bioreactive
compounds,
are
absorbed
our
body
signal
distant
organs.
Studies
have
shown
that
Western
diet,
with
fewer
short-chain
fatty
acids
(SCFAs),
can
alter
microbiome
composition
cause
host's
epigenetic
reprogramming.
Additionally,
overproduction
H
ACS Synthetic Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Bacteroides
thetaiotaomicron
is
a
common
microorganism
in
the
human
gut
that
has
been
linked
to
health
benefits.
Furthermore,
it
an
emerging
synthetic
biology
chassis
with
potential
be
modified
into
diagnostic
or
therapeutic
engineered
probiotics.
However,
absence
of
biological
components
limits
its
further
applications.
In
this
study,
we
developed
antiterminator
microbial
whole-cell
biosensor
(MWCB)
based
on
B.
thetaiotaomicron.
The
antiterminator-based
element
allows
detect
colitis
mice
by
responding
nitrate
and
nitrite
inflammatory
environment.
particular,
nitrate/nitrite-inducible
promoter
was
obtained
combining
constitutive
inducible
terminator.
Subsequently,
RBS
were
replaced
optimize
sensitive
specific
response
nitrate/nitrite.
A
preliminary
vitro
assessment
conducted
ascertain
functionality
biosensor.
Its
vivo
sensing
ability
evaluated
chemically
induced
mouse
model
ulcerative
(UC).
results
demonstrated
MWCB
exhibited
robust
colitis,
notable
positive
correlation
between
intensity
level
inflammation.
This
novel
may
provide
new
avenue
for
development
unconventional
chassis,
like
It
will
also
facilitate
probiotics
thetaiotaomicron,
thereby
providing
patients
wider
range
medical
treatment
options.
