Experimental Neurology, Journal Year: 2024, Volume and Issue: 383, P. 115037 - 115037
Published: Oct. 30, 2024
Language: Английский
Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Depression is a common mental disorder characterized by high prevalence and significant adverse effects, making the searching for effective interventions an urgent priority. In recent years, physical activity (PA) has increasingly been recognized as standard adjunctive treatment disorders owing to its low cost, easy application, efficiency. Epidemiological data shows positive preventive therapeutic effects of PA on illnesses such depression. This article systematically describes prophylactic depression biological basis. A comprehensive literature analysis reveals that significantly improves depressive symptoms upregulating expression “exerkines” irisin, adiponectin, BDNF positively impacting neuropsychiatric conditions. particular, lactate could also play critical role in ameliorating due findings about protein lactylation novel post-transcriptional modification. The suggests terms brain structure, may improve hippocampal volume, basal ganglia (neostriatum, caudate-crustal nucleus) PFC density patients with MDD. summary, this study elucidates multifaceted potential mechanisms particular emphasis roles various exerkines. Future research further investigate different types, intensities, durations depression, well how better integrate into existing strategies achieve optimal outcomes health interventions.
Language: Английский
Citations
1
Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: June 7, 2024
Chronic low back pain patients often experience recurrent episodes due to various peripheral and central factors, leading physical mental impairments, affecting their daily life work, increasing the healthcare burden. With continuous advancement of neuropathological research, changes in brain structure function chronic have been revealed. Neuroplasticity is an important mechanism self-regulation plays a key role neural injury repair. Targeting neuroplasticity regulating nervous system improve functional impairments has become research focus rehabilitation medicine. Recent studies shown that exercise can beneficial effects on body, such as improving cognition, combating depression, enhancing athletic performance. Exercise-induced may be potential through which affects brain. This article systematically introduces theory exercise-induced neuroplasticity, explores with pain, further looks forward new directions targeted neuroplasticity-based treatment for pain.
Language: Английский
Citations
5
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Abstract Mitochondria, known as the powerhouse of cell, are essential for cellular energy production. Dysfunction in mitochondrial function can significantly affect various organs. Transplanting healthy mitochondria enhance bioenergetics diseased cells and treat conditions, yet limits transplantation still unknown. Our study reveals that source transplanted is not restricted by species, recipient show no significant immune response to from different lineages. We also found metabolic compatibility between exogenous crucial, transplanting species endow with distinct characteristics combat diseases. Furthermore, our data indicate there competition among varying functions, more powerful yielding better therapeutic effects. Notably, we have an upper limit bio-enhancement provided mitochondria. research proposes a feasible path human through transplantation—adaptive bio-enhancement. Mitochondrial highly clinically valuable technique. I further expanded variety sources demonstrated potential adaptively biological functions.
Language: Английский
Citations
1
International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 2035 - 2050
Published: Sept. 1, 2024
While the benefits of exercises for chronic obstructive pulmonary disease (COPD) are well-established, relative effectiveness different exercise types stable COPD remains unclear. This network meta-analysis aims to investigate comparative effects aerobic (AE), resistance training (RT), endurance (ET), and high-intensity interval (HIIT) in COPD.
Language: Английский
Citations
1
Experimental Neurology, Journal Year: 2024, Volume and Issue: 383, P. 115037 - 115037
Published: Oct. 30, 2024
Language: Английский
Citations
1